Protein Alignment Kdm3 and Kdm3a

DIOPT Version :10

• Sequence 1: NP_788611.1
• Gene: Kdm3 / 41143
• FlyBaseID: FBgn0037703
• Length: 854
• Species: Drosophila melanogaster
• Sequence 2: NP_001376169.1
• Gene: Kdm3a / 312440
• RGDID: 708351
• Length: 1323
• Species: Rattus norvegicus
• Alignment Length: 909
• Identity: 356/909 - (39%)
• Similarity: 483/909 - (53%)
• Gaps: 161/909 - (17%)

  Fly    15 SRKRTISSTSFSISTRTDPKSIIEIHIFNDSLPIKRACCEVENPTLKAEQRVQQEEESLGQVPP- 78
            |:.:.:..||              :.:.:||     .|....|.|               |.||
  Rat   479 SQSQNLKETS--------------VKVDHDS-----CCTRSSNKT---------------QTPPA 509

  Fly    79 ----LTEEEQQRHDEFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCRECRRRNLATTEGEPSSV 139
                ||:.::.:  :.:.||..|:||..|..:        .:.:|||||||..:|...:.:...
  Rat   510 RKSVLTDPDKLK--KLQQSGEAFVQDDSCVNI--------VAQLPKCRECRLDSLRKDKDQQKD- 563

  Fly   140 SDVYCRFYEFRRLQFNENGELCVVGF--PNPYSEPSPEDIAIWQP-DKNTPPTSGYMDIQVCRYI 201
            |.|:|||:.|||||||::|.|.|.||  ||.|..   |.|.:|.| .||...|    |:...:||
  Rat   564 SPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDS---EAIGLWLPLTKNVVGT----DLDTAKYI 621

  Fly   202 LLHAGDQFCYIWHQEAEALSL---HQNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTCRKCGFG 263
            |.:.||.||.:...|.||:|.   |:.    :|||:||||.||:|||||||:||.||.|.:||||
  Rat   622 LANIGDHFCQMVISEKEAMSTIEPHRQ----VAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFG 682

  Fly   264 VCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCSDPSGPQEHVLTELMLTQIIAGDALNVLGRL 328
            ||:||.:.:::..:    :.||.|   .:.|:.|..   .|.|....||.||||.|.||..:|.:
  Rat   683 VCVDCYRMKRKNCQ----QGAAYK---TFSWIRCVK---SQIHEPENLMPTQIIPGKALYDVGDI 737

  Fly   329 LHEVRTLWQVPQVCGC------LLSKQAIED-------AQSKEVIQDMIKESQ-LKQHTSYSSLA 379
            :|.||..|.:...|.|      |.||.|:::       :..|..:..|:::|. :.:..:....|
  Rat   738 VHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQASLSGEKPSLGTMVQQSSPVLEPAAVCGEA 802

  Fly   380 SEQKVHQQQRLDQLHATKLEFARELGVDYVPGRVWTKETLGKD-----------------PITTA 427
            ..:.....:.:...:.:.|.:.    .|...|.| .||...|.                 |:..:
  Rat   803 PSKPASNVKPICPANTSPLNWL----ADLTSGNV-NKENKEKQLTMPILKNEIKCLPPLPPLNKS 862

  Fly   428 FDNLKHIN-------------FLR-----------KGLAGLRRFLP------------------P 450
            ...|...|             |||           .||....:.|.                  |
  Rat   863 STVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTSSDLSKRP 927

  Fly   451 RTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWH 515
            :.:|...|. |....||.:|||.|||.|.|..:..|..:|:|.||.|||||:|.|...||.:||.
  Rat   928 QGLTIKPSI-LGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWK 991

  Fly   516 PQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGK-PMLLKLKDWPPGDDF 579
            |::|.::||::..||:||....::....:..||:||:.:..||.:...| ||:|||||||||:||
  Rat   992 PESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEKEPMVLKLKDWPPGEDF 1056

  Fly   580 AEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDK--GTTNL 642
            .:::|:||.|||..:|:||||.|.|.||:||.||..||.||||||||||||.....|:  |||||
  Rat  1057 RDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNL 1121

  Fly   643 HLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDA 707
            |||:|||.|:|||||||: |... |.....:.|:.|..|.:|..|.......|||||||:.|:|.
  Rat  1122 HLDVSDAANVMVYVGIPK-GQCE-QEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDT 1184

  Fly   708 DKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGA 772
            :|||:.|.:|:.|:|.....||||||||:||||..||.||::||||:|..|||.|||.|||||||
  Rat  1185 EKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGA 1249

  Fly   773 PHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTIL 836
            ||||.||::||||||||||||::.||:.||.|||.||.:|||||||||:||:||||:||...:|
  Rat  1250 PHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRHLSQTHTNHEDKLQVKNVIYHAVKDAVAML 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm3	NP_788611.1	JmjC	605..657	CDD:214721	36/53 (68%)
		cupin_RmlC-like	694..789	CDD:477354	62/94 (66%)
Kdm3a	NP_001376169.1	JmjC	1066..1136	CDD:214721	46/69 (67%)
		JmjC	1153..1266	CDD:396791	66/112 (59%)