DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and alpi.1

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_002937387.2	Gene:	alpi.1 / 548375	XenbaseID:	XB-GENE-854726	Length:	529	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	206/498 - (41%)
Similarity:	299/498 - (60%)	Gaps:	40/498 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG---- 116
            :..:.:||...|:|.......:::.|  ||:.....|:|::||:||||.:||:||.|:..|
Frog    21 YATIPAEESQPEFWNNKMISRINEAL--KLKPIQHRAKNLILFLGDGMGVPTVTATRILSGQMKR 83

  Fly   117 --GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQ 179
              |||.:.|.::|||..|||||..:.||.|||.|||||..||||||||:||:|||:..:|  ...
Frog    84 MLGEENELAMDKFPYTALSKTYNVDRQVPDSAGTATAYNCGVKANYGTVGVTAAVKRSNC--SNM 146

  Fly   180 AAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDN---GDPDLCPD 241
            ..:.|.|:...|:..|.:.|:||||.|.||||:|.|||:.:|:|.:||.:..|.   |    |.|
Frog   147 KGNEVESVLKKAKAAGKSVGIVTTTRVQHASPSGTYAHIPDRDWYSDANMPADAVNFG----CKD 207

  Fly   242 AAAQLINSPVGQKLNVIMGGGRENFLPKGVTD-----SSGAPGRRLDGRNLIDEW--KNQHTNSA 299
            .|.|||::   ..::||:||||:...|.|.:|     .....|.|.|||||||||  ||:   .|
Frog   208 IAQQLISN---VDIDVILGGGRKYMTPVGTSDPEYPADKKQNGIRKDGRNLIDEWLRKNK---GA 266

  Fly   300 QYVENRRELLNLSNHTSR-VLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFL 363
            |||.|:.:|..::..|:: |:|||.|..|.|.|:.:....|::.|:.:.|:.:|:|..  .|::|
Frog   267 QYVWNKEQLDKINVSTAKHVMGLFEPADMKYELNRNITTDPSIVELTEIAIRLLQRNP--NGFYL 329

  Fly   364 FVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKND 428
            |||||||||||||..|.:|:.|...||:|::.|...|:..|||.||::||||..:..||:.|.:.
Frog   330 FVEGGRIDHGHHDGQAKQALTEGVMFDRAIKIAGQLTNEMDTLTVVTADHSHVFTFGGYTYRGSS 394

  Fly   429 IFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESET 493
            |||:.. :.|.|:..|.::.|.||||:  |...:|    |.|:.:...:...::..:.|||:|||
Frog   395 IFGLAP-KKAFDNKSYTSILYGNGPGF--NLTGQG----RPNVDSNISEEVGYLQQAAVPLDSET 452

  Fly   494 HGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            |||:|||:|:.||.:.||.||.||.::.|.:.||:||.....|
Frog   453 HGGEDVAIFSKGPMSHLFHGVQEQTYVAHVMAYAACLPPYKDC 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	197/469 (42%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	195/453 (43%)
alpi.1	XP_002937387.2	Alk_phosphatase	55..489	CDD:333956	196/454 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	372	1.000	Domainoid score	I883
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	382	1.000	Inparanoid score	I2005
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm9329
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080