DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JHDM2 and AT4G00990

DIOPT Version :9

Sequence 1:	NP_001287255.1	Gene:	JHDM2 / 41143	FlyBaseID:	FBgn0037703	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	NP_192008.3	Gene:	AT4G00990 / 827933	AraportID:	AT4G00990	Length:	840	Species:	Arabidopsis thaliana

Alignment Length:	944	Identity:	230/944 - (24%)
Similarity:	348/944 - (36%)	Gaps:	311/944 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 VENPTLKAEQRVQQEEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPC--------FKLQQAQP 111
            ||:...::|::.:::|..:        ..:.|....|..|.:..:.:..        .|...::.
plant    18 VEDGRSESERKTRKKENDV--------VSKGRIGRGRGRGEVSKRSIEIDISNPEKDIKPDGSRK 74

  Fly   112 IAGSSPIPKCRECRRRNLATTEGEPSSVSD-VYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPE 175
            ..||:    |..|:   :.|:|      || ::|.....:...|:     |:   ...|||.:.|
plant    75 CLGST----CHHCK---ILTSE------SDLIFCSKCNKKCYCFD-----CI---KRSYSERTHE 118

  Fly   176 DI---------------AIWQPDKNTPPTSGYMDIQV--CRYILLHAGDQFCYIWHQEAEALSL- 222
            ::               .:..|....||:....|:::  .:|:|:........|:.::...|.:
plant   119 EVRAACPFCMMTCICRACLRLPLVIKPPSEKDTDVKLKQLQYLLVKVLPVLKDIYTEQNRELEIE 183

  Fly   223 -----HQNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTC--RKCGFGVCLDCVKDRKEGLRLRR 280
                 |..|:..|...|.....|..||:|.|::.|:|.:|  :.|...:||.|.|:..||....|
plant   184 STIRGHPVTEANIKRCKLDPSERIYCDLCRTSIANFHRSCPNKNCSVDICLSCCKELSEGFHQER 248

  Fly   281 --AENAAQKG--C----------DEY---H---WLLCSD---PSGPQEHVLTELMLTQIIAGDAL 322
              .:||..||  |          |.|   |   |.|.||   |..|:|           ..|...
plant   249 DGKKNAEGKGYECRIPAGQGKDSDAYVPLHFSTWKLNSDSSIPCPPKE-----------CGGCGT 302

  Fly   323 NVLGRLLHEVRTLWQVPQVCGCLLSKQAIEDAQS-----KEVIQDMIKESQLKQHTSYSSLASEQ 382
            :.|     |:|.||:...|      ::.|.:|:.     :....|::       |...|...:..
plant   303 STL-----ELRRLWKRDWV------EKLITNAEKCTLNFRPTDVDIV-------HECSSCSTNSD 349

  Fly   383 KVHQQQRLDQLHATKLEFARELGVDYVPGRVWTKETLGKDPITTAFDNLKHINFLRKGLAGLRRF 447
            .:.:|                                      .||....|.|||
plant   350 SIRRQ--------------------------------------AAFRKNAHDNFL---------- 366

  Fly   448 LPPRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLD 512
                     ||.....            |...|..|      ||..|...:||::..|....:..
plant   367 ---------YSPNAVD------------LAEDDIAH------FQFHWMKAEPVIVRNVLEKTSGL 404

  Fly   513 LWHPQAF---CRDFGDKPN---------DLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKP 565
            .|.|...   ||:...|..         ..::||:...|... :..|:||:  :..|: ...|.|
plant   405 SWEPMVMWRACREMDPKRKGTEEETTKVKALDCLDWCEVEIN-LHQFFEGY--LEGRM-HKNGWP 465

  Fly   566 MLLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYT-LRTGNLNIASCLPKMFVPPDLGPKMYNAY 629
            .:||||||||.|.|.:.||...|:.:..||..:|| .::|.||:|:..|:..:.||||||.|.||
plant   466 EMLKLKDWPPSDLFEKRLPRHNAEFIAALPFFDYTDPKSGILNLATRFPEGSLKPDLGPKTYIAY 530

  Fly   630 G--SALHPDKGTTNLHLDISDAVNIMVY---VGIP------------------------------ 659
            |  ..|:.....|.||.|||||||::.:   |.||
plant   531 GFHEELNRGDSVTKLHCDISDAVNVLTHTAKVEIPPVKYQNIKVHQKKYAEAMLQKQQYSGQVKE 595

  Fly   660 ------------------------------------------------QDGDTRPQMAATQKAIE 676
                                                            :|..|:|.::.:.::|:
plant   596 ASELENKSMKEVDESKKDLKDKAANEEQSNNSSRPSGSGEAEKVIISKEDNPTQPAVSTSVESIQ 660

  Fly   677 IGGCDY------ITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEKGFR------LEPDH 729
            ....|.      .|..|  |..|..||:|.||...|..|:...|.|  .|..||      ||...
plant   661 EQKLDAPKETDGNTNER--SKAVHGGAVWDIFRREDVPKLIQFLKR--HEHEFRHFNNEPLESVI 721

  Fly   730 DPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPEN 794
            .|||||..:|.|..:.:|.:|:.:|.....|.||:|||||||.||||:|..:|||||.|||:||:
plant   722 HPIHDQTMFLSDSQKKQLKEEFDIEPWTFEQHLGEAVFIPAGCPHQVRNRQSCIKVALDFVAPES 786

  Fly   795 ITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHA 828
            :..|..||.|||||...|::.||||::|.|..:|
plant   787 VEECLRLTQEFRRLPKDHSSSEDKLELKKIALYA 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JHDM2	NP_001287255.1	JmjC	605..657	CDD:214721	25/56 (45%)
JHDM2	NP_001287255.1	cupin_like	694..789	CDD:304367	44/100 (44%)
AT4G00990	NP_192008.3	zf-4CXXC_R1	76..>138	CDD:287469	15/82 (18%)
		JmjC	487..560	CDD:214721	31/72 (43%)
		cupin_like	683..781	CDD:304367	44/99 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	146	1.000	Domainoid score	I1460
eggNOG	1	0.900	-	-		E1_KOG1356
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	258	1.000	Inparanoid score	I987
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185631at2759
OrthoFinder	1	1.000	-	-		FOG0001431
OrthoInspector	1	1.000	-	-		otm2947
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12549
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970