DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JHDM2 and Jmjd1c

DIOPT Version :9

Sequence 1:	NP_001287255.1	Gene:	JHDM2 / 41143	FlyBaseID:	FBgn0037703	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	XP_006513098.1	Gene:	Jmjd1c / 108829	MGIID:	1918614	Length:	2531	Species:	Mus musculus

Alignment Length:	988	Identity:	315/988 - (31%)
Similarity:	483/988 - (48%)	Gaps:	207/988 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ISSTSFSISTRTDPKSIIEIHIFNDSLPIKRACCEVEN-----------------------PTLK 61
            |:|||..|..|.|.:..::.:..::.:..::|....|:                       ||.|
Mouse  1579 IASTSNDIENRADGRVAVDKYGRDEKVSRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYK 1643

  Fly    62 AEQRVQQ------EEES----------------------LGQVPPLTEEEQQRHDEFRNSGSIFL 98
            .:|...|      ||:|                      ...||....::.::..:.:.:|..||
Mouse  1644 KKQNDLQKRKGEVEEDSKPNGVLSRSAKDKSKLKLQNSNSAGVPRSVLKDWRKVKKLKQTGESFL 1708

  Fly    99 QDLPCFKLQQAQPIAGSSPIPKCRECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVV 163
            ||..|.::        ...:.||||||.  :.:.:||.|:.|.|:||||.||||.|::||.:.:.
Mouse  1709 QDDSCCEI--------GPNLQKCRECRL--IRSKKGEESTHSPVFCRFYYFRRLSFSKNGVVRID 1763

  Fly   164 GFPNPYSEPSPEDIAIW-----QPDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSLH 223
            ||.:| .:...|.:::|     :.|:        :|::..:|||...||:||.:...|..|||..
Mouse  1764 GFSSP-DQYDDEAMSLWTHENYEDDE--------VDVETSKYILDIIGDKFCQLVTSEKTALSWV 1819

  Fly   224 QNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKG 288
            :. |..||||:||:|.||:||.|:.||||.||.||||||..||||.|.:         |..:.:.
Mouse  1820 KK-DAKIAWKRAVRGVREMCDACEATLFNVHWVCRKCGFVACLDCYKAK---------ERKSSRD 1874

  Fly   289 CDEYHWLLCSDPSGPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGCLLSKQAIED 353
            .:.|.|:.|. ...|.:|  ..|||||||.|..|..|...:|.:|..:.:...|.| .::|.::.
Mouse  1875 KELYAWMKCV-KGQPHDH--KHLMLTQIIPGSVLTDLLDAMHILREKYGIKSHCHC-TNRQNLQG 1935

  Fly   354 AQ------SKEVIQDMI-------------------KESQLKQHTSYSSLASEQKV--------- 384
            ..      ..:|:|:::                   ::||...::|..|.:::.::
Mouse  1936 GNVPTMNGVSQVLQNVLHHSNKTSVSLPESQQQNSPQKSQTNGNSSPGSASTDSRLTPPESQSPL 2000

  Fly   385 -------HQQQRLDQLHATKLEFARELGVD------------YVPGRVWTKE---TLGKDPITTA 427
                   .|:.|.::....:....||:..|            ..|....:.|   || :|.:||.
Mouse  2001 HWLADLAEQKSREEKQENKEFTLEREIKEDGDQDASDSPNGSTSPPASQSNEQGSTL-RDLLTTT 2064

  Fly   428 FDNLKHINFLRKGLAGLRRFLP-------------------------------PRTMTFAYSTQL 461
            ...|: :.....|:|    |.|                               |...|...:.:.
Mouse  2065 AGKLR-VGSTDAGIA----FAPVYSMGTSSGKGGRTMPNILDDIIASVVENKIPPNKTSKINIKS 2124

  Fly   462 APG--------------------VPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVA 506
            .|.                    :||.::||..:|.|.|..:.:|..||:|.||.|||.::|.|.
Mouse  2125 EPNEEPKESSLPATDESNKSYRDIPHSWICDQHILWLKDYKNSNNWKLFKECWKQGQPAVVSGVH 2189

  Fly   507 RSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLK 571
            :.:|:.||..::...||||...||:|| ..::|.|..::.||:||:.::||..:..|:.::||||
Mouse  2190 KKMNISLWKAESISLDFGDHQADLLNC-KDSIVSNANVKEFWDGFEEVSKRQKNKGGETVVLKLK 2253

  Fly   572 DWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYG--SALH 634
            |.|.|:||..::|||:.|.::.||:|||....|..|:||.||..||.|||||::.:|||  :|..
Mouse  2254 DCPSGEDFKAMMPTRYEDFLRCLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKD 2318

  Fly   635 PDKGTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALW 699
            .|.||||||::.||.||::|||||.: |:.....|...|..|....|.:.|.|.:....:|||||
Mouse  2319 HDIGTTNLHIEASDVVNVLVYVGIAK-GNGVLSKAGILKKFEEEELDDVLRKRLKDSSEIPGALW 2382

  Fly   700 HIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGD 764
            ||:..:|.||||:.|.:::.|:|..:.|:||||.||:||::.|||.||.:||||....::|.|||
Mouse  2383 HIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNRKLRQRLLEEYGVRACTLIQFLGD 2447

  Fly   765 AVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAI 829
            |:.:|||..|||||.|:|::|.|||||||::...:|||.|.|.|. ...|::||||:|||:|||:
Mouse  2448 AIVLPAGTLHQVQNFHSCVQVTEDFVSPEHLVQSFHLTQELRLLK-EEINYDDKLQVKNILYHAV 2511

  Fly   830 KDCCTILTRAVDE 842
            |:....|....||
Mouse  2512 KEMVRALKMHEDE 2524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JHDM2	NP_001287255.1	JmjC	605..657	CDD:214721	29/53 (55%)
JHDM2	NP_001287255.1	cupin_like	694..789	CDD:304367	50/94 (53%)
Jmjd1c	XP_006513098.1	AvrE	1066..>1260	CDD:338078
		JmjC	2287..2341	CDD:214721	29/53 (55%)
		cupin_like	2373..2472	CDD:389752	50/98 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1356
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	644	1.000	Inparanoid score	I800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185631at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43788
orthoMCL	1	0.900	-	-		OOG6_102953
Panther	1	1.100	-	-	O	PTHR12549
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.760