DRSC/TRiP Functional Genomics Resources

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Protein Alignment rump and HNRNPM

DIOPT Version :9

Sequence 1:NP_649899.1 Gene:rump / 41138 FlyBaseID:FBgn0267790 Length:632 Species:Drosophila melanogaster
Sequence 2:NP_005959.2 Gene:HNRNPM / 4670 HGNCID:5046 Length:730 Species:Homo sapiens


Alignment Length:783 Identity:219/783 - (27%)
Similarity:327/783 - (41%) Gaps:219/783 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 MDASNSVESREKERDRRGRGARGSRFTDADGNGNGA-GSQGGGV-AARDRSRERRNC-------- 57
            ::|:..|.:.|.:.:... ||.|.      .:|||| |.:|.|. .|::..|:.:|.        
Human     5 VEAAAEVAATEIKMEEES-GAPGV------PSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFE 62

  Fly    58 ---------RVYISNIPYDYRWQDLKDLFRRIVGSIEYVQLFFDESGKARGCGIVEFKDPENVQK 113
                     |.:|:|||:|.:||.||||.:..||.:.||:|..|..||:|||.:||||..|:::|
Human    63 PYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKK 127

  Fly   114 ALEKMNRYEVNGRELVVKEDHGEQRDQYGRIVRDGGGGGGGGGGVQGGNGGNNGGGGGGGRDHMD 178
            |.|.:|::.::||.|.||||            .||.........|....||...|.||.|...:.
Human   128 AAEVLNKHSLSGRPLKVKED------------PDGEHARRAMQKVMATTGGMGMGPGGPGMITIP 180

  Fly   179 DRDRGFSRRDDDRLSGRNNFNMMSNDYNNSSNYNLYGLSASFLESLGISGPLHNKVFVANLDYKV 243
            .                   ::::|.  |..|..::.|.|         |.|.:.||||||||||
Human   181 P-------------------SILNNP--NIPNEIIHALQA---------GRLGSTVFVANLDYKV 215

  Fly   244 DNKKLKQVFKLAGKVQSVDLSLDKEGNSRGFAVIEYDHPVEAVQAISMLDRQMLFDRRMTVRLDR 308
            ..||||:||.:||.|...|:..||:|.|||...:.::..:||||||||.:.|:||||.|.|::|.
Human   216 GWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDE 280

  Fly   309 ---------IPDKNEGIKLPEGLGGVGIGLGPNGEPLRDVAH--------NL-PNGGQSQGQLLG 355
                     .|::.:  :||.||||:|:||||.|:|: |..|        |: |.|...:|...|
Human   281 RALPKGDFFPPERPQ--QLPHGLGGIGMGLGPGGQPI-DANHLNKGIGMGNIGPAGMGMEGIGFG 342

  Fly   356 NAQQG----------SQLGSVGSQPNSSAVSNATTNLLNNLTGVMFGNHAAVQ-----PSPVAPV 405
            ..:.|          ..:|..||..|...::...:|.|..      |...|.|     ...|..:
Human   343 INKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKR------GEIIAKQGGGGGGGSVPGI 401

  Fly   406 QK--PSLGNNTGSG--------GLNLNNLNPSI--LAAVVGNLGN-----QGGNLSNPL----LS 449
            ::  |.:....|:|        |..::.:...|  :..|:..:|:     .|.....||    ::
Human   402 ERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMA 466

  Fly   450 SSLSNLGLNLGNSGND---------------------------------DNLPPS--NVGLS-NN 478
            ||:..:|..:...|:.                                 :.:.|:  .:||| ..
Human   467 SSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMER 531

  Fly   479 YSSGGTGGG--------NSYSSG------NNYSGGG------------GSSNLGYNAYSSSG--- 514
            ....|.|.|        :..::|      ||....|            |...:|.|:....|   
Human   532 MVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAM 596

  Fly   515 ----GMG--------GGNGGVGVD-GNDYNTGNPLDVYGGGSNVGNSNVGSANAVGASRKSDTII 566
                |.|        ||.||...| ..:...||     .|||..|:......:|.|.:||:..|.
Human   597 GPALGAGIERMGLAMGGGGGASFDRAIEMERGN-----FGGSFAGSFGGAGGHAPGVARKACQIF 656

  Fly   567 IKNVPITCTWQTLRDKFREIGDVKFAEI-----RGNDVGVVRFFKERDAELAIALMDGSRLDGRN 626
            ::|:|...||:.|:|||.|.|.|.:|:|     :....|||:|.....||.|..:|:|.:|.||.
Human   657 VRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGRE 721

  Fly   627 IKV 629
            |.|
Human   722 IDV 724

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rumpNP_649899.1 PABP-1234 48..435 CDD:130689 137/448 (31%)
RRM1_hnRNPM_like 58..133 CDD:240831 37/74 (50%)
RRM2_hnRNPM_like 234..307 CDD:240832 41/72 (57%)
RRM <543..>631 CDD:223796 34/92 (37%)
RRM_SF 565..630 CDD:302621 28/70 (40%)
HNRNPMNP_005959.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 16/63 (25%)
HnRNP_M 41..70 CDD:402915 3/28 (11%)
RRM1_hnRNPM 72..147 CDD:410058 37/74 (50%)
RRM2_hnRNPM 204..279 CDD:410060 41/74 (55%)
27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV] 400..608 31/207 (15%)
antiphage_ZorA_3 <414..553 CDD:411477 19/138 (14%)
RRM3_hnRNPM 654..730 CDD:410062 28/71 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154904
Domainoid 1 1.000 99 1.000 Domainoid score I7081
eggNOG 1 0.900 - - E1_COG0724
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 251 1.000 Inparanoid score I3227
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48675
OrthoDB 1 1.010 - - D1174365at2759
OrthoFinder 1 1.000 - - FOG0003017
OrthoInspector 1 1.000 - - otm41074
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR23003
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4422
SonicParanoid 1 1.000 - - X1365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.990

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