Protein Alignment rump and RBM4

DIOPT Version :10

• Sequence 1: NP_649899.1
• Gene: rump / 41138
• FlyBaseID: FBgn0267790
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_002887.2
• Gene: RBM4 / 5936
• HGNCID: 9901
• Length: 364
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 44/266 - (16%)
• Similarity: 85/266 - (31%)
• Gaps: 111/266 - (41%)

  Fly    58 RVYISNIPYDYRWQDLKDLFRRIVGSIEYVQLFFDESGKARGCGIVEFKDPENVQKALEKMNRYE 122
            :::|.|:|.:...|:::.|              |::.||...|.|::
Human     3 KLFIGNLPREATEQEIRSL--------------FEQYGKVLECDIIK------------------ 35

  Fly   123 VNGRELVVKEDHGEQRDQYGRIVRDGGGGGGGGGGVQGGNGGNNGGGGGGGRDHMDDRDRGFSRR 187
                             .||.:                               |::|:...
Human    36 -----------------NYGFV-------------------------------HIEDKTAA---- 48

  Fly   188 DDDRLSGRNNFNMMSNDYNNSSNYNLYGLSASFLESLGISGPLHNKVFVANLDYKVDNKKLKQVF 252
             :|.:             .|..:|.|:|::.: :|:.........|:.|.|:.....||:|:..|
Human    49 -EDAI-------------RNLHHYKLHGVNIN-VEASKNKSKTSTKLHVGNISPTCTNKELRAKF 98

  Fly   253 KLAGKVQSVDLSLDKEGNSRGFAVIEYDHPVEAVQAISMLDRQMLFDRRMTVRLDRIPDKNEGIK 317
            :..|.|...|:..|       :|.:..:...:||:||..||......:||.|:|     ....::
Human    99 EEYGPVIECDIVKD-------YAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQL-----STSRLR 151

  Fly   318 LPEGLG 323
            ...|:|
Human   152 TAPGMG 157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rump	NP_649899.1	PABP-1234	48..435	CDD:130689	44/266 (17%)
		RRM1_hnRNPM_like	58..133	CDD:409819	10/74 (14%)
		RRM2_hnRNPM_like	234..307	CDD:409820	20/72 (28%)
		RRM_SF	565..629	CDD:473069
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	19/163 (12%)
		RRM2_RBM4	78..144	CDD:410019	20/72 (28%)
		PTZ00368	<145..>181	CDD:173561	3/18 (17%)
		ZnF_C2HC	161..176	CDD:197667
		Interaction with TNPO3. /evidence=ECO:0000269|PubMed:12628928	196..364