DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and tns2

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_002936689.3	Gene:	tns2 / 100486792	XenbaseID:	XB-GENE-988669	Length:	1850	Species:	Xenopus tropicalis

Alignment Length:	821	Identity:	228/821 - (27%)
Similarity:	340/821 - (41%)	Gaps:	239/821 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EESAAAADHKYQYQ--YTAANNNNNYYKNYNVNGNGQ-----ANGNGNLSGIGNGNGIGNGNGYG 63
            :.|.|:..|....|  :||..::    .:..:||:.|     ..|:|.|..: :..|....|
Frog  1147 QTSPASPTHSPSSQTGHTAQLSS----PSVQLNGSSQHMSLAVQGHGQLHSL-DERGQAQDN--- 1203

  Fly    64 IPYHARENSLPFSYGIAKTSTPLRKTPTPTRVDSFLDFDFGPTNTNVNSNSSSNNGGTGDMIKPP 128
            :|.|    ||.|                             |||..||:.||.:...    |...
Frog  1204 VPTH----SLTF-----------------------------PTNNPVNTKSSPDQSD----ISNH 1231

  Fly   129 TRLTSPLLVRKTLGNAVSPTSSTNTNTIA----NTY----HYTSSSATPTPVRDNFEQLLRERRE 185
            |:.||     |.:.|...|:.....|.:|    |:|    ::|..|...|||...|.....:|
Frog  1232 TQNTS-----KEVHNTALPSEPQTGNCVARQITNSYPHSPNHTHISEDQTPVTTAFALTETDR-- 1289

  Fly   186 KVYNEYRNLDRESSGERARVAPAPPQRQYYPSDGYGIGLKNDSNGTLYRKSPSSNGKSTKYNYDF 250
                                    ||::...|                ..|.|.|..|
Frog  1290 ------------------------PQQKMVQS----------------HSSVSVNNSS------- 1307

  Fly   251 EFNLNLDDVRPEPTPYTTRNIHFEDLRLDQDVPDGVVNRRTMERNYHTINSLETTHKRQQLEPLE 315
                    |:|..|.:|...:...|..::..:|...::....:.:...::|  |.|       .:
Frog  1308 --------VKPYSTVHTQSQLVQTDNSIESQIPPVQLHHPVPKASQAQLHS--TVH-------TQ 1355

  Fly   316 QLGAVYGQN-----------HMEETLTRTRRDLSAS--------------TSTSKSTSPLPAIGV 355
            ....|.||:           |...|:...|..|.|:              ..||.|.|.:....:
Frog  1356 LYRTVGGQSPSVPTQKPVPTHPNSTVVTERPGLPATHVNAPPCANEANTLLPTSSSQSHVTKFVL 1420

  Fly   356 PAIAPASPIYATSTKRVSNPNTN--------GQQQMTPSPT----SRPETPAFPVTPRTPFGASS 408
            |..:.|...:.|....:|:|:..        .|....|..|    .|..|.:.||:|..|.|..:
Frog  1421 PVTSEAKRSHTTFGPAISSPSGTTAFGSGYCSQSFSVPKHTVLLQKRSVTISLPVSPVNPQGKEA 1485

  Fly   409 SSSASLAP----TTQLPPE---------SIYQTGPRRGVPPALQPLEV------SADSVQ----- 449
            .:|...:|    :..|||.         :.|.:.|   .||::||..:      .||..:
Frog  1486 PTSPPKSPMGSQSDLLPPSPTPSFPIRTAYYSSSP---CPPSIQPPRLPEKNHSPADGAKVDPNG 1547

  Fly   450 -----------------------FARSSSQFWYKPNLTREDAIALLASAQPGTFLVRDSTTYKDS 491
                                   |.:.||:|||||.::||.|||:|..|:||:||:|||.:::.:
Frog  1548 LSECNKGHSSPVDTQQDVPVTGNFVQDSSKFWYKPTISREQAIAILRGAEPGSFLIRDSNSFRGA 1612

  Fly   492 YGLVVRVSQPPP----------GSQELVRHFLIEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQ 546
            |||.::|:.|||          .:::||||||||....||.:||...||.|.||||||.:||::.
Frog  1613 YGLALKVASPPPNVAAQPYKGDSTEQLVRHFLIETGPKGVKIKGSPIEPHFGSLSALVSQHSVTP 1677

  Fly   547 LALPCLLRLPDRDIVP-------PVRATTPAQQHLLAHGAATNVLWLYSCDTESLTGNEAIRKAI 604
            |:|||.|::|.||::.       |...:|.|.  ||..|||.:||:|.|.|||||||.:||.:|.
Frog  1678 LSLPCRLQIPSRDLIEQSSEVMVPTNMSTAAD--LLRQGAACSVLYLGSVDTESLTGPQAISRAS 1740

  Fly   605 RQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKFFRKHYKADVISHCAIDPENRMWTSEGESDKK 669
            ..:. ..|....|.||||||.|||||||:.||.|||:||....::.|..||::|.||:...:..|
Frog  1741 NAIL-TPPRSSATTVHFKVSDQGITLTDSQRKLFFRRHYPVSSVTFCNSDPQDRRWTNPDRTTSK 1804

  Fly   670 TIFAFVARRSHSSTDNQCHVFCDLSVSQPAAAIVSFANRTL 710
             :|.||||::.::.:|.||:|.:|...|||:|||:|..:.:
Frog  1805 -VFGFVARKAGTAAENVCHLFAELDPEQPASAIVNFITKVM 1844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	57/114 (50%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	63/133 (47%)
tns2	XP_002936689.3	C1_TNS2	30..82	CDD:410437
		PTP_tensin-2	130..288	CDD:350410
		PTEN_C2	300..425	CDD:402161
		PHA03247	<859..1170	CDD:223021	6/26 (23%)
		Herpes_BLLF1	<1040..1527	CDD:282904	96/498 (19%)
		SH2_Tensin_like	1575..1690	CDD:198181	57/114 (50%)
		PTB_tensin	1714..1845	CDD:269924	63/133 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I5060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49485
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940