DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoL and RAC2

DIOPT Version :9

Sequence 1:	NP_001247003.1	Gene:	RhoL / 41136	FlyBaseID:	FBgn0014380	Length:	214	Species:	Drosophila melanogaster
Sequence 2:	NP_002863.1	Gene:	RAC2 / 5880	HGNCID:	9802	Length:	192	Species:	Homo sapiens

Alignment Length:	189	Identity:	98/189 - (51%)
Similarity:	132/189 - (69%)	Gaps:	10/189 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LKITIVGDGMVGKTCMLITYTRNEFPEEYIPTVFDNHACNIAVDDRDYNLTLWDTAGQEDYERLR 100
            :|..:||||.|||||:||:||.|.||.|||||||||::.|:.||.:..||.||||||||||:|||
Human     4 IKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLR 68

  Fly   101 PLSYPSTNCFLLCYSISSRTSFENVKSKWWPEIRHFSAHVPVVLVGTKLDLRIPNS--EKF---- 159
            |||||.|:.||:|:|:.|..|:|||::||:||:||.....|::|||||||||....  ||.
Human    69 PLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKK 133

  Fly   160 ---VTTQEGKKMRKEIHAFNLVECSAKKKQNLQQVFEEAVRAVE-RKPKTTSKQSCKIL 214
               :|..:|..:.|||.:...:||||..::.|:.||:||:|||. .:|....|::|.:|
Human   134 LAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRACSLL 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoL	NP_001247003.1	Rho	36..198	CDD:206641	91/170 (54%)
RhoL	NP_001247003.1	RHO	38..202	CDD:197554	93/173 (54%)
RAC2	NP_002863.1	Rac1_like	3..176	CDD:206663	92/171 (54%)
RAC2	NP_002863.1	Effector region. /evidence=ECO:0000255	32..40		7/7 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810