DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ras85D and RALB

DIOPT Version :9

Sequence 1:	NP_476699.1	Gene:	Ras85D / 41140	FlyBaseID:	FBgn0003205	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_001356329.1	Gene:	RALB / 5899	HGNCID:	9840	Length:	206	Species:	Homo sapiens

Alignment Length:	192	Identity:	99/192 - (51%)
Similarity:	142/192 - (73%)	Gaps:	6/192 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMR 68
            :|:::||:|||||||||:|.:.:.||::|:||..|||||:||:|||...:|||||||||:|:|:|
Human    15 HKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIR 79

  Fly    69 DQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVK-DAEEVPMVLVGNKCDLAS-WNVNNEQAR 131
            |.|.|:||||||||::...:||.....:||||.||| :.:::|:::||||.||.. ..|..|:||
Human    80 DNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEAR 144

  Fly   132 EVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDK--DNKGRRGRKMNKPNRRFK--CKML 189
            ..|:::|:.|:|||||||..||..|:.|:||||..|  :||.:.|:|.:|..:.||  |.:|
Human   145 SKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ras85D	NP_476699.1	H_N_K_Ras_like	3..164	CDD:133338	87/161 (54%)
RALB	NP_001356329.1	RalA_RalB	15..178	CDD:206710	88/162 (54%)
		Effector region	43..51		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..206		9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820