Protein Alignment Kdm3 and KDM3A

DIOPT Version :10

• Sequence 1: NP_788611.1
• Gene: Kdm3 / 41143
• FlyBaseID: FBgn0037703
• Length: 854
• Species: Drosophila melanogaster
• Sequence 2: NP_060903.2
• Gene: KDM3A / 55818
• HGNCID: 20815
• Length: 1321
• Species: Homo sapiens
• Alignment Length: 895
• Identity: 365/895 - (40%)
• Similarity: 477/895 - (53%)
• Gaps: 173/895 - (19%)

  Fly    48 IKRACCEVENPTL--KAEQRVQQ--EEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPCFKLQQ 108
            :|.:..:|:|.:.  ::..::|.  ..:|:...|...::.||       ||..|:||..|..:
Human   484 LKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQ-------SGEAFVQDDSCVNI-- 539

  Fly   109 AQPIAGSSPIPKCRECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGF--PNPYSE 171
                  .:.:|||||||..:| ..:.|....|.|:|||:.|||||||::|.|.|.||  ||.|..
Human   540 ------VAQLPKCRECRLDSL-RKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDN 597

  Fly   172 PSPEDIAIWQP-DKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSL---HQNTDGTIAW 232
               |.|.:|.| .||...    :|:...:|||.:.||.||.:...|.||:|.   |:.    :||
Human   598 ---EAIGLWLPLTKNVVG----IDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQ----VAW 651

  Fly   233 KKAVKGTREICDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLC 297
            |:||||.||:|||||||:||.||.|.:||||||:||.:.:::..:    :.||.|   .:.||.|
Human   652 KRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQ----QGAAYK---TFSWLKC 709

  Fly   298 SDPSGPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGC------LLSKQAIEDAQS 356
            ..   .|.|....||.||||.|.||..:|.::|.||..|.:...|.|      |.||.|     |
Human   710 VK---SQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPA-----S 766

  Fly   357 KEVIQDMIKESQLKQHTSYSSLASEQ----KVHQQQRLDQLHATKLEFARELG------------ 405
            ||         .|||    :|||.|:    .|.||      :.:.||.|...|
Human   767 KE---------DLKQ----TSLAGEKPTLGAVLQQ------NPSVLEPAAVGGEAASKPAGSMKP 812

  Fly   406 ------------VDYVPGRVWTKETLGKDP-------------------------------ITTA 427
                        .|...|.| .||...|.|                               |.|.
Human   813 ACPASTSPLNWLADLTSGNV-NKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTP 876

  Fly   428 FDNLKHINFLR-----------KGLAGLRRFLP------------------PRTMTFAYSTQLAP 463
            ..| .:..|||           .||....:.|.                  |:.:|...|. |..
Human   877 VSN-NNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSI-LGF 939

  Fly   464 GVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPN 528
            ..||.:|||.|||.|.|..:..|..:|:|.||.|||||:|.|...||.:||.|::|.::||::..
Human   940 DTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGEQEV 1004

  Fly   529 DLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKG 593
            ||:||....::....:..||:||:.:..||.:. .:||:|||||||||:||.:::|:||.|||..
Human  1005 DLVNCRTNEIITGATVGDFWDGFEDVPNRLKNE-KEPMVLKLKDWPPGEDFRDMMPSRFDDLMAN 1068

  Fly   594 LPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDK--GTTNLHLDISDAVNIMVYV 656
            :|:||||.|.|.||:||.||..||.||||||||||||.....|:  ||||||||:|||.|:||||
Human  1069 IPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYV 1133

  Fly   657 GIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEK 721
            |||: |... |.....|.|:.|..|.:|..|.......|||||||:.|:|.:|||:.|.:|:.|:
Human  1134 GIPK-GQCE-QEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQ 1196

  Fly   722 GFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVA 786
            |.....||||||||:||||..||.||.:||||:|..|||.|||.|||||||||||.||::|||||
Human  1197 GQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVA 1261

  Fly   787 EDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTIL 836
            |||||||::.||:.||.|||.||.:|||||||||:||:||||:||...:|
Human  1262 EDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAML 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm3	NP_788611.1	JmjC	605..657	CDD:214721	36/53 (68%)
		cupin_RmlC-like	694..789	CDD:477354	62/94 (66%)
KDM3A	NP_060903.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..336
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..402
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..472
		LXXLL motif	885..889		2/3 (67%)
		JmjC	1064..1134	CDD:214721	46/69 (67%)
		cupin_RmlC-like	1151..1264	CDD:477354	66/112 (59%)