DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JHDM2 and jmjd1cb

DIOPT Version :9

Sequence 1:	NP_001287255.1	Gene:	JHDM2 / 41143	FlyBaseID:	FBgn0037703	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	XP_009304785.1	Gene:	jmjd1cb / 558436	ZFINID:	ZDB-GENE-121214-344	Length:	2569	Species:	Danio rerio

Alignment Length:	980	Identity:	325/980 - (33%)
Similarity:	483/980 - (49%)	Gaps:	203/980 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TRTSRKRTISSTSFSISTRTDPKSIIEIHIFNDSLPI----------KRACCEVENPTLK----- 61
            ||.:.||...|.|.|.......:|.:|........|.          ::...|.|...:|
Zfish  1637 TRRTPKRPYESCSESGDDSDSSESKLEQRTKRQPKPTYKKKQNDMQKRKGDNEKEEDEVKPNGIF 1701

  Fly    62 --AEQRVQQEEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCREC 124
              |:::.:.:..|...:|....::.::..:.:.:|..||||..|.::        ...:.|||||
Zfish  1702 RSAKEKTKLKLASTNGIPRSVLKDWRKVKKLKQTGESFLQDDSCTEI--------GPNLQKCREC 1758

  Fly   125 RRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGF--PNPYSEPSPEDIAIWQPD---K 184
              |::.|.:||..:.|.|:||||.||||.:::||.:.:.||  |:.|.|   |..:||..|   :
Zfish  1759 --RSIRTKKGEEPTHSPVFCRFYHFRRLSYSKNGVIRIDGFSSPDQYDE---EAHSIWASDAYEE 1818

  Fly   185 NTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSLHQNT-------DGTIAWKKAVKGTREI 242
            |.      :|::..:|||.:.||:||        .|.:.:||       |..||||:||:|.||.
Zfish  1819 NN------LDLETSKYILSYIGDKFC--------QLVMTENTATTWIKKDAKIAWKRAVRGVRES 1869

  Fly   243 CDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCSDPSGPQEHV 307
            ||.|:.||||.||.|:||||.|||||.|.:         |..:.|..:.|.||.|. ...|.:|
Zfish  1870 CDACEATLFNIHWVCQKCGFVVCLDCYKAK---------ERKSSKDKELYAWLKCV-KGQPHDH- 1923

  Fly   308 LTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGC------LLSKQAIEDAQSKE-VIQDMI- 364
             ..||.||||.|..|..|...:|.:|..:.:...|.|      |.:|....:..|:. |:|:::
Zfish  1924 -KHLMPTQIIPGTVLTDLVSAMHMLREKYSIKSHCSCAGKQNTLFNKLPSTNGVSQVCVLQNVLN 1987

  Fly   365 -------------KESQLK-QHTSYSSLAS------------------------EQKVHQQQR-- 389
                         :::.|| :....||.||                        |||..::::
Zfish  1988 HSNKISLCKPEGGQQNSLKVEANGGSSPASDTSTDSKFTPPESQSPLHFLADLAEQKSREEKKGG 2052

  Fly   390 --------------------------LDQLH--ATKLEFAREL------------------GVDY 408
                                      |:.||  |:.||....|                  |:.:
Zfish  2053 YRTIKLSENKESGVGKMKEEKDQSDALESLHSKASSLEQGSTLRDLLTTTAGKLRLGSTDAGIAF 2117

  Fly   409 VP-----------GRVWTKETLGKDPITTAFD-----------NLKHINFLRKGLAGLRRFL--P 449
            .|           ||  :...:..|.|.:..:           |||| ..|.:.....::.:  |
Zfish  2118 APVYSNASQIVKSGR--SMPNILDDIIASVVENKIPAGRGTKLNLKH-EPLEEPKVERKKAVEEP 2179

  Fly   450 PRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLW 514
            |:         |...:||.:|.:.:||.|.|..:..|..||:|.|:.||||::|.|.|.||..||
Zfish  2180 PK---------LYADIPHCWLYERKLLWLKDHRNSGNWKLFRECWRQGQPVLVSGVHRRLNASLW 2235

  Fly   515 HPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDF 579
            ..::|.::|.|...||:||.:| ::.|..::.||:||:.:|||.....|:.::.:|||||.|::|
Zfish  2236 KAESFNQEFADHQGDLLNCKDG-VMSNSGVKEFWDGFEDLTKRPKAKDGETVVYRLKDWPSGEEF 2299

  Fly   580 AEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSAL--HPDKGTTNL 642
            ..::|:|:.||||.||||||:...||||:||.||..||.|||||::..|||.|.  ..|.||.||
Zfish  2300 MALMPSRYDDLMKNLPMPEYSDPEGNLNLASHLPTFFVRPDLGPRLCCAYGVAASQEQDFGTANL 2364

  Fly   643 HLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDA 707
            |:::||.::::||||:.: |:.........|.:|....|...:.|.:.....|||||||:.::|.
Zfish  2365 HMEVSDVISVLVYVGVAK-GNGVLSKTGVLKRLEEEDLDDNVKKRLKDSSETPGALWHIYTSKDG 2428

  Fly   708 DKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGA 772
            :||::.|::|..|:|..:..|||||.|.::||..|||.||..|:|::|..:||.|||:|.|||||
Zfish  2429 EKIKEFLHKVAKEQGVEIAADHDPIRDSSYYLSRKLRQRLLDEHGIQGWTVVQFLGDSVLIPAGA 2493

  Fly   773 PHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTILT 837
            .|||||||:||:|..||||||::.|.:|||.|.|. |....|:|||||:|||.||.:||....|.
Zfish  2494 LHQVQNLHSCIQVINDFVSPEHVGHSFHLTQELRS-SKEEMNYEDKLQVKNIFYHCVKDAVGTLK 2557

  Fly   838 RAVDE 842
            |:..|
Zfish  2558 RSCAE 2562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JHDM2	NP_001287255.1	JmjC	605..657	CDD:214721	28/53 (53%)
JHDM2	NP_001287255.1	cupin_like	694..789	CDD:304367	51/94 (54%)
jmjd1cb	XP_009304785.1	JmjC	2309..2379	CDD:214721	39/69 (57%)
jmjd1cb	XP_009304785.1	cupin_like	2411..2510	CDD:304367	51/98 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185631at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26235
orthoMCL	1	0.900	-	-		OOG6_102953
Panther	1	1.100	-	-	O	PTHR12549
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X572
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850