DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ras85D and Eras

DIOPT Version :9

Sequence 1:	NP_476699.1	Gene:	Ras85D / 41140	FlyBaseID:	FBgn0003205	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_853526.1	Gene:	Eras / 353283	MGIID:	2665023	Length:	227	Species:	Mus musculus

Alignment Length:	181	Identity:	78/181 - (43%)
Similarity:	115/181 - (63%)	Gaps:	12/181 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65
            :.|||.|||||.||||||||||:....||.::||||:|||.|:|..|....:|::|||:||:.:.
Mouse    39 LPEYKAVVVGASGVGKSALTIQMTHQCFVKDHDPTIQDSYWKEVARDNGGYILNVLDTSGQDIHR 103

  Fly    66 AMRDQYMRTGEGFLLVFAVNSAKSFEDI----GTYREQIKRVKDAEEVPMVLVGNKCDLASWNVN 126
            |:|||.:.:|:|.|.|||::...|.:.:    .|:....|:       |:|||||||||.:...:
Mouse   104 ALRDQCLASGDGVLGVFALDDPSSLDQLQQIWSTWTPHHKQ-------PLVLVGNKCDLVTTAGD 161

  Fly   127 -NEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRRGRK 176
             :..|..:|.:.|.|.::||||||.||::||..||.||::.::......:|
Mouse   162 AHAAAALLAHKLGAPLVKTSAKTRQGVEEAFALLVHEIQRAQEAVAESSKK 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ras85D	NP_476699.1	H_N_K_Ras_like	3..164	CDD:133338	76/165 (46%)
Eras	NP_853526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		small_GTPase	40..201	CDD:197466	77/167 (46%)
		P-loop_NTPase	42..201	CDD:304359	76/165 (46%)
		Effector region	70..78		5/7 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24070
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880