DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and PVRAP

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_729124.1	Gene:	PVRAP / 38677	FlyBaseID:	FBgn0052406	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	116/516 - (22%)
Similarity:	181/516 - (35%)	Gaps:	153/516 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GIAKTSTPLRKTPTPTRVDSFLDFDFGPTNTNVNSNSSSNNGGTGDMIKPPTRLTSPLLVRKTLG 142
            |.|.||..:......|...|    :..||..|.||||:||:...               :.:.|.
  Fly    36 GTAATSVAMSNRNGSTSSSS----NSSPTADNSNSNSNSNSNAN---------------INRNLN 81

  Fly   143 NAVSPTSSTNTNTIANTYHYTSSSATPTPVRDNFEQLLRERREKVYNEY-----RNLDRESSGER 202
            .  :|.|::|||  :|:|                           :|.:     .||....:|..
  Fly    82 Q--NPNSNSNTN--SNSY---------------------------FNRFDNRIAANLAAVLTGAG 115

  Fly   203 ARVAPAPPQRQYYPSDGYGIGLKNDS-----NGTLYRK-------SPSSNGKSTKYNYDFEFNLN 255
            ||.      |....|:.:..|:.|.:     ..|:.||       ||:|.|:..........|||
  Fly   116 ARF------RSSSCSNRHPAGVANPAVLRSPLATISRKTSLATPPSPASLGRRRPLQLFTHANLN 174

  Fly   256 L-DDVRPEPTPYTTRNIHFEDL----RLDQDVPDGVVNRRTM------ERNYHTINSLETTHKRQ 309
            . |:.:...||.:..:....:|    ||....|  :|.|.||      |.:...:..:.......
  Fly   175 CNDNEKVAQTPSSDEDNSPTELNSCKRLADKPP--LVKRLTMGLLRQNEESRPLVGDMTPLSAPL 237

  Fly   310 QLEPLEQLGAVYGQNHMEETLTRTRRDLSASTSTSKSTSPLPAIGVPAIAPASPIYATSTKRVSN 374
            .::|      ||...::.|.   :..|.....|..:|.:.:|.:                   .|
  Fly   238 DIQP------VYSNGYINED---SYIDSKFGDSCRQSLTAIPML-------------------DN 274

  Fly   375 PNTNGQQQM---------TPSPTSRPETPAFPVTPRTPFGASSSSSASLAPTTQLPPESIYQTGP 430
            .|.|...:.         |.|..|.|:  .|....|...||.....:|||       .:....|.
  Fly   275 VNLNDNNEFNLKKRYLRETSSANSSPK--IFANRLRMNQGAVGQRCSSLA-------NAFGNVGS 330

  Fly   431 RRGVPPALQPLEVSADSVQFARSSSQFWYKPNLTREDAIALLASAQPGTFLVRDSTTYKDSYGLV 495
            ..      :.||:          ....||:..::|:.|:.:|.|..||.||||.|::....|.|.
  Fly   331 DE------EDLEL----------KDACWYQAGISRDIAVEVLQSKSPGAFLVRKSSSKPGCYALT 379

  Fly   496 VRVSQPPPGSQELVRHFLIEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQLALPCLLRLP 556
            :||.. |||.:  :.:::|..:..|..:||...|  |:||.||:..||:....||..|.:|
  Fly   380 LRVPS-PPGPK--IANYIILRSPRGYKIKGFRKE--FSSLKALITHHSVMPELLPVPLAMP 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	36/103 (35%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924
PVRAP	NP_729124.1	SH2	342..435	CDD:301589	35/97 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45734
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940