DRSC/TRiP Functional Genomics Resources

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Protein Alignment JHDM2 and KDM3B

DIOPT Version :9

Sequence 1:NP_001287255.1 Gene:JHDM2 / 41143 FlyBaseID:FBgn0037703 Length:854 Species:Drosophila melanogaster
Sequence 2:NP_057688.3 Gene:KDM3B / 51780 HGNCID:1337 Length:1761 Species:Homo sapiens


Alignment Length:995 Identity:382/995 - (38%)
Similarity:510/995 - (51%) Gaps:186/995 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSQKELAALVATRTSRKRTISSTSFS---ISTRTDPKSIIEIHIFNDSLPIKRACCEVENPTLKA 62
            :.::.||....:.:|....:|..|.|   :..:|..|.|.| |:.....|......|:    |..
Human   799 LDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPE-HLMGKLGPNGERSAEL----LLG 858

  Fly    63 EQRVQQEEESLGQVPPLTEEEQQRHD-----EFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCR 122
            :.:.:|..:...:..||...:....|     :.:.||..||||..|..:        :..:.|||
Human   859 KSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINV--------APHLHKCR 915

  Fly   123 ECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQPDKNTP 187
            |||.......:.:....|.|.|||:.||||.|...|.|.|.||.:| .:..|:.:.:|.|..:. 
Human   916 ECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLSP-QQSDPDAMNLWIPSSSL- 978

  Fly   188 PTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSL---HQNTDGTIAWKKAVKGTREICDVCDTT 249
             ..| :|::..:|||.:.|||||.:...|.||:.:   ||.    :|||:||:|.||:||||:||
Human   979 -AEG-IDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQK----VAWKRAVRGVREMCDVCETT 1037

  Fly   250 LFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDE-YHWLLCSDPSGPQEHVLTELML 313
            |||.||.||||||||||||.:.||.    |......:.|.:| :.||.|:.   .|.|....||.
Human  1038 LFNIHWVCRKCGFGVCLDCYRLRKS----RPRSETEEMGDEEVFSWLKCAK---GQSHEPENLMP 1095

  Fly   314 TQIIAGDALNVLGRLLHEVRTLWQVPQVCGCL--LSKQAIEDAQSKEVIQ--------------- 361
            ||||.|.||..:|.::|..|..|.:...|.|:  .:|..:..|.:..:.|               
Human  1096 TQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQNKSVLRPAVTNGMSQLPSINPSASSGNETT 1160

  Fly   362 ------------------------DMIKESQLKQHTSYSSLASEQKVHQQQRLD------QLH-- 394
                                    |:..|..||..:|.|:..||.|..:....|      .||  
Human  1161 FSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASNSNSELKAIRPPCPDTAPPSSALHWL 1225

  Fly   395 ---ATK--LEFARELGVDYVPGRVWTKET---LGKD---------PIT-----------TAFDNL 431
               ||:  .|..:|.|   ....|..||:   .|.|         |:|           ||.:|.
Human  1226 ADLATQKAKEETKEAG---SLRSVLNKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTASNNK 1287

  Fly   432 KHINFLR--------------------------------KGLAGLRRFL---------------- 448
            ...:.||                                |..|.|..||                
Human  1288 TEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSTSSAGVKSKASLPNFLDHIIASVVENKKTSDA 1352

  Fly   449 ------------PPRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVM 501
                        ..:.|....:. |.|...|.:|||||||.|.|..:.:|..:|:|.||.||||:
Human  1353 SKRACNLTDTQKEVKEMVMGLNV-LDPHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVL 1416

  Fly   502 ISEVARSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPM 566
            :|.|.:.|..:||.|:||.::|||:..||:||.|..::.:..:|.||:||:.:.|||....|:||
Human  1417 VSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPM 1481

  Fly   567 LLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGS 631
            :|||||||||:||.:::||||.|||:.||:||||.|.|.||:||.||..||.||||||||||||.
Human  1482 VLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGL 1546

  Fly   632 ALHPDK--GTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVL 694
            ....|:  ||||||||:|||||:|||||||.......:  ...|.|:.|..|.:|:.|.......
Human  1547 ITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDE--EVLKTIDEGDADEVTKQRIHDGKEK 1609

  Fly   695 PGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIV 759
            |||||||:.|:||:|||:||.:|..|:|....|||||||||:||||..||.||::||||:|..||
Human  1610 PGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIV 1674

  Fly   760 QCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNI 824
            |.|||||||||||||||.||::||||||||||||::.||:.||.|||.||::|||||||||:|||
Human  1675 QFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNI 1739

  Fly   825 IYHAIKDCCTILTRAVDERL 844
            ||||:||....| :|.:.:|
Human  1740 IYHAVKDAVGTL-KAHESKL 1758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JHDM2NP_001287255.1 JmjC 605..657 CDD:214721 37/53 (70%)
cupin_like 694..789 CDD:304367 66/94 (70%)
KDM3BNP_057688.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..346
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..394
Herpes_BLLF1 <424..756 CDD:330317
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..496
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 572..603
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 714..762
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 805..828 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1142..1220 11/77 (14%)
LXXLL motif 1293..1297 2/3 (67%)
JmjC 1502..1574 CDD:214721 49/71 (69%)
cupin_like 1599..1704 CDD:328732 68/104 (65%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156658
Domainoid 1 1.000 403 1.000 Domainoid score I722
eggNOG 1 0.900 - - E1_KOG1356
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 606 1.000 Inparanoid score I936
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1185631at2759
OrthoFinder 1 1.000 - - FOG0001431
OrthoInspector 1 1.000 - - otm41741
orthoMCL 1 0.900 - - OOG6_102953
Panther 1 1.100 - - LDO PTHR12549
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X572
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.760

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