DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and tns1b

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_021334702.1	Gene:	tns1b / 555362	ZFINID:	ZDB-GENE-030131-6933	Length:	1829	Species:	Danio rerio

Alignment Length:	870	Identity:	239/870 - (27%)
Similarity:	330/870 - (37%)	Gaps:	248/870 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RENSLPFSYGIAKTSTPLRKTPTPTR---VDSFLDFDFGPTNTNVNSNSSSNNGGTGDMIKPPTR 130
            |..||.|| |:........:...|.|   :...|..|..||.              |..::.|.|
Zfish   986 RRRSLSFS-GLPSGEMSPDEAAVPGRCRTLSEGLSQDESPTR--------------GSSVRSPIR 1035

  Fly   131 LTSPLLVRKTL-----------------------GNAVSPTSSTNTNTIANTYHYTSSSATP--- 169
            ..||.|.....                       |..|||........:..|..:..|..||
Zfish  1036 CISPELANTIALNPGGRPKERHMHSYREAFEEMDGGPVSPPPIVGGEVLPQTPAFPVSPQTPYFN 1100

  Fly   170 ----------TPV-------RDNFEQLLRERREKVYNEYRNLDRESSGERARVAPAPP------- 210
                      ||:       .:..|.||.:...:..:|........|..:|...||.|
Zfish  1101 MCRSPPGLAKTPLSFLGLKPHNPAEILLNQTGSESEDEEEPRSYVESVAKAAAVPASPTYDSDSL 1165

  Fly   211 QRQYYPSDGYGIGLKNDS--------NGTLYRKSPSSNGKSTKYNYDFEFNLNLDDVRPEPTPYT 267
            .|...||..|...|.:.|        ..||.......|..|......|.|..:....:|.|.||.
Zfish  1166 ARPAGPSHAYNAPLSSSSPIQNPDPVESTLADSGVGMNSLSQAAVDIFHFQPSEIPYQPPPPPYP 1230

  Fly   268 TRNI-----------------------------------------HFEDLRLDQDVP-------- 283
            |..:                                         :|:....:||.|
Zfish  1231 TSMLGSYISPSPAEAMQNNTTTIQPLSGSPGTRHHTILSDMASVPNFQHRLANQDGPILGRQQAP 1295

  Fly   284 ----------DGVVNRRTM-----------ERNYHTINSLETTH--KRQQLEPLEQLGAVYGQ-- 323
                      ..|..|.||           .|.|.....::::.  .||.:....|...|..:
Zfish  1296 ANGHVPGIAGSPVQGRHTMVSQGTQSSPILSRQYPVTQGIQSSPILSRQPMGQAVQSSPVLNRQA 1360

  Fly   324 -----NHMEETLTRTRR---------DLSASTSTSKSTSPLPAIG-VPAIAPASPI--------- 364
                 |.....|:|.:.         .||..:|.|..:...|.:| .|::...||.
Zfish  1361 SLNQANQSSPVLSRQQSITLPNQGSPVLSRQSSLSHPSQGSPVLGRHPSLTQGSPSLDRHPMYSG 1425

  Fly   365 YATSTKRVSNPNTNG--QQQMTPSPTSRPETPAFPVTPRTPFGASSSSSASLAPTTQLPPESIYQ 427
            |.|..:|      :|  .:|.:.|....|.||:|||:|......:.....|.|...|||.:....
Zfish  1426 YTTPEER------HGALSRQSSSSGYQPPSTPSFPVSPAGYIEGAGFRQGSPAFQPQLPEKRRMS 1484

  Fly   428 TGPRR--------------------GVPPALQPLEVSAD---------------SVQFARSSSQF 457
            :..|.                    |..|::.......|               :|:|.:.:|:|
Zfish  1485 SSDRTNGGLSYGTLNGKMSSPVSSGGSTPSVHFFHTLPDFSKLNMCDGSPETRMNVKFVQDTSKF 1549

  Fly   458 WYKPNLTREDAIALLASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPGSQ----------ELVRHF 512
            ||||:::|:.||.:|....||.|::|||.:::.:|||.::|:.|||.:|          ||||||
Zfish  1550 WYKPDISRDQAINMLKDQDPGAFVIRDSHSFRGAYGLAMKVASPPPTTQPTKKAGDVTNELVRHF 1614

  Fly   513 LIEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQLALPCLLRLPDRD-------IVPPVRATTPA 570
            |||.:..||.||||.:||.|..|||||::|||:.|||||.|.:|.||       |..|   |.||
Zfish  1615 LIETSPKGVRLKGCPNEPYFGCLSALVYQHSITPLALPCKLVIPTRDPLEESPEIATP---TNPA 1676

  Fly   571 Q--------QHLLAHGAATNVLWLYSCDTESLTGNEAIRKAIRQMYGQQPLPQPTEVHFKVSSQG 627
            .        |...|.|.|.|||::.|.|.|||||.:||.|||.:.....|.|..|.||||||:||
Zfish  1677 ADMLKQGAGQKSSADGHACNVLYINSVDMESLTGPQAIAKAISETMNASPAPSATIVHFKVSAQG 1741

  Fly   628 ITLTDNTRKKFFRKHYKADVISHCAIDPENRMWTS-EGESDKKTIFAFVARRSHSSTDNQCHVFC 691
            ||||||.||.|||:||....::.|.|||:.|.|.. ||.:.|  .|.||||:..|:|||..|:|.
Zfish  1742 ITLTDNQRKLFFRRHYPIGTVTFCDIDPQERKWNKPEGGTAK--FFGFVARKQGSTTDNVSHLFA 1804

  Fly   692 DLSVSQPAAAIVSFANRTLPTEKLR 716
            ::...|||.|||:|.::.:.:.:.|
Zfish  1805 EMDPDQPATAIVNFVSKVMISSQKR 1829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	57/114 (50%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	68/133 (51%)
tns1b	XP_021334702.1	C1	45..91	CDD:237996
		PTPc_motif	208..323	CDD:214649
		PTEN_C2	310..436	CDD:313607
		Atrophin-1	<806..1199	CDD:331285	45/227 (20%)
		Herpes_ICP4_C	1140..>1534	CDD:332854	70/399 (18%)
		SH2_Tensin_like	1546..1661	CDD:198181	57/114 (50%)
		PTB_tensin	1692..1824	CDD:269924	68/133 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5004
eggNOG	1	0.900	-	-		E2759_KOG1930
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24267
orthoMCL	1	0.900	-	-		OOG6_103416
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.800