DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoL and RHOT1

DIOPT Version :9

Sequence 1:	NP_001247003.1	Gene:	RhoL / 41136	FlyBaseID:	FBgn0014380	Length:	214	Species:	Drosophila melanogaster
Sequence 2:	NP_001028740.1	Gene:	RHOT1 / 55288	HGNCID:	21168	Length:	691	Species:	Homo sapiens

Alignment Length:	170	Identity:	45/170 - (26%)
Similarity:	87/170 - (51%)	Gaps:	10/170 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RPLKITIVGDGMVGKTCMLITYTRNEFPEEYIPTVFD-NHACNIAVDDRDYNLTLWDTAGQEDYE 97
            :.::|.:||:..||||.::::....|||||..|...: ....::..:....::..:..|.|.|.:
Human     3 KDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQ 67

  Fly    98 RLRPLSYPSTNCFLLCYSISSRTSFENVKSKWWPEIRHFS---AHVPVVLVGTKLDLRIPNSEKF 159
            ..:.:|..:..|  :.|:::::.|.:.|.|:|.|.|...:   :.:|::|||.|.||...:|.:.
Human    68 LHQEISQANVIC--IVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMET 130

  Fly   160 VTTQEGKKMRKEIHAFNLVECSAKKKQNLQQVFEEAVRAV 199
            :.    ..|.:.......||||||..:|:.::|..|.:||
Human   131 IL----PIMNQYTEIETCVECSAKNLKNISELFYYAQKAV 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoL	NP_001247003.1	Rho	36..198	CDD:206641	43/165 (26%)
RhoL	NP_001247003.1	RHO	38..202	CDD:197554	45/166 (27%)
RHOT1	NP_001028740.1	Miro1	3..169	CDD:206680	45/170 (26%)
		RHO	7..169	CDD:197554	45/166 (27%)
		EF_assoc_2	221..301	CDD:285547
		EF_assoc_1	341..409	CDD:285546
		Miro2	415..580	CDD:206679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1464
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950