DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rlb1 and Srfbp1

DIOPT Version :9

Sequence 1:NP_477099.1 Gene:Rlb1 / 41139 FlyBaseID:FBgn0014022 Length:463 Species:Drosophila melanogaster
Sequence 2:NP_080316.3 Gene:Srfbp1 / 67222 MGIID:1914472 Length:441 Species:Mus musculus


Alignment Length:529 Identity:120/529 - (22%)
Similarity:189/529 - (35%) Gaps:174/529 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LKFNNLVISNKKVIQKARAQTIAKIVQKL------RKTKEALAKNPDSEKEKIRLRKNTECLAQL 62
            |..||.|:..:|.:::.|...|.|:|:.:      :.|::||.||   ::...||.:....:.:|
Mouse    17 LNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGTEDALLKN---QRRAQRLLEEIHAMKEL 78

  Fly    63 KALKYMDMVRQSLLQEGTNPNAVIANERSTPDELGIAMLRLNKLMHGLVDKFVETLKLST-TDKE 126
            |.    |:|.:|.|.:..|.........||..:..:|.|    ..|.|:.|.::.||.:. ..|:
Mouse    79 KP----DVVTKSALSDDINFEKTCKKPDSTATDRAVARL----AGHPLLKKKIDVLKDAVQAFKD 135

  Fly   127 AKWREEILETSK-----------RRAKIERTEERKRKRKELKEQKAQTKNRLEWLEQNKVVDADV 180
            |:......|:|:           .|:|.:..|.:..:|..::||||:..|               
Mouse   136 ARQSAPAAESSESTSGEGRCKDIARSKDDARESQHPERTVVREQKAKDTN--------------- 185

  Fly   181 NGATAETPTLQVSKVNDQEIPQSFAKTENSPVLKVKKEKTP------------------------ 221
               ||.......||       :..||||.:|    :...||                        
Mouse   186 ---TAAKNAASGSK-------EKLAKTEQAP----RAGTTPGSQGRPSGKGAGVNSEHQGAPAPG 236

  Fly   222 ---------KTP------------AKKERNLQKKQAFDEQINPEITKLSSKKQNLNTIKENNAEP 265
                     |||            :::|.:..:|:.||:.......|.||..::     .::.:.
Mouse   237 DSNQGKASTKTPEDSVCEPANNGVSEEEESEGEKEYFDDSTEERFYKQSSASED-----SDSGDD 296

  Fly   266 QLEGRPKESKPKPF-EKKPAREQKPKPRLERQPSIDEE--EPQLDNNRPTHVVDPFFITESGQPY 327
            ...|:.:.::.|.. ....|:|.||.|::..:.|..|.  :.:.|.:||......|   ||  .:
Mouse   297 FFIGKVRRTRKKESGVHSSAKELKPLPKVPSKTSTLETPWDVRNDKHRPIPEARKF---ES--VF 356

  Fly   328 LSSAVVLSGDNDSEAD-EEQAPPPVKRFRNEDRRSNTYREKPERQPEFKARKPTDDRHPSWLAKQ 391
            ..|   |:|...|..| .||||            .|...:.||.:|..|              ||
Mouse   357 FHS---LAGPKSSRRDPREQAP------------KNKAPDFPENEPPVK--------------KQ 392

  Fly   392 QQKPIIGDFRGKKITFGDDGQAAEIIAPSINQLTATAAPLPTDGMHPSWVAKQKFK---PKIAAF 453
            ..|.....|...|.|.                    .|||     ||||.|.::.|   .|||.|
Mouse   393 FTKSAYRGFESVKQTM--------------------QAPL-----HPSWEASRRRKEQQSKIAVF 432

  Fly   454 QGTKIKFDE 462
            ||.||.||:
Mouse   433 QGKKITFDD 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rlb1NP_477099.1 PTZ00108 <3..345 CDD:240271 86/407 (21%)
BUD22 <389..461 CDD:286199 23/74 (31%)
Srfbp1NP_080316.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 137..342 41/238 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..389 13/46 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..441 19/59 (32%)
BUD22 <411..440 CDD:286199 16/33 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR23325
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
22.060

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