Protein Alignment Kdm3 and Hr

DIOPT Version :10

• Sequence 1: NP_788611.1
• Gene: Kdm3 / 41143
• FlyBaseID: FBgn0037703
• Length: 854
• Species: Drosophila melanogaster
• Sequence 2: NP_001424170.1
• Gene: Hr / 60563
• RGDID: 620634
• Length: 1181
• Species: Rattus norvegicus
• Alignment Length: 845
• Identity: 221/845 - (26%)
• Similarity: 329/845 - (38%)
• Gaps: 179/845 - (21%)

  Fly    50 RACCEVENPTLKAEQRVQQEEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPCFKLQQAQPIAG 114
            ||..|....:..::...||:||..|     ..:.:.|..|.|      |:|..|     ...:||
  Rat   442 RAWQETPETSTGSKAEAQQQEEQRG-----PRDGRIRLRESR------LEDTSC-----QHHLAG 490

  Fly   115 SSPIPKCRECRRR-NLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIA 178
            .:..|.|.:.... .:.|:..:.|            .||...|              :|..||..
  Rat   491 VTQCPSCVQAAGEVEILTSHSQKS------------HRLPLEE--------------KPLEEDSC 529

  Fly   179 IWQPDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSLHQNTDGTIAWKKAVKGTREIC 243
            ....:.........::..:.:::|...||:.|.:..:|.|||:..|......|..:...|....|
  Rat   530 ATSEEGGGSSPEASINKGLAKHLLSGLGDRLCRLLRKEREALAWAQREGQGPAMTEDSPGIPHCC 594

  Fly   244 DVCDTTLFNYHWTCRKCGFGVCLDC------VKDR-KEGLRLRRAENAAQKGCDEYHWLLCSDPS 301
            ..|...|||.||.|..|...:|:.|      .|:| |.|.|.:|.::.||:.
  Rat   595 SRCHHGLFNTHWRCSHCSHRLCVACGRIAGAGKNREKTGSREQRTDDCAQEA------------- 646

  Fly   302 GPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGCLLSKQAI---EDAQSKEVIQ-- 361
               .|....|:|||.::..||..|..::|:|...:.:...|.|.:..:..   :..|.||..:
  Rat   647 ---GHAACSLILTQFVSSQALAELSTVMHQVWAKFDIRGHCFCQVDARVWAPGDGGQQKEPTEKT 708

  Fly   362 ----------DMIKESQLKQHT--SYSSLASEQKVHQQQRLDQL------HATKLEFARE-LGVD 407
                      |..:...:|:.|  |..|.|.::..........|      .|.||....| :.:.
  Rat   709 PPAPQLSCNGDSNRTKDIKEETPDSTESPAEDRAGRSPLPCPSLCELLASTAVKLCLGHERIHMA 773

  Fly   408 YVPGRVWTKETLGKDPITTAFDN------------------LKHINFLRKGLAGLRRFLPPRTMT 454
            :.|   .|......|.||...|:                  |:..:.|||||:     ||...:
  Rat   774 FAP---VTPALPSDDRITNILDSIIAQVVERKIQEKALGPGLRAGSGLRKGLS-----LPLSPV- 829

  Fly   455 FAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAF 519
               .|:|:|        .|.||.|.:........||||.|:.||||::|.:.::|.|.||..:|
  Rat   830 ---RTRLSP--------PGALLWLQEPRPKHGFRLFQEHWRQGQPVLVSGIQKTLRLSLWGMEA- 882

  Fly   520 CRDFGDKPNDLINCLNGN------LVPNQP----MRHFWEGFQCMTKRLPDAYGKPMLLKLKDWP 574
                       :..|.|.      |.|.||    ...||:||.....|.....|..:||..   |
  Rat   883 -----------LGTLGGQVQTLTALGPPQPTSLDSTAFWKGFSHPEARPKLDEGSVLLLHR---P 933

  Fly   575 PGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDK-G 638
            .||..    .:|..:|...||:|||....|.||:||.||.......|.|:::.|||...|... |
  Rat   934 LGDKD----ESRVENLASSLPLPEYCAHQGKLNLASYLPLGLTLHPLEPQLWAAYGVNSHRGHLG 994

  Fly   639 TTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFP 703
            |.||.:::||.::|:|:.    :....|...| ||.. :.|.|   .....||......:||:|.
  Rat   995 TKNLCVEVSDLISILVHA----EAQLPPWYRA-QKDF-LSGLD---GEGLWSPGSQTSTVWHVFR 1050

  Fly   704 ARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFI 768
            |:||.:||..|..|.......|||.    ...:.|||..||.||.:|:||....::|..|:||.:
  Rat  1051 AQDAQRIRRFLQMVCPAGAGTLEPG----APGSCYLDSGLRRRLREEWGVSCWTLLQAPGEAVLV 1111

  Fly   769 PAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKL---QIKNIIYHAIK 830
            |||||||||.|.:.|.|.:.|:|||.......|.|:...|...|     ::   |:...::.|:|
  Rat  1112 PAGAPHQVQGLVSTISVTQHFLSPETSALSAQLCHQGASLPPDH-----RMLYAQMDRAVFQAVK 1171

  Fly   831  830
              Rat  1172  1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm3	NP_788611.1	JmjC	605..657	CDD:214721	20/52 (38%)
		cupin_RmlC-like	694..789	CDD:477354	39/94 (41%)
Hr	NP_001424170.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..378
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..472		8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	509..543		7/59 (12%)
		LXXLL motif 1	560..564		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..745		9/48 (19%)
		LXXLL motif 2	752..756		1/3 (33%)