Protein Alignment by and TNS1

DIOPT Version :10

• Sequence 1: NP_649901.1
• Gene: by / 41144
• FlyBaseID: FBgn0000244
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: XP_047301592.1
• Gene: TNS1 / 7145
• HGNCID: 11973
• Length: 2111
• Species: Homo sapiens
• Alignment Length: 780
• Identity: 238/780 - (30%)
• Similarity: 331/780 - (42%)
• Gaps: 230/780 - (29%)

  Fly    70 ENSLPFSYGIAKTST-----PLRK--------TPTPTRVDS-FLDFDFGPTNTNVNSNSSSNNGG 120
            ::|.|.|:....|..     |||.        :|:|....| .|..|    :|:|.|..|..:..
Human  1416 QDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILSAD----STSVGSFPSGESSD 1476

  Fly   121 TGDMIKPPTRLTSPLL---VRKTLGNAVSPTSSTNTNTIANTYHYTSSSATPTPVRDNFEQLLRE 182
            .|     |...|.|||   .|.  |:...|:.|...|       |.|||..||
Human  1477 QG-----PRTPTQPLLESGFRS--GSLGQPSPSAQRN-------YQSSSPLPT------------ 1515

  Fly   183 RREKVYNEYRNLD------RESSGERAR---------VAPAPPQRQYY-------PSDGYGIGLK 225
                |.:.|.:.|      ..|...:||         ..|..||.::.       ||.|:|....
Human  1516 ----VGSSYSSPDYSLQHFSSSPESQARAQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAI 1576

  Fly   226 NDS-----------------NGTLYR----KSPSSNGKSTKYNYDFEFNLNLDDVRPEPTPYTTR 269
            |.|                 .||.:.    .||.|:..:|                 ..:|...|
Human  1577 NPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATT-----------------PGSPSLCR 1624

  Fly   270 NIHFEDLRLDQDVPDGVVNRRTMERNYHTINSLETTHKRQQL--EPLEQLGAVYGQNHMEETLTR 332
            :            |.||.....:.      |.:.||.....|  .|    ||..|
Human  1625 H------------PAGVYQVSGLH------NKVATTPGSPSLGRHP----GAHQG---------- 1657

  Fly   333 TRRDLSASTSTSKSTSP-LPAI-----GVPAIAPASPI---------YATSTKRVSNPNTNGQQQ 382
               :|::...::...|| .|::     |..::.|.||.         |:|...|  .|..:  :|
Human  1658 ---NLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDR--RPTLS--RQ 1715

  Fly   383 MTPSPTSRPETPAFPVTP------RTPFGASSSSSASL---APTTQLPPESIYQTGPRRGVPPAL 438
            .:.|....|.||:|||:|      .:|..:.|..||:.   :||..||.:.....|.|.|..|..
Human  1716 SSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNY 1780

  Fly   439 QPLEVSADS---------------------------------------VQFARSSSQFWYKPNLT 464
            ..:.....|                                       |:|.:.:|::||||.::
Human  1781 ATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEIS 1845

  Fly   465 REDAIALLASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPG----------SQELVRHFLIEPTKG 519
            ||.|||||...:||.|::|||.:::.:|||.::||.|||.          :.|||||||||....
Human  1846 REQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPR 1910

  Fly   520 GVHLKGCDDEPVFTSLSALVFEHSISQLALPCLLRLPDRDIVPPVR-ATTPAQQ--HLLAHGAAT 581
            ||.||||.:||.|.||||||::|||..|||||.|.:|:||.....: ::.||..  .||..|||.
Human  1911 GVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAAC 1975

  Fly   582 NVLWLYSCDTESLTGNEAIRKAIRQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKFFRKHYKAD 646
            |||::.|.|.|||||.:||.||..:.....|.|..|.||||||:||||||||.||.|||:||..:
Human  1976 NVLFVNSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLN 2040

  Fly   647 VISHCAIDPENRMW-TSEGESDKKTIFAFVARRSHSSTDNQCHVFCDLSVSQPAAAIVSFANRTL 710
            .::.|.:||:.|.| .:||.:..| :|.||||:..|:|||.||:|.:|..:|||:|||:|.::.:
Human  2041 TVTFCDLDPQERKWMKTEGGAPAK-LFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVM 2104

  Fly   711  710
            Human  2105  2104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_649901.1	SH2_Tensin_like	454..559	CDD:198181	60/114 (53%)
		PTB_tensin	578..711	CDD:269924	69/134 (51%)
TNS1	XP_047301592.1	C1	37..123	CDD:412127
		PTP_tensin-1	245..403	CDD:350408
		PTEN_C2	410..536	CDD:463081
		PHA03247	<858..1273	CDD:223021
		PHA03247	<1367..1766	CDD:223021	96/439 (22%)
		SH2_Tensin_like	1835..1950	CDD:198181	60/114 (53%)
		PTB_tensin	1972..2105	CDD:269924	69/134 (51%)