DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and alpi.2

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001020359.1	Gene:	alpi.2 / 574009	ZFINID:	ZDB-GENE-050626-142	Length:	521	Species:	Danio rerio

Alignment Length:	501	Identity:	212/501 - (42%)
Similarity:	284/501 - (56%)	Gaps:	37/501 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG---- 116
            |..|..||:...:|...|..:|...|  .:..||..|:|::||:||||.|.|:||.||..|
Zfish    22 FSVVPEEEKNPNFWYVKAKDSLHASL--SMTFNTHRAKNLILFLGDGMGISTVTAARVLKGQMNK 84

  Fly   117 --GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQ 179
              |||...|.:.|||:.|||||..:.|:.|||.||||||.||||||||:|:|||.|.:.|  .:.
Zfish    85 KTGEESVLAMDTFPYLALSKTYNVDQQMPDSAATATAYLCGVKANYGTLGLSAAAQREVC--SSV 147

  Fly   180 AAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGD---NGDPDLCPD 241
            ..:.|.||...|:..|.:.|:|:|..|.|||||..|:|...|.|.:|.|:..:   .|    |.|
Zfish   148 KGNEVKSILHQAKMAGKSVGIVSTARVQHASPAASYSHTPERGWYSDKELTSEAVAGG----CQD 208

  Fly   242 AAAQLINSPVGQKLNVIMGGGRENFLPKGVTDS--SGAPGRRLDGRNLIDEWKNQHTNSAQYVEN 304
            .|.|||.:   ..:|||:||||:...|:..||.  |...|.|.|.|||:|||.....| ||||.|
Zfish   209 IAVQLITN---TDINVILGGGRQYMFPRETTDPEYSTVTGSRKDKRNLVDEWLKNRKN-AQYVWN 269

  Fly   305 RREL--LNLSNHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFLFVEG 367
            :::.  :| .:.|..::|||.|....|.|:..|...|:|.|||:.|::||.:..  .|::|||||
Zfish   270 KQQFDAVN-EDKTDYLMGLFEPKDTRYELERDPKMDPSLTEMVEKAIKILRKNP--NGFYLFVEG 331

  Fly   368 GRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFGI 432
            ||||||||...|..|:.|..|||.::..|...||..|||.||::||||..|..|||.|.|.:.|:
Zfish   332 GRIDHGHHAGQAKYALTEAVEFDNSIERAGQLTSELDTLSVVTADHSHVFSFGGYSYRGNPVLGV 396

  Fly   433 NDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESETHGGD 497
            :..: ..|...:....|.|||||.   :..|   .|.::........|::..:.|||:|||||.:
Zfish   397 SYAK-GEDGKSFTNALYGNGPGYQ---ITNG---TRPDVNESVSGRDDYLQQAAVPLDSETHGSE 454

  Fly   498 DVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMCV--DGGV 541
            |||:||.||.|.||.||.||.:||||:.:|:|:...:.|.  |.||
Zfish   455 DVAIFAKGPMAHLFHGVQEQSYIPHAMAFAACIEPYSDCQLHDSGV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	200/465 (43%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	196/449 (44%)
alpi.2	NP_001020359.1	Alk_phosphatase	56..487	CDD:278666	197/450 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593244
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910