DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JHDM2 and kdm3b

DIOPT Version :9

Sequence 1:	NP_001287255.1	Gene:	JHDM2 / 41143	FlyBaseID:	FBgn0037703	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	XP_002936894.1	Gene:	kdm3b / 100135177	XenbaseID:	XB-GENE-5883749	Length:	1693	Species:	Xenopus tropicalis

Alignment Length:	968	Identity:	376/968 - (38%)
Similarity:	506/968 - (52%)	Gaps:	161/968 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TRTSRKRTISSTSFSISTRTDPKSIIEIHIFNDSLP---IKRACCEVEN--PTLKAEQRVQQEEE 71
            :|||::.:.|||:..:|..:|.:..:...|....:|   :.|.....|.  ..|.|:.|.:|..:
Frog   749 SRTSKQDSDSSTNSDLSDLSDSEEQLNSKIGYRGIPEHLVGRLGHNGERNVDLLMAKGRGKQPSK 813

  Fly    72 SLGQVPPLTEEEQQRHD-----EFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCRECRRRNLAT 131
            ...:..||...:....|     :.:.||..||||..|..:        :..:.||||||......
Frog   814 GRPRTAPLKVGQSVLKDMSKVRKLKQSGEPFLQDGSCINV--------APHLHKCRECRLERYRK 870

  Fly   132 TEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQPDKNTPPTSGYMDIQ 196
            .:.:....|.|.|||:.||||.|...|.|.|.||.:| .:...|.:.:|.|  .:.|..| :|::
Frog   871 FKEQDQDDSTVACRFFHFRRLAFTRKGILRVEGFLSP-QQSDAEAMRLWVP--ISVPADG-IDLE 931

  Fly   197 VCRYILLHAGDQFCYIWHQEAEALSLHQNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTCRKCG 261
            ..:|||.:.|||||.:...|.||:.:.: ....:|||:||:|.||:||||:|||||.||.|||||
Frog   932 TSKYILANVGDQFCQLVMSEKEAMMMVE-PQQKVAWKRAVRGVREMCDVCETTLFNIHWVCRKCG 995

  Fly   262 FGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCSDPSGPQEHVLTELMLTQIIAGDALNVLG 326
            |||||||.:.||.  |.||.:....:  :.:.||.|:.   .|.|....||.||||.|.||..:|
Frog   996 FGVCLDCYRLRKN--RPRREDEIGDE--EVFAWLKCAK---GQPHEPENLMPTQIIPGTALYNIG 1053

  Fly   327 RLLHEVRTLWQVPQVCGCL--------------------------------------------LS 347
            .::|..|..|.:...|.|:                                            |.
Frog  1054 DMVHAARGKWGIKANCPCINRQNKSVLRPAVTNGMSQLPNANNAAADTTTTADEGIENKSDQPLK 1118

  Fly   348 KQAIEDAQSKEVIQDMIKES---------QLKQHTSYSSL-----ASEQKVHQQQR--------- 389
            |:..|:..|.....|:...|         |..:.|..|:|     .:.||..::.:
Frog  1119 KEETENEASSNNDIDIAANSSTDSKNSRPQCPESTPSSALHWLADLAAQKAKEETKDNGTPQSTP 1183

  Fly   390 ---------LDQLHA---------------------TKLEFA-----------------RELGVD 407
                     ||.|:|                     ||.|.:                 .|.|:.
Frog  1184 SKESSPPSGLDPLNANVKTSSPKLFNSLLLGPAASNTKTEGSSLRDLLHSGQGKLSQGNMEAGIP 1248

  Fly   408 YVPGRVW-TKETLGKDP--------ITTAFDNLKHINFLRKGLAGLRRFLPPRTMTFAYSTQLAP 463
            :.|  |: |....||..        |.:..:|.|..:..::..:........:.|....:. ..|
Frog  1249 FPP--VFSTSSAKGKTSLPNFLDHIIASVVENKKTSDAAKRASSSTEALREGKEMVMGLNV-FDP 1310

  Fly   464 GVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPN 528
            ...|.:|||||||.|.|..:.:|..:|:|.||.||||::|.|.:.|..:||.|:||..:|||:..
Frog  1311 HTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVQKKLKSELWKPEAFSVEFGDQDV 1375

  Fly   529 DLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKG 593
            ||:||.|..::.:..:|.||:||..:.|||....|.||:|||||||||:||.:::||||.|||..
Frog  1376 DLVNCRNCAIISDVKVRDFWDGFAVIEKRLRAEDGSPMVLKLKDWPPGEDFRDMMPTRFQDLMDN 1440

  Fly   594 LPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDK--GTTNLHLDISDAVNIMVYV 656
            ||:||||.|.|.||:||.||..||.||||||||||||.....|:  ||||||||:|||||:||||
Frog  1441 LPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYV 1505

  Fly   657 GIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEK 721
            |||. |:: .|.....:.||.|..|.:|:.|.......|||||||:.|:||:|||:||.:|..|:
Frog  1506 GIPV-GES-SQNEEVLRTIEEGDADEVTKKRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGDEQ 1568

  Fly   722 GFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVA 786
            |....|||||||||:||||..||.||:.||||:|..|||.|||||||||||||||.||::|||||
Frog  1569 GQENPPDHDPIHDQSWYLDQVLRKRLYDEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVA 1633

  Fly   787 EDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTILTRAVDERL 844
            |||||||::.||:.||.|||.||::|||||||||:|||||||:||....| :|.:.||
Frog  1634 EDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTL-KAFECRL 1690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JHDM2	NP_001287255.1	JmjC	605..657	CDD:214721	37/53 (70%)
JHDM2	NP_001287255.1	cupin_like	694..789	CDD:304367	66/94 (70%)
kdm3b	XP_002936894.1	PARM	489..>695	CDD:374970
		SPATA3	1112..>1205	CDD:317965	16/92 (17%)
		JmjC	1436..1506	CDD:214721	48/69 (70%)
		cupin_like	1544..1636	CDD:389752	64/91 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	425	1.000	Domainoid score	I610
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	639	1.000	Inparanoid score	I810
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1185631at2759
OrthoFinder	1	1.000	-	-		FOG0001431
OrthoInspector	1	1.000	-	-		otm48962
Panther	1	1.100	-	-	LDO	PTHR12549
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7411
SonicParanoid	1	1.000	-	-		X572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100