DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ras85D and krasl

DIOPT Version :9

Sequence 1:	NP_476699.1	Gene:	Ras85D / 41140	FlyBaseID:	FBgn0003205	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	XP_004920180.1	Gene:	krasl / 100485959	XenbaseID:	XB-GENE-22063560	Length:	226	Species:	Xenopus tropicalis

Alignment Length:	228	Identity:	152/228 - (66%)
Similarity:	168/228 - (73%)	Gaps:	41/228 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65

  Fly    66 AMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLASWNVNNEQA 130
            ||||||||||||||.|||:|:.||||||..||||||||||:|:||||||||||||.|..|:.:||
Frog    66 AMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQA 130

  Fly   131 REVAKQYGIPYIETSAKTR---------------------------------------MGVDDAF 156
            :::|:.||||:||||||||                                       |||||||
Frog   131 QDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKMSKEEKTPGCVKVKKCRVMGVDDAF 195

  Fly   157 YTLVREIRKDKDNKGRRGRKMNKPNRRFKCKML 189
            |||||||||.|:...:.|:|  |...:.||.:|
Frog   196 YTLVREIRKHKEKMSKDGKK--KKKSKTKCIIL 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ras85D	NP_476699.1	H_N_K_Ras_like	3..164	CDD:133338	140/199 (70%)
krasl	XP_004920180.1	H_N_K_Ras_like	3..164	CDD:133338	127/160 (79%)
krasl	XP_004920180.1	RAS	16..166	CDD:214541	114/149 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37990
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	1	1.000	-	-		otm47801
Panther	1	1.100	-	-	O	PTHR24070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1068
SonicParanoid	1	1.000	-	-		X934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100