DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment by and tns1

DIOPT Version :9

Sequence 1:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_031749629.1	Gene:	tns1 / 100216306	XenbaseID:	XB-GENE-957068	Length:	1866	Species:	Xenopus tropicalis

Alignment Length:	734	Identity:	218/734 - (29%)
Similarity:	313/734 - (42%)	Gaps:	187/734 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PFSY--GIAKTS-----TPLRKTPTPTRVDSFLDFDFGPTNTNVNSNSSSNNGGTGDMIKPPTRL 131
            |.||  .:|:|:     .|    |:||          ||...:|  :|...|||.      |...
Frog  1226 PRSYVESVARTAAAGGVAP----PSPT----------GPQAYSV--DSLMRNGGY------PNVF 1268

  Fly   132 TSPLLVRKTLGNAVSPTSST----NTNTIANTYHYTSSSA-TPTPVRDNFEQLLRERREKVYNEY 191
            |||           ||.|::    :|:....:|....|.| .|||.:.:.
Frog  1269 TSP-----------SPISTSSPIHSTDGSLRSYPSVESGARVPTPTQPSV--------------- 1307

  Fly   192 RNLDRESSGERARVAPAPPQRQYYPSDGYGIGLKNDSNGTLYRKSPSSNGKSTKYNYDFEFNLNL 256
                 :||.....::...||..|          :|.|....|..:|:|       :||
Frog  1308 -----DSSFRSTSLSQPSPQSSY----------QNASPMVPYAGTPAS-------SYD------- 1343

  Fly   257 DDVRPEPTPYTTRNIHFEDLRLDQDVPDGVVNR------RTMERNYHTINSLETTHKRQQLEP-- 313
                  ..||:..:...:...|.....:.|:..      :.:.|...|.........|:.:.|
Frog  1344 ------GYPYSPSSALTQTDGLSGPQMNAVIGHMVHGSPKAVHRTVGTNTPPSPGFGRRMVTPNM 1402

  Fly   314 -----LEQLGAVYGQNHMEETLTRTRRDLSASTSTSKSTSPLPAIGVPAIAPASP------IYAT 367
                 ...:|......||...:|.....|....:.....:|        :.|.||      :|..
Frog  1403 APPPGSPSMGRHPMATHMAAPVTVGSPSLPLHQALMTGNAP--------VTPGSPGLERHVMYGY 1459

  Fly   368 STKRVSNPNTNGQQQMTPSPTSRPETPAFPVTPRTPFGASSSSSASL--------APTTQ--LPP 422
            |......|..:  :|.:.|....|.||:|||:|....|.||.||:|.        :|.:|  ||.
Frog  1460 SPADDKRPTLS--RQSSASGYQAPPTPSFPVSPAYYHGMSSPSSSSPDSTLYRQGSPISQPSLPE 1522

  Fly   423 ESIYQTGPRRGVPPALQPLEVSADS---------------------------------------V 448
            :....:|.|....|....|.....|                                       |
Frog  1523 KRRMSSGDRSNSLPNYSTLNGKTSSPMSSGMSSPSGGSTMAFTHTLPDFSKFSMPDSSPETRANV 1587

  Fly   449 QFARSSSQFWYKPNLTREDAIALLASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPG--------- 504
            :|.:.:|::||||:::|:.||:||....||.|::|||.:::.:|||.::|:.|||.
Frog  1588 KFVQDTSKYWYKPDISRDQAISLLKDKDPGAFIIRDSHSFRGAYGLAMKVATPPPNAGQPSKKGD 1652

  Fly   505 -SQELVRHFLIEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQLALPCLLRLPDRDIVPPVRAT- 567
             :.|||||||||.:..||.||||.:||.|..|||||::|||:.|||||.|.:|.||.....:.|
Frog  1653 VTNELVRHFLIETSPRGVKLKGCQNEPYFGCLSALVYQHSITPLALPCKLVIPCRDPSDETKETA 1717

  Fly   568 TPAQ--QHLLAHGAATNVLWLYSCDTESLTGNEAIRKAIRQMYGQQPLPQPTEVHFKVSSQGITL 630
            .||.  ..||..|||.|||::.|.|.|||||.:||.|.|.:.....|.|....||||||:|||||
Frog  1718 VPANSASDLLKQGAACNVLFINSIDMESLTGPQAIAKTIAESLAADPPPAAAIVHFKVSAQGITL 1782

  Fly   631 TDNTRKKFFRKHYKADVISHCAIDPENRMWTSEGESDKKTIFAFVARRSHSSTDNQCHVFCDLSV 695
            |||.||.|||:||....::.|.:||:.|.| .:.:..:..:|.||||:..|:|||.||:|.:|..
Frog  1783 TDNQRKLFFRRHYPLSSVTFCDLDPQERKW-MKADGTQAKLFGFVARKQGSTTDNMCHLFAELDP 1846

  Fly   696 SQPAAAIVSFANRTLPTEK 714
            :|||.|||:|.:|.:..:|
Frog  1847 NQPATAIVNFVSRVIGLQK 1865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	56/114 (49%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	66/132 (50%)
tns1	XP_031749629.1	PHA03247	<904..1435	CDD:223021	55/291 (19%)
		SH2_Tensin_like	1593..1708	CDD:198181	56/114 (49%)
		PTB_tensin	1730..1861	CDD:269924	66/131 (50%)
		C1	42..98	CDD:412127
		PTP_tensin-1	147..305	CDD:350408
		PTEN_C2	312..438	CDD:402161
		PRK03427	811..>941	CDD:235124
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I5060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49485
Panther	1	1.100	-	-	O	PTHR45734
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.100