Protein Alignment by and TNS2

DIOPT Version :9

• Sequence 1: NP_001163569.1
• Gene: by / 41144
• FlyBaseID: FBgn0000244
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: XP_006719365.1
• Gene: TNS2 / 23371
• HGNCID: 19737
• Length: 1428
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 197/647 - (30%)
• Similarity: 288/647 - (44%)
• Gaps: 162/647 - (25%)

  Fly   210 PQRQY----YPS-DGYGIGLKNDSNGTLYRKSP---SSNGKSTKYNYDFEFNLNLDDVRPEPTPY 266
            |:.:|    ||: ..|..|....|....|.:.|   .|.|:...|......:.....:.|...||
Human   793 PEGRYGHPGYPALVTYSYGGAVPSYCPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISPGSPPY 857

  Fly   267 TTRNIHFEDLRLDQDVP--DGVVNRRTMERNYHTINSLETTHKRQQLEPLEQLGAVYGQNHMEET 329
            .      :..:|..::|  :| .:|..:..:..:...|.:.   :.|||:.......|.:    |
Human   858 P------QSRKLSYEIPTEEG-GDRYPLPGHLASAGPLASA---ESLEPVSWREGPSGHS----T 908

  Fly   330 LTRTRRD--LSASTSTSKSTSPL-----------------------------PAIGVPAI----- 358
            |.|:.||  .|||:..|..::||                             |...:|.:
Human   909 LPRSPRDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGT 973

  Fly   359 -----------------APASPIYATST------KRVSNPNTNGQQQMTPSPTSRP--------- 391
                             :|.||.:..|:      :|....:::|....:|.||:.|
Human   974 GKAPELPSGSGPEPLAPSPVSPTFPPSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQG 1038

  Fly   392 ---------ETPAFPVTPRTPFGASSSSSASLAPTTQLPPESIYQT------------------- 428
                     .:|..||..:.|:..:|......:||...|..:.|.|
Human  1039 PRGPPDSPDGSPLTPVPSQMPWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQ 1103

  Fly   429 -----------GPRRGV------PPALQ---------PLEVSADSVQFARSSSQFWYKPNLTRED 467
                       .|.||:      .|.|.         |.:.|..:|:|.:.:|:|||||:|:|:.
Human  1104 QPGPWGPEQASSPARGISHHVTFAPLLSDNVPQTPEPPTQESQSNVKFVQDTSKFWYKPHLSRDQ 1168

  Fly   468 AIALLASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPGSQ--------ELVRHFLIEPTKGGVHLK 524
            |||||....||.||:|||.:::.:|||.::|:.|||.:|        :||||||||....||.:|
Human  1169 AIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLIETGPKGVKIK 1233

  Fly   525 GCDDEPVFTSLSALVFEHSISQLALPCLLRLPDRDIV-----PPVRATTPAQQHLLAHGAATNVL 584
            ||..||.|.||||||.:||||.::|||.||:|.:|.:     .||.........||..|||.:||
Human  1234 GCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETPEAPVPTNMSTAADLLRQGAACSVL 1298

  Fly   585 WLYSCDTESLTGNEAIRKAIRQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKFFRKHYKADVIS 649
            :|.|.:||||||.:|:.:|........|.|.|..||||||:||||||||.||.|||:||..:.|:
Human  1299 YLTSVETESLTGPQAVARASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFRRHYPVNSIT 1363

  Fly   650 HCAIDPENRMWTS-EGESDKKTIFAFVARRSHSSTDNQCHVFCDLSVSQPAAAIVSFANRTL 710
            ..:.||::|.||: :|.:.|  ||.|||::..|..:|.||:|.:|...|||.|||:|..:.|
Human  1364 FSSTDPQDRRWTNPDGTTSK--IFGFVAKKPGSPWENVCHLFAELDPDQPAGAIVTFITKVL 1423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	60/112 (54%)
		PTB_tensin	578..711	CDD:269924	66/134 (49%)
TNS2	XP_006719365.1	C1	42..89	CDD:237996
		PTPc_motif	199..319	CDD:214649
		PTEN_C2	307..434	CDD:287393
		SH2_Tensin_like	1155..1268	CDD:198181	60/112 (54%)
		PTB_tensin	1292..1424	CDD:269924	66/134 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4840
eggNOG	1	0.900	-	-		E2759_KOG1930
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42255
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45734
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.900