DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and tns1a

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_009300586.1	Gene:	tns1a / 565181	ZFINID:	ZDB-GENE-120215-32	Length:	1688	Species:	Danio rerio

Alignment Length:	786	Identity:	218/786 - (27%)
Similarity:	324/786 - (41%)	Gaps:	221/786 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GIGNGNGYGIPYHARENSLPFSYGIAKTSTPLRKTPTPTRVDSFLDFDFGPTNTNVNSNSSSNNG 119
            ||.....:...:|   .|..||...::|.||....||..|           ..|:.:...||.:.
Zfish   988 GISKSMSFQSEHH---RSYSFSGSHSRTVTPDEAMPTVRR-----------RTTSESQYLSSQHD 1038

  Fly   120 GTGDMIKPPTRLTSPLLVRKTLGNAVSPTSSTNTNTIANTYHYTSSSATPTPVRDNFEQL----- 179
            ....:::.|                :.|.||...|||...........:....|:.||::
Zfish  1039 SAAHVVRSP----------------LKPVSSEFANTITMNPGGQPKEKSVHSYREAFEEMESAPF 1087

  Fly   180 -------------------LR-ERREKVYNEYRNLDRESSGER---------------------- 202
                               || :...:...:..:.|.:||.|.
Zfish  1088 SSAHDNAGLSGQATLSAAGLRAQNPAEALVQQNSSDSDSSDEMEEPHGFVGTGIREGGFISPLHH 1152

  Fly   203 ----ARVAPAPPQRQYYP--------SDGYGIGLKNDSNGTLYRKSPSSNGKSTKYNYDFEFNLN 255
                |...|.||...:.|        |||:|       |...:...||...::..:...|.:
Zfish  1153 PYSPASERPVPPAHTFSPPQPVNNTSSDGFG-------NQRAFPSFPSEPIRAPLFLDTFSY--- 1207

  Fly   256 LDDVRPEPTPYTTRNIHFEDLRLDQDVPDGVVN--RRTMERNYHTINSLETTHKRQQLEPLEQLG 318
               :.|:........||        .|| |..|  .||:..|.....:|:           .:||
Zfish  1208 ---LNPDEATVNIMGIH--------HVP-GSPNTLHRTVATNTPPSPALQ-----------RRLG 1249

  Fly   319 A----VYGQNHMEETLTRTRRDLSASTSTSKSTSPLPAIG----------------VPAIAPASP 363
            .    .:|           ||..:|::.:..:|...|.:|                .||...:||
Zfish  1250 GPSSPAFG-----------RRITTANSGSEPTTPNSPLLGRSGKFIPPSPVLDRHPSPAPVASSP 1303

  Fly   364 IYATSTKRVSNPNTNGQQQMTPSPTSRPE----TPAFPV---------TPRTPFGASSSSSASLA 415
            .:....:..:.|:.....|...|.||..:    ||.||:         .|......||..::...
Zfish  1304 DHKVLPRGQATPDERHGAQSRQSITSTVQPGHATPTFPIEQSSSPSLFLPLDIRAGSSMENSESG 1368

  Fly   416 PT----TQLPPE-----SIYQTGPRRGVPPALQPLEVSADSVQFARSSSQFWYKPNLTREDAIAL 471
            |.    ||:||:     |||..      ||.::      .:::|.:.:|::||||.:|||.||.:
Zfish  1369 PADCGPTQVPPQGPAITSIYDG------PPDIR------INIKFVQDTSKYWYKPEITREQAICI 1421

  Fly   472 LASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPGSQ----------ELVRHFLIEPTKGGVHLKGC 526
            |...:||.|::|||.:::.:|||.::|:.|||..|          |||||||||.:..||.||||
Zfish  1422 LKDREPGAFVIRDSNSFRGAYGLAMKVASPPPTVQQNKKVGDITNELVRHFLIETSAKGVRLKGC 1486

  Fly   527 DDEPVFTSLSALVFEHSISQLALPCLLRLPDRD-------IVPPVRATTPAQQHLLAHGA----- 579
            .:||.|..|||||::|:|:.|||||.|.:|.||       :..|..:|    ..||..||
Zfish  1487 PNEPYFGCLSALVYQHAITPLALPCKLMIPTRDPNEEALELATPTSST----MDLLKQGAGPPKP 1547

  Fly   580 -----ATNVLWLYSCDTESLTGNEAIRKAIRQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKFF 639
                 |.|||::.|.|.|||||.:|:.|||.:....:..|..|.|.||||:||||||||.||.||
Zfish  1548 TEDFYACNVLYINSVDMESLTGPQAVAKAITETLAAKSTPTATIVQFKVSTQGITLTDNQRKVFF 1612

  Fly   640 RKHYKADVISHCAIDPENRMWTSEGESDKKTIFAFVARRSHSSTDNQCHVFCDLSVSQPAAAIVS 704
            |:||..::|::|.:||:.|.| ::.|.....:|.||||:..|:|||..|:|.:|.....|:||||
Zfish  1613 RRHYPINLITYCNMDPQERKW-NKAEGGVAKLFGFVARKQGSTTDNVSHLFAELEPDNSASAIVS 1676

  Fly   705 FANRTL 710
            |.::.:
Zfish  1677 FVSKLM 1682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	57/114 (50%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	64/143 (45%)
tns1a	XP_009300586.1	C1	<55..88	CDD:197519
		PTPc_motif	188..>257	CDD:214649
		PTEN_C2	297..424	CDD:287393
		SH2_Tensin_like	1404..1519	CDD:198181	57/114 (50%)
		PTB_tensin	1553..1683	CDD:269924	62/131 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5004
eggNOG	1	0.900	-	-		E2759_KOG1930
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24267
orthoMCL	1	0.900	-	-		OOG6_103416
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.770