DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and Tns3

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_011242029.1	Gene:	Tns3 / 319939	MGIID:	2443012	Length:	1553	Species:	Mus musculus

Alignment Length:	657	Identity:	208/657 - (31%)
Similarity:	308/657 - (46%)	Gaps:	131/657 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 FGPTNTNVNSNSSSNNGGTGDMIKPPTRLTSPLLVRKTLGNAVSPTSSTNTNTIANTYHYTSSSA 167
            |.|....::|.:|.:.|      :.|.  ..|.::..|:|.:.||.....|...|:      ..|
Mouse   972 FSPPEPQLSSPASLHKG------REPR--GCPEIISHTVGMSESPVGPKPTMLRAD------MPA 1022

  Fly   168 TPTPVRDNFEQLLRERREKVYNEYRNLDRESSGERARVAPAPPQRQYYPSDGYG----IGLKNDS 228
            ||     ||:|        |:.....:.....|:| |.:|...:||:..|....    :|..:.|
Mouse  1023 TP-----NFQQ--------VFASSCTVSSNGPGQR-RESPPSAERQWVESSPKSTLTLLGNSHPS 1073

  Fly   229 NGTLYRKSPSSNGKSTKYNYDFEFNLNLDDVRPEPTPYTTRNIHFEDLRLDQDVPDGVVNRRTME 293
            ...|......|:||.:.....|:            :.....:.|..:|.:.:  |.|.:.....:
Mouse  1074 ESPLGTHEFCSSGKDSPGLPCFQ------------SSELQASFHSHELSMSE--PQGALPPAGSQ 1124

  Fly   294 R--NYHTINSLETTHKRQQLEPLEQLGAVYGQNHMEETLTRTRRDLSASTSTSKSTSPLPAIGVP 356
            .  .::|:.:..:.     |.|.|..|.:...:|                    .|||.|  |.|
Mouse  1125 TFLGFNTVTTATSV-----LPPGEDAGTLLVNSH--------------------GTSPAP--GTP 1162

  Fly   357 AIAPASP-------IYATSTKRVSNPNTNGQQQMTPSPTSRPETPAFPVTPRTPFGASSSSSASL 414
            .:...:.       .:.|.:...|:.::.|.|...   .|.|..|..|...|...|..|..|.|
Mouse  1163 LLTTGAADNGFLPHNFLTVSPGASSHHSPGLQNQN---VSLPGQPPLPEKKRASEGDRSLGSVS- 1223

  Fly   415 APTTQLPPESIYQTGPRRG----------VPPALQPLEVSA---DS-------VQFARSSSQFWY 459
                   |.|...:.|..|          :|...:|.||::   ||       |:|.:.:|:|||
Mouse  1224 -------PSSSGFSSPHSGSTMSIPFPNVLPDFCKPSEVASPLPDSPNDKLVIVKFVQDTSKFWY 1281

  Fly   460 KPNLTREDAIALLASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPG-----------SQELVRHFL 513
            |.:::||.|||:|....||:|:||||.:::.:|||.::|:.|||.           |.|||||||
Mouse  1282 KADISREQAIAMLKDKAPGSFIVRDSHSFRGAYGLAMKVATPPPSVLHLNKKAGDLSNELVRHFL 1346

  Fly   514 IEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQLALPCLLRLPDRDIVPPVRATTP-----AQQH 573
            ||.|..||.||||.:||.|.||:|||.:|||:.|||||.|.:|:||.:..:...:|     :...
Mouse  1347 IECTPKGVRLKGCSNEPYFGSLTALVCQHSITPLALPCKLLIPERDPLEEIAENSPQTAANSAAE 1411

  Fly   574 LLAHGAATNVLWLYSCDTESLTGNEAIRKAIRQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKF 638
            ||..|||.||.:|.|.:.|||||::|::||:.....|:|.|..|.||||||:||||||||.||.|
Mouse  1412 LLKQGAACNVWYLNSVEMESLTGHQAVQKALSMTLVQEPPPVSTVVHFKVSAQGITLTDNQRKLF 1476

  Fly   639 FRKHYKADVISHCAIDPENRMWTSEGESDKKTIFAFVARRSHSSTDNQCHVFCDLSVSQPAAAIV 703
            ||:||....:..||:||::|.|..:|.|.|  :|.||||:..|:|||.||:|.:....|||:|||
Mouse  1477 FRRHYPVSSVIFCALDPQDRKWIKDGPSSK--VFGFVARKQGSATDNVCHLFAEHDPEQPASAIV 1539

  Fly   704 SFANRTL 710
            :|.::.:
Mouse  1540 NFVSKVM 1546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	60/115 (52%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	68/133 (51%)
Tns3	XP_011242029.1	C1	35..81	CDD:237996
		PTP_tensin-3	121..279	CDD:350409
		PTEN_C2	286..412	CDD:371036
		PHA03307	645..>1077	CDD:223039	29/132 (22%)
		PHA03247	<907..1186	CDD:223021	51/282 (18%)
		SH2_Tensin_like	1276..1392	CDD:198181	60/115 (52%)
		PTB_tensin	1416..1547	CDD:269924	68/133 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4813
eggNOG	1	0.900	-	-		E2759_KOG1930
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3453
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44309
orthoMCL	1	0.900	-	-		OOG6_103416
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.850