Protein Alignment by and Tns4

DIOPT Version :10

• Sequence 1: NP_649901.1
• Gene: by / 41144
• FlyBaseID: FBgn0000244
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_001020052.1
• Gene: Tns4 / 303517
• RGDID: 1310402
• Length: 718
• Species: Rattus norvegicus
• Alignment Length: 701
• Identity: 196/701 - (27%)
• Similarity: 288/701 - (41%)
• Gaps: 178/701 - (25%)

  Fly    71 NSLPFSYGIAKTSTPLRKTPTPTRVDS---------------FLDFDFGPTNTNVNSNSS---SN 117
            ::|...| |..|||..|...:|.|..|               ||..|. |..|..:||.|   |.
  Rat   140 DALDIKY-IEVTSTRSRCLDSPQRCSSPCVTPPFGSPRSGGLFLSRDI-PRETRSSSNESLIFSG 202

  Fly   118 NGGTGDMIKPPTRLTSPLLVRKTLGNAVSPTSSTNTNTIANTYHYTSSSATPTPVRDNFEQLLRE 182
            |.|.|         :||                          |..||.:...|.|::
  Rat   203 NQGRG---------SSP--------------------------HTPSSLSNSIPCRES------- 225

  Fly   183 RREKVYNEYRNLDRESSGERARVAP--APPQRQYYPSDGYGIGLKNDSNGTLYRKSPSSNGKSTK 245
                               ||..:|  .||        |:..||:....|:  |.|..|....:.
  Rat   226 -------------------RASGSPLATPP--------GWEKGLRAPQWGS--RVSTLSASPVSD 261

  Fly   246 YNYDFEFNLNLDDVRPEPTPYTTRNIHFEDLRLDQDVPDGVVNRRTMERNYHTINSLETTHKRQQ 310
            .:|.|..|.:|........|.::|:
  Rat   262 ISYVFGSNQSLPHSSLSSYPPSSRS---------------------------------------- 286

  Fly   311 LEPLEQLGAVYGQNHMEETLTRTRRDLSASTSTSKSTSPLPAIGVPAIAPASPIYATSTKRVSNP 375
                  ||:....:....:|.|..:.:.:|.:...| :|:..:|.|...|::|:...........
  Rat   287 ------LGSPASSSSSLHSLDRGSQCVRSSDAQVPS-NPIVGMGQPQAVPSTPVAKEQASSCPPS 344

  Fly   376 NTNGQQQM-------TPSPTSRP--ETPAF-------PVTPRTPFGASSSSSASLAPTTQLPPES 424
            .||....:       .|.|.|.|  :||.:       ..:|.....|:.|.|.:|.......|..
  Rat   345 VTNSMADIPIVLINGNPEPQSPPAQQTPRYQDSVQSRATSPSHLCQATKSHSKTLPDVPLTSPSH 409

  Fly   425 IYQTGPRRG-----VPPALQPLEVSAD---SVQFARSSSQFWYKPNLTREDAIALLASAQPGTFL 481
            :.|......     ||....|...:.|   :::|...:|::|.||::|||.||.||.:.:||||:
  Rat   410 LCQATKSHSKTLPDVPLTASPESPAKDMQPTMKFVMDTSKYWLKPSITREQAINLLRTEKPGTFV 474

  Fly   482 VRDSTTYKDSYGLVVRVSQPP------PG--SQELVRHFLIEPTKGGVHLKGCDDEPVFTSLSAL 538
            :|||::|:.|:||.::|.:.|      ||  |.:.:||||:|.:..||||||.|:||.|.||||.
  Rat   475 IRDSSSYRGSFGLALKVQETPASAPNRPGEDSTDFIRHFLVESSAKGVHLKGADEEPYFGSLSAF 539

  Fly   539 VFEHSISQLALPCLLRLPDRDI---VPPVRATTPAQQHLLAHGAATNVLWLYSCDTESLTGNEAI 600
            |.:|||..|||||.|.:|.:::   .|...:.|..|...|...|..:.|:|.|...|:|:|..|:
  Rat   540 VCQHSIMALALPCKLTIPQKELGGAEPASDSPTHGQTSCLKISAGCHTLYLTSVSVETLSGALAV 604

  Fly   601 RKAIRQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKFFRKHYKADVISHCAIDPENRMWTSEGE 665
            :|||..|..:..||.||.|||||:.|||||||..||.|||:||....:..|.:|||.|.|....:
  Rat   605 QKAISVMLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLIALRFCGMDPEQRKWQKYCK 669

  Fly   666 SDKKTIFAFVARRSHSSTDNQCHVFCDLSVSQPAAAIVSFANRTL-PTEKL 715
            ..:  ||.|||:......:|.||:|.:...:|||:.::|.....| .||::
  Rat   670 PSR--IFGFVAKSQTEPQENACHLFAEYDAAQPASQVISLVTALLKDTERV 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_649901.1	SH2_Tensin_like	454..559	CDD:198181	57/112 (51%)
		PTB_tensin	578..711	CDD:269924	55/133 (41%)
Tns4	NP_001020052.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..244		23/124 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..437		32/211 (15%)
		SH2	447..560	CDD:472789	57/112 (51%)
		PTB_tensin	583..712	CDD:269924	54/130 (42%)