DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JHDM2 and Kdm3b

DIOPT Version :9

Sequence 1:	NP_001287255.1	Gene:	JHDM2 / 41143	FlyBaseID:	FBgn0037703	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	NP_001074725.1	Gene:	Kdm3b / 277250	MGIID:	1923356	Length:	1762	Species:	Mus musculus

Alignment Length:	1009	Identity:	379/1009 - (37%)
Similarity:	506/1009 - (50%)	Gaps:	214/1009 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQKELAALVATRTSRKRTISSTSFSISTRTDPKSIIEI---------HIFNDSLPIKRACCEVE 56
            :.::.||.       |:.:.|||:..:|..:|.:..::.         |:.....|......|:
Mouse   800 LDERSLAC-------RQDSDSSTNSDLSDLSDSEEQLQAKSGLKGIPEHLMGKLGPNGERSAEL- 856

  Fly    57 NPTLKAEQRVQQEEESLGQVPPLTEEEQQRHD-----EFRNSGSIFLQDLPCFKLQQAQPIAGSS 116
               |..:.:.:|..:...:..||...:....|     :.:.||..||||..|..:        :.
Mouse   857 ---LLGKGKGKQAPKGRPRTAPLKVGQSVLKDVSKVRKLKQSGEPFLQDGSCINV--------AP 910

  Fly   117 PIPKCRECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQ 181
            .:.||||||.......:.:....|.|.|||:.||||.|...|.|.|.||.:| .:..|:.:.:|.
Mouse   911 HLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLVFTRKGVLRVEGFLSP-QQSDPDAMNLWI 974

  Fly   182 PDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSL---HQNTDGTIAWKKAVKGTREIC 243
            |..:.  ..| :|::..:|||.:.|||||.:...|.||:.:   ||.    :|||:||:|.||:|
Mouse   975 PSSSL--AEG-IDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQK----VAWKRAVRGVREMC 1032

  Fly   244 DVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDE-YHWLLCSDPSGPQEHV 307
            |||:|||||.||.||||||||||||.:.||.    |......:.|.:| :.||.|:.   .|.|.
Mouse  1033 DVCETTLFNIHWVCRKCGFGVCLDCYRLRKS----RPRSETEEMGDEEVFSWLKCAK---GQSHE 1090

  Fly   308 LTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGCL--LSKQAIEDAQSKEVIQ--------- 361
            ...||.||||.|.||..:|.::|..|..|.:...|.|:  .||..:..|.:..:.|
Mouse  1091 PENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQSKSVLRPAVTNGISQLPSVTPSAS 1155

  Fly   362 ------------------------------DMIKESQLKQHTSYSSLASEQKV------------ 384
                                          |...|..||...|.|:..||.|.
Mouse  1156 SGNETTFSSGGGAAAVTNPEPDQVPKGAGTDGRSEEPLKAEGSASNSNSELKAIRPPCPDTAPPS 1220

  Fly   385 --------------------------------HQQQRLDQLHAT--------KLEFARELG---- 405
                                            |....||..::|        ||..:..||
Mouse  1221 SALHWLADLATQKAKEETKDAGSLRSVLNKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTAS 1285

  Fly   406 ------------VDYVPGRVWTKETLGKDPITTAFDNLKHINF---------LRKGLAGLRRFL- 448
                        :...||:      |.:.|:.|.      |.|         :.|..|.|..||
Mouse  1286 NSKTEGSSLRDLLHSGPGK------LPQTPLDTG------IPFPPVFSSSSAVAKSKASLPDFLD 1338

  Fly   449 --------------PPRTMTFAYSTQ------------LAPGVPHEFLCDGRLLRLTDAMHPDNR 487
                          |.:.......||            |.|...|.:|||||||.|.|..:.:|.
Mouse  1339 HIIASVVENKKTSDPSKRSCNLTDTQKEVKEMAMGLNVLDPHTSHSWLCDGRLLCLHDPSNKNNW 1403

  Fly   488 VLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQ 552
            .:|:|.||.||||::|.|.:.|..:||.|:||.::|||:..||:||.|..::.:..:|.||:||:
Mouse  1404 KIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFE 1468

  Fly   553 CMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFV 617
            .:.|||....|:||:|||||||||:||.:::||||.|||:.||:||||.|.|.||:||.||..||
Mouse  1469 IICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFV 1533

  Fly   618 PPDLGPKMYNAYGSALHPDK--GTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGC 680
            .||||||||||||.....|:  ||||||||:|||||:|||||||.......:  ...|.|:.|..
Mouse  1534 RPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPVGEGAHDE--EVLKTIDEGDA 1596

  Fly   681 DYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRA 745
            |.:|:.|.......|||||||:.|:||:|||:||.:|..|:|....|||||||||:||||..||.
Mouse  1597 DEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQILRK 1661

  Fly   746 RLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSH 810
            |||:||||:|..|||.|||||||||||||||.||::||||||||||||::.||:.||.|||.||:
Mouse  1662 RLFEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSN 1726

  Fly   811 SHTNHEDKLQIKNIIYHAIKDCCTILTRAVDERL 844
            :|||||||||:|||||||:||....| :|.:.:|
Mouse  1727 THTNHEDKLQVKNIIYHAVKDAVGTL-KAHESKL 1759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JHDM2	NP_001287255.1	JmjC	605..657	CDD:214721	37/53 (70%)
JHDM2	NP_001287255.1	cupin_like	694..789	CDD:304367	67/94 (71%)
Kdm3b	NP_001074725.1	JmjC	1503..1575	CDD:214721	49/71 (69%)
Kdm3b	NP_001074725.1	cupin_like	1600..1705	CDD:304367	69/104 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847068
Domainoid	1	1.000	411	1.000	Domainoid score	I688
eggNOG	1	0.900	-	-		E1_KOG1356
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	644	1.000	Inparanoid score	I800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185631at2759
OrthoFinder	1	1.000	-	-		FOG0001431
OrthoInspector	1	1.000	-	-		otm43788
orthoMCL	1	0.900	-	-		OOG6_102953
Panther	1	1.100	-	-	LDO	PTHR12549
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7411
SonicParanoid	1	1.000	-	-		X572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790