DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and Tns1

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_006495930.2	Gene:	Tns1 / 21961	MGIID:	104552	Length:	1922	Species:	Mus musculus

Alignment Length:	748	Identity:	233/748 - (31%)
Similarity:	334/748 - (44%)	Gaps:	188/748 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SYGIAKTSTPLRK--------TPTPTRVDS-FLDFDFGPTNTNVNSNSSSNNGGTGDMIKPPTRL 131
            :||   ..||||.        :|:|....| .|..|    :|:|.|..|..:...|     |...
Mouse  1243 AYG---HETPLRNGTPGGSFVSPSPLSTSSPILSAD----STSVGSFPSVVSSDQG-----PRTP 1295

  Fly   132 TSPLL---VRK-TLGNAVSPTSSTNTNTIANTYHYTSSSATPTPVRDNFEQLLRERREKVYN--E 190
            ..|:|   :|. :||.. ||.:.:          |.|||  |.||..:           .||  :
Mouse  1296 FQPMLDSSIRSGSLGQP-SPAALS----------YQSSS--PVPVGGS-----------SYNSPD 1336

  Fly   191 YR----NLDRESSGE------RARVAPAPPQRQYY-------PSDGYGIGLKNDSNGTLYRK-SP 237
            |.    :...||.|:      ...:.|..||.::.       ||.|:|   :...|.|:... ||
Mouse  1337 YSLQPFSSSPESQGQPQYSAASVHMVPGSPQARHRTVGTNTPPSPGFG---RRAVNPTMAAPGSP 1398

  Fly   238 SSNGKSTKYNYDFEFNLNLDDVRPEPTPYTTRNIHFEDLRLDQDVPDGVVNRRTMERNYHTINSL 302
            |.:.:.........|:.|:....|.....|..:            |.  :.|..:  ..|.:..|
Mouse  1399 SLSHRQVMGPSGPGFHGNVVSGHPASAATTPGS------------PS--LGRHPV--GSHQVPGL 1447

  Fly   303 ETTHKRQQLEPLEQLGAVYGQNHMEETLTRTRRDLSASTSTSKSTSP-LPAI-----GVPAIAPA 361
            .::.......|  .||...|.:         :.:|::|..::...|| .|::     |..::.|.
Mouse  1448 HSSVVTTPGSP--SLGRHPGAH---------QGNLASSLHSNAVISPGSPSLGRHLGGSGSVVPG 1501

  Fly   362 SPI---------YATSTKRVSNPNTNGQQQMTPSPTSRPETPAFPVTP------RTPFGASSSSS 411
            ||.         |:|...|  .|..:  :|.:.|....|.||:|||:|      .:|..:.|..|
Mouse  1502 SPSLDRHAAYGGYSTPEDR--RPTLS--RQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDS 1562

  Fly   412 ASL---APTTQLPPESIYQTGPRRGVPPALQPLEVSADS-------------------------- 447
            |:.   :||..||.:.....|.|.|..|....:.....|
Mouse  1563 AAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSSPVANGMASGSSTVSFSHTLPDFSKY 1627

  Fly   448 ------------VQFARSSSQFWYKPNLTREDAIALLASAQPGTFLVRDSTTYKDSYGLVVRVSQ 500
                        |:|.:.:|::||||.::||.|||||...:||.|::|||.:::.:|||.::||.
Mouse  1628 SMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSS 1692

  Fly   501 PPPG----------SQELVRHFLIEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQLALPCLLRL 555
            |||.          :.|||||||||....||.||||.:||.|.||||||::||:..|||||.|.:
Mouse  1693 PPPTITQQGKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSVIPLALPCKLVI 1757

  Fly   556 PDRDIVP-------PVRATTPAQQHLLAHGAATNVLWLYSCDTESLTGNEAIRKAIRQMYGQQPL 613
            |.||...       |..:||    .||..|||.|||::.|.|.|||||.:||.||..:.....|.
Mouse  1758 PSRDPTDESKDSSGPANSTT----DLLKQGAACNVLFVNSVDMESLTGPQAISKATSETLAADPT 1818

  Fly   614 PQPTEVHFKVSSQGITLTDNTRKKFFRKHYKADVISHCAIDPENRMW-TSEGESDKKTIFAFVAR 677
            |..|.||||||:||||||||.||.|||:||..:.::.|.:||:.|.| .:||.:..| :|.||||
Mouse  1819 PAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAK-LFGFVAR 1882

  Fly   678 RSHSSTDNQCHVFCDLSVSQPAAAIVSFANRTL 710
            :..|:|||.||:|.:|..:|||:|||:|.::.:
Mouse  1883 KQGSTTDNACHLFAELDPNQPASAIVNFVSKVM 1915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	59/114 (52%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	69/134 (51%)
Tns1	XP_006495930.2	C1	<79..112	CDD:381770
		PTP_DSP_cys	189..347	CDD:391942
		PTEN_C2	354..480	CDD:371036
		PHA03247	<737..1233	CDD:223021
		PHA03247	<1073..1649	CDD:223021	99/475 (21%)
		SH2_Tensin_like	1646..1761	CDD:198181	59/114 (52%)
		PTB_tensin	1783..1916	CDD:269924	69/134 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4813
eggNOG	1	0.900	-	-		E2759_KOG1930
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44309
orthoMCL	1	0.900	-	-		OOG6_103416
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.800