DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and AgaP_AGAP011305

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_001688180.1	Gene:	AgaP_AGAP011305 / 5667804	VectorBaseID:	AGAP011305	Length:	571	Species:	Anopheles gambiae

Alignment Length:	561	Identity:	236/561 - (42%)
Similarity:	320/561 - (57%)	Gaps:	68/561 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLQLFFFLGLSV--LVSGGESSHDAERRMHP-----VFSLMGTGSNPIGGGRYKRAMPQIVFDA 58
            :|..:|..:.||.  |.:.|||:.....:.||     ||                :::|  ::|
Mosquito     5 VRCAVFLLIALSATSLSARGESTPREPGQQHPRSDRRVF----------------QSVP--IYD- 50

  Fly    59 VRSEERYAEYWQGLAAQTLDQQL-----ESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLGGE 118
              .:|..:|||:.:|.::|..|.     |.|       |:||:.||||||.:.|:.|.|:|||.|
Mosquito    51 --KQEEESEYWRTVAQRSLQHQAAHPRSERK-------AKNVVYFIGDGMGLSTVAAARMYLGNE 106

  Fly   119 EKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHH 183
            ....:||:|||.||:||||.|.|||||||||||||.|||.|||.:.|:|:|:...|:....|. .
Mosquito   107 NMYLSFEKFPYFGLAKTYCVNRQVADSACTATAYLSGVKINYGMLNVAASVKRSSCEYDRNAT-E 170

  Fly   184 VSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCP-------- 240
            ...:..|||:.|.|||:||||.:|||:|.|.||..|:|:||:|.||..|      ||
Mosquito   171 FKGLLEWAQQAGKATGIVTTTRITHATPGGTYASSADRDWEDDTEVNND------CPTTRQEDKP 229

  Fly   241 -DAAAQLINSPVGQKLNVIMGGGRENFLPKGVTDSSGAPGRRLDGRNLIDEWKNQHTN--SAQYV 302
             |.|.||:...||:.|.|.:|.||.:|:|..|.|..|..|:|.||.|||:.||..|.:  .|:||
Mosquito   230 VDIATQLVYGSVGKNLKVALGCGRRHFIPADVKDEDGKAGKRSDGVNLIEAWKEVHADMGEARYV 294

  Fly   303 ENRRELLNL--SNHTSRVLGLFAPYHMAYHLDASPAE----QPTLEEMVQSAMEILERQSAGRGY 361
            .:::.||..  |.....:||||...|..|:|:....:    :|.|.:||.:|:.:||  .:.:||
Mosquito   295 SDKKSLLEAAKSKKLDYLLGLFDSSHCLYNLEIDDQKLGDVKPKLTDMVDAALSMLE--DSEQGY 357

  Fly   362 FLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRK 426
            .||||||.||..||......:::||.||.||:..||:.||.:|||||||||||||:...||.:|.
Mosquito   358 VLFVEGGLIDTAHHSNRPRLSLEETKEFHKAIELARTRTSEEDTLIVVSSDHSHTLMYNGYPTRG 422

  Fly   427 NDIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLES 491
            |||.||.|.. ..|.|||.|||||||.|:...| .:|...:|.::...:..:....:.:||||.|
Mosquito   423 NDILGIGDIS-DKDGLPYTTLSYANGEGFYQTY-ADGNPSKRLDVTGYDFSDYRQRYLATVPLSS 485

  Fly   492 ETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSD 532
            |||||:||.|:||||.|.||.|..||:.||..:.||:.:.|
Mosquito   486 ETHGGEDVGVYASGPGAHLFGGSTEQNVIPLLIAYAANIGD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	215/474 (45%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	211/453 (47%)
AgaP_AGAP011305	XP_001688180.1	PhoA	61..527	CDD:224699	218/484 (45%)
AgaP_AGAP011305	XP_001688180.1	ALP_like	81..525	CDD:304875	211/454 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	5	4.930