DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoL and GEM1

DIOPT Version :9

Sequence 1:	NP_001247003.1	Gene:	RhoL / 41136	FlyBaseID:	FBgn0014380	Length:	214	Species:	Drosophila melanogaster
Sequence 2:	NP_009351.1	Gene:	GEM1 / 851249	SGDID:	S000000046	Length:	662	Species:	Saccharomyces cerevisiae

Alignment Length:	194	Identity:	50/194 - (25%)
Similarity:	84/194 - (43%)	Gaps:	46/194 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LKITIVGDGMVGKTCMLITYTRNEFPEEYIPTVFDNHACNIAVDDRDY---------NLTLWDTA 91
            :::.|.||..|||:.::::.|:.||    |||:.| ....|:: .||:         |..|.||:
Yeast     6 IRVVICGDEGVGKSSLIVSLTKAEF----IPTIQD-VLPPISI-PRDFSSSPTYSPKNTVLIDTS 64

  Fly    92 GQE----DYERLRPLSYPSTNCFLLCYSISSRTSFENVKSKWWPEIRHFSAHVPVVLVGTKLD-- 150
            ..:    |:|      ..|.:...|.|  ....|:::|...|.|..|....::||:|...|.|
Yeast    65 DSDLIALDHE------LKSADVIWLVY--CDHESYDHVSLFWLPHFRSLGLNIPVILCKNKCDSI 121

  Fly   151 --------LRIPNSEKFVTTQ-EGKKM------RKEIHAFNLVECSAKKKQNLQQVFEEAVRAV 199
                    :...||:..:.|: |.::.      .|||.  ..::.|||.:.:|.|.|....||:
Yeast   122 SNVNANAMVVSENSDDDIDTKVEDEEFIPILMEFKEID--TCIKTSAKTQFDLNQAFYLCQRAI 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoL	NP_001247003.1	Rho	36..198	CDD:206641	48/191 (25%)
RhoL	NP_001247003.1	RHO	38..202	CDD:197554	50/192 (26%)
GEM1	NP_009351.1	P-loop_NTPase	6..186	CDD:422963	50/194 (26%)
		EF_assoc_2	236..329	CDD:400591
		EF_assoc_1	369..434	CDD:400590
		Miro2	445..624	CDD:206679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1464
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950