DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rump and cip2

DIOPT Version :9

Sequence 1:	NP_649899.1	Gene:	rump / 41138	FlyBaseID:	FBgn0267790	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_592895.1	Gene:	cip2 / 2543139	PomBaseID:	SPAC12G12.03	Length:	576	Species:	Schizosaccharomyces pombe

Alignment Length:	584	Identity:	112/584 - (19%)
Similarity:	178/584 - (30%)	Gaps:	241/584 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 EVNG------RELVVKEDHGEQRDQYGR---IVRDG--GGGGGGGGGVQGGNGGNNGGGGGGG-- 173
            |:||      |.|.:....|...::|||   ...|.  ...|.||.|:...|..::|.|.|..
pombe    52 ELNGAQDEEMRGLNIPGGSGYLENRYGRDKFTFSDAAVNSAGMGGSGIFSHNNADDGLGDGSSTV 116

  Fly   174 -----RDHMDD-------------RDR------------GFSRRDDDRL-----SGRNNFNMMS- 202
                 :..:|.             |.|            |.|.|....|     ||....:::|
pombe   117 LPSSLKQMLDPEISTANNPSAKPRRTRLQTAWKEATNSAGLSLRSASALDVLKNSGPATTSLLSS 181

  Fly   203 --------NDYNNSSNYNLYGLSASFLESLGISG-------------PLHNKVFVANLDYKVDNK 246
                    |.:|..|:.::...::|...|.|:|.             .:...:.:.|:.:.:..:
pombe   182 TTYPFDSLNAFNEPSHSHVPNSASSTALSRGMSNSVTLTAPPEPDEETIPTAIVIKNIPFSLKKE 246

  Fly   247 KLKQVFKLAGKVQSVDLSLD-----------KEGNSRGFAVIEYDHPVEAVQAISMLDRQMLFDR 300
            .|.:||          .:||           ..|..||.|...:..|.||...:.:|:...:..|
pombe   247 VLFKVF----------TALDIPRPYAFNYHFDNGVFRGLAFANFHSPEEAKTVVQVLNGYEITGR 301

  Fly   301 RMTV------------RLDR-------IPDKNEGIKLPEGLGGVGIGLGPNGEPLRDVAHNLPNG 346
            |:.|            |::|       :.::...:|.|..:..:|.|
pombe   302 RLRVEWKRQLPPAERERVERGKQEKRAVEERKNQLKSPFSVANIGAG------------------ 348

  Fly   347 GQSQGQLLGNAQQGSQLGSVGSQPNSSAVSNATTNLL------NNLTGVMFGNHAAVQPSPVAPV 405
                               :....|..|:.|..:::|      :|...::|.:....:...||.:
pombe   349 -------------------IDFDLNDPAILNVYSHILLFYYRSDNTNDLVFDSSTTQEERRVAAL 394

  Fly   406 QKPSLGNN---TGSG----------------------------GLNLNNLNPSILAAVVGNLGNQ 439
            ....|..|   ||.|                            ..|.:.||||.|.|
pombe   395 LASRLNLNHSVTGDGEAKQVVITMPSTHFTPANNSSANHSPLMAPNASTLNPSSLGA-------- 451

  Fly   440 GGNLSNPLLSSSLSNLGLNLGNSGNDDNLPPSNVGLSNNYSS-----------------GGTGGG 487
             .|||.|.|::.||:.||       .||...|:.|||:|:||                 .|....
pombe   452 -SNLSQPSLANHLSSSGL-------FDNGLFSSGGLSSNFSSLRRPAPSMHLADSIRSLRGLNDS 508

  Fly   488 NSYSS-----------GNNYSGGGGSSNLGYNAYSSSGGMGGGNGGVGVDGNDY-------NTG 533
            .::|.           ...::....||.|..||.:||..:.|.      ..|||       |||
pombe   509 KAFSDIRSMPATPLELATPFANLNVSSPLDRNATNSSNTLNGS------AMNDYFASLTPSNTG 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rump	NP_649899.1	PABP-1234	48..435	CDD:130689	78/449 (17%)
		RRM1_hnRNPM_like	58..133	CDD:240831	5/16 (31%)
		RRM2_hnRNPM_like	234..307	CDD:240832	18/95 (19%)
		RRM	<543..>631	CDD:223796
		RRM_SF	565..630	CDD:302621
cip2	NP_592895.1	RRM	114..>338	CDD:223796	36/233 (15%)
		RRM_PIN4_like	231..309	CDD:240699	17/87 (20%)
		R3H_RRM	358..418	CDD:100068	11/59 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23003
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000