DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JHDM2 and kdm3b

DIOPT Version :9

Sequence 1:	NP_001287255.1	Gene:	JHDM2 / 41143	FlyBaseID:	FBgn0037703	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	XP_005173195.1	Gene:	kdm3b / 326643	ZFINID:	ZDB-GENE-101007-4	Length:	1824	Species:	Danio rerio

Alignment Length:	962	Identity:	359/962 - (37%)
Similarity:	485/962 - (50%)	Gaps:	207/962 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ENPTLKAEQRVQQEEESLGQVPPLTE---------EEQQRHDEFRNSGSIFLQDLPCFKLQQAQP 111
            :.|.|.|....:.:.::..:..|.::         ::|.:....:.||..||||..|..:
Zfish   879 QKPDLPAGNEDKNKAQAAAKSRPRSKPFKVGQSVLKDQNKVRRLKQSGEAFLQDGSCINV----- 938

  Fly   112 IAGSSPIPKCRECRRRNLATTEGEPSSVSD--VYCRFYEFRRLQFNENGELCVVGFPNPYSEPSP 174
               :..:.||||||......:..:.|...|  |.|||:.||||.|.:.|.|.|.||.:|....|.
Zfish   939 ---APHLHKCRECRLERYRKSREQDSDDDDPNVACRFFHFRRLAFTKKGVLRVEGFLSPQQSDSM 1000

  Fly   175 EDIAIWQPDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSL---HQNTDGTIAWKKAV 236
            . :.:|.|.......   :|:...:|||.:.|||||.:...|.||:.:   ||.    :|||:||
Zfish  1001 A-MGLWLPSITIQEG---LDLDTSKYILANVGDQFCQLVMSEKEAMMMVEPHQK----VAWKRAV 1057

  Fly   237 KGTREICDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCS--D 299
            :|.||:||||:|||||.||.||||||||||||.:.||.  |....|:..::  :.:.||.|:  .
Zfish  1058 RGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKN--RPPEVEDGPEE--EVFSWLKCAKGQ 1118

  Fly   300 PSGPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGC-------------------- 344
            |..||     .||.||||.|.||..:|.::|..|..|.:...|.|
Zfish  1119 PHEPQ-----NLMPTQIIPGTALYSIGDMVHAARGKWGIKANCPCTSRHKTLMRPSAPNGLSQSG 1178

  Fly   345 --------------------------LLSKQAIEDAQSKEVIQD--------------------- 362
                                      ::..:.:|:..|.:....
Zfish  1179 AAHSSGNGTTSTSSTTRPNEESAAGVVVKTEPVEEPTSADTTSSTSGTNSSTSSPAPAPTSAPTL 1243

  Fly   363 --------------------MIKESQLKQHTSYSS-------LASEQKVHQQQR----------- 389
                                ::.....|...|.||       ||::::..:..|
Zfish  1244 LPPSLPPPSLPPPSLPPAPALVPTPPAKDSKSSSSALHWLADLATQKEPKESLRSMMGRDSRSPF 1308

  Fly   390 -LDQL--------HATKLEFARELG----------------VDYVPGRVWTKETLGKDPITTAFD 429
             ||..        .:.||..:..||                ::...|::....|.|..|....|.
Zfish  1309 GLDSFSTLSKPSGSSPKLFNSLLLGAGPSQPKAEGTSLRDLLNSGSGKLPQGPTEGGVPFPPVFS 1373

  Fly   430 NLKHINFLRKGL----------------AGLRR-----------FLPPRTMTFAYSTQLAPGVPH 467
            .....:.::.||                :.:||           ..|.|......|. |.|...|
Zfish  1374 TASQADKMKGGLPNFLDHIIASVVETKKSEVRRASGSAEVIESATAPRREGVMGLSV-LDPHTSH 1437

  Fly   468 EFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPNDLIN 532
            .:|||||||.|.|..:|:|..:|:|.||.||||::|.:.|.|...||.|:||..:|||:..||:|
Zfish  1438 SWLCDGRLLCLQDPSNPNNWKIFRECWKQGQPVLVSGIHRKLKEHLWRPEAFSEEFGDQDVDLVN 1502

  Fly   533 CLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKGLPMP 597
            |.|..::.:..:|.||:|||.::|||..:.|:||:|||||||||:||.:::||||.|||..||:|
Zfish  1503 CRNCAIISDVKVREFWDGFQVISKRLQGSDGQPMVLKLKDWPPGEDFRDMMPTRFNDLMDNLPLP 1567

  Fly   598 EYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDK--GTTNLHLDISDAVNIMVYVGIPQ 660
            |||.|.|.||:||.||..||.||||||||||||.....|:  ||||||||:|||||:|||||||:
Zfish  1568 EYTKRDGRLNLASRLPNFFVRPDLGPKMYNAYGLISTEDRKVGTTNLHLDVSDAVNVMVYVGIPE 1632

  Fly   661 ---DGDTRPQMAA---TQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTL 719
               |.::...:|.   ..:.||.|..|.:|:.|.......|||||||:.|:||:|||:||.:|..
Zfish  1633 GENDQESEADLAGFKEVMQTIEEGDVDDMTKRRVYEIKEKPGALWHIYAAKDAEKIRELLRKVGE 1697

  Fly   720 EKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIK 784
            |:|....|||||||||:||||..||.||::||||:|..|||.|||||||||||||||.||::|||
Zfish  1698 EQGQENPPDHDPIHDQSWYLDQTLRRRLYEEYGVQGWSIVQFLGDAVFIPAGAPHQVHNLYSCIK 1762

  Fly   785 VAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTIL 836
            .||||||||::.||:.||.|||.||::|||||||||:|||||||:||....|
Zfish  1763 AAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVATL 1814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JHDM2	NP_001287255.1	JmjC	605..657	CDD:214721	37/53 (70%)
JHDM2	NP_001287255.1	cupin_like	694..789	CDD:304367	65/94 (69%)
kdm3b	XP_005173195.1	JmjC	1559..1629	CDD:214721	48/69 (70%)
kdm3b	XP_005173195.1	cupin_like	1675..1767	CDD:304367	63/91 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592276
Domainoid	1	1.000	140	1.000	Domainoid score	I4705
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185631at2759
OrthoFinder	1	1.000	-	-		FOG0001431
OrthoInspector	1	1.000	-	-		otm26235
orthoMCL	1	0.900	-	-		OOG6_102953
Panther	1	1.100	-	-	LDO	PTHR12549
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X572
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.850