DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ras85D and KRAS

DIOPT Version :9

Sequence 1:	NP_476699.1	Gene:	Ras85D / 41140	FlyBaseID:	FBgn0003205	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_001356715.1	Gene:	KRAS / 3845	HGNCID:	6407	Length:	189	Species:	Homo sapiens

Alignment Length:	186	Identity:	145/186 - (77%)
Similarity:	162/186 - (87%)	Gaps:	6/186 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65

  Fly    66 AMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLASWNVNNEQA 130
            ||||||||||||||.|||:|:.||||||..||||||||||:|:||||||||||||.|..|:.:||
Human    66 AMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQA 130

  Fly   131 REVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRRGRKMNKPNRRFKC 186
            :::|:.||||:||||||||..|:|||||||||||:      .|.:|::|..:...|
Human   131 QDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQ------YRLKKISKEEKTPGC 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ras85D	NP_476699.1	H_N_K_Ras_like	3..164	CDD:133338	137/160 (86%)
KRAS	NP_001356715.1	H_N_K_Ras_like	3..164	CDD:133338	137/160 (86%)
		Effector region	32..40		7/7 (100%)
		Hypervariable region	166..185		4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1686
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37990
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2788
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	1	1.000	-	-		otm40624
orthoMCL	1	0.900	-	-		OOG6_100217
Panther	1	1.100	-	-	O	PTHR24070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1068
SonicParanoid	1	1.000	-	-		X934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.900