DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoL and RHOH

DIOPT Version :9

Sequence 1:	NP_001247003.1	Gene:	RhoL / 41136	FlyBaseID:	FBgn0014380	Length:	214	Species:	Drosophila melanogaster
Sequence 2:	NP_001265288.1	Gene:	RHOH / 399	HGNCID:	686	Length:	191	Species:	Homo sapiens

Alignment Length:	186	Identity:	72/186 - (38%)
Similarity:	109/186 - (58%)	Gaps:	8/186 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LKITIVGDGMVGKTCMLITYTRNEFPEEYIPTVFDNHACNIAVDDRDYNLTLWDTAGQEDYERLR 100
            :|..:|||..||||.:|:.:|...|||.|.|||::|...::.:|....:|.||||||.:.:..:|
Human     5 IKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIR 69

  Fly   101 PLSYPSTNCFLLCYSISSRTSFENVKSKWWPEIRHFSAHVPVVLVGTKLDLRI--PNSEKFVTTQ 163
            ||||...:..|:|||:::..||.|:|:||..|||......||::|.|:.|.|.  |:....|...
Human    70 PLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQREMGPHRASCVNAM 134

  Fly   164 EGKKMRKEIHAFNLVECSAKKKQNLQQVFEEAVRAVERKPKTTSKQ------SCKI 213
            ||||:.:::.|...:||||...:.:|||||.|||....:.:..:::      .|||
Human   135 EGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRLFSINECKI 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoL	NP_001247003.1	Rho	36..198	CDD:206641	68/163 (42%)
RhoL	NP_001247003.1	RHO	38..202	CDD:197554	68/165 (41%)
RHOH	NP_001265288.1	Rho	5..169	CDD:206641	68/163 (42%)
		Effector region. /evidence=ECO:0000250	33..41		4/7 (57%)
		Interaction with ZAP70. /evidence=ECO:0000250	73..86		5/12 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910