DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm3 and KDM3B

DIOPT Version :10

Sequence 1:NP_788611.1 Gene:Kdm3 / 41143 FlyBaseID:FBgn0037703 Length:854 Species:Drosophila melanogaster
Sequence 2:NP_057688.3 Gene:KDM3B / 51780 HGNCID:1337 Length:1761 Species:Homo sapiens


Alignment Length:995 Identity:382/995 - (38%)
Similarity:510/995 - (51%) Gaps:186/995 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSQKELAALVATRTSRKRTISSTSFS---ISTRTDPKSIIEIHIFNDSLPIKRACCEVENPTLKA 62
            :.::.||....:.:|....:|..|.|   :..:|..|.|.| |:.....|......|:    |..
Human   799 LDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPE-HLMGKLGPNGERSAEL----LLG 858

  Fly    63 EQRVQQEEESLGQVPPLTEEEQQRHD-----EFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCR 122
            :.:.:|..:...:..||...:....|     :.:.||..||||..|..:        :..:.|||
Human   859 KSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINV--------APHLHKCR 915

  Fly   123 ECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQPDKNTP 187
            |||.......:.:....|.|.|||:.||||.|...|.|.|.||.:| .:..|:.:.:|.|..:. 
Human   916 ECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLSP-QQSDPDAMNLWIPSSSL- 978

  Fly   188 PTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSL---HQNTDGTIAWKKAVKGTREICDVCDTT 249
             ..| :|::..:|||.:.|||||.:...|.||:.:   ||.    :|||:||:|.||:||||:||
Human   979 -AEG-IDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQK----VAWKRAVRGVREMCDVCETT 1037

  Fly   250 LFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDE-YHWLLCSDPSGPQEHVLTELML 313
            |||.||.||||||||||||.:.||.    |......:.|.:| :.||.|:.   .|.|....||.
Human  1038 LFNIHWVCRKCGFGVCLDCYRLRKS----RPRSETEEMGDEEVFSWLKCAK---GQSHEPENLMP 1095

  Fly   314 TQIIAGDALNVLGRLLHEVRTLWQVPQVCGCL--LSKQAIEDAQSKEVIQ--------------- 361
            ||||.|.||..:|.::|..|..|.:...|.|:  .:|..:..|.:..:.|               
Human  1096 TQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQNKSVLRPAVTNGMSQLPSINPSASSGNETT 1160

  Fly   362 ------------------------DMIKESQLKQHTSYSSLASEQKVHQQQRLD------QLH-- 394
                                    |:..|..||..:|.|:..||.|..:....|      .||  
Human  1161 FSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASNSNSELKAIRPPCPDTAPPSSALHWL 1225

  Fly   395 ---ATK--LEFARELGVDYVPGRVWTKET---LGKD---------PIT-----------TAFDNL 431
               ||:  .|..:|.|   ....|..||:   .|.|         |:|           ||.:|.
Human  1226 ADLATQKAKEETKEAG---SLRSVLNKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTASNNK 1287

  Fly   432 KHINFLR--------------------------------KGLAGLRRFL---------------- 448
            ...:.||                                |..|.|..||                
Human  1288 TEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSTSSAGVKSKASLPNFLDHIIASVVENKKTSDA 1352

  Fly   449 ------------PPRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVM 501
                        ..:.|....:. |.|...|.:|||||||.|.|..:.:|..:|:|.||.||||:
Human  1353 SKRACNLTDTQKEVKEMVMGLNV-LDPHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVL 1416

  Fly   502 ISEVARSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPM 566
            :|.|.:.|..:||.|:||.::|||:..||:||.|..::.:..:|.||:||:.:.|||....|:||
Human  1417 VSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPM 1481

  Fly   567 LLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGS 631
            :|||||||||:||.:::||||.|||:.||:||||.|.|.||:||.||..||.||||||||||||.
Human  1482 VLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGL 1546

  Fly   632 ALHPDK--GTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVL 694
            ....|:  ||||||||:|||||:|||||||.......:  ...|.|:.|..|.:|:.|.......
Human  1547 ITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDE--EVLKTIDEGDADEVTKQRIHDGKEK 1609

  Fly   695 PGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIV 759
            |||||||:.|:||:|||:||.:|..|:|....|||||||||:||||..||.||::||||:|..||
Human  1610 PGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIV 1674

  Fly   760 QCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNI 824
            |.|||||||||||||||.||::||||||||||||::.||:.||.|||.||::|||||||||:|||
Human  1675 QFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNI 1739

  Fly   825 IYHAIKDCCTILTRAVDERL 844
            ||||:||....| :|.:.:|
Human  1740 IYHAVKDAVGTL-KAHESKL 1758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm3NP_788611.1 JmjC 605..657 CDD:214721 37/53 (70%)
cupin_RmlC-like 694..789 CDD:477354 66/94 (70%)
KDM3BNP_057688.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..346
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..394
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..496
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 572..603
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 714..762
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 805..827 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1142..1220 11/77 (14%)
LXXLL motif 1293..1297 2/3 (67%)
JmjC 1502..1574 CDD:214721 49/71 (69%)
cupin_RmlC-like 1599..1704 CDD:477354 68/104 (65%)
Blue background indicates that the domain is not in the aligned region.

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