DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and Alpg

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_038940610.1	Gene:	Alpg / 367308	RGDID:	1565100	Length:	533	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	210/500 - (42%)
Similarity:	288/500 - (57%)	Gaps:	36/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG- 116
            |:.|..:..||....:|...|.:.||  :..||:.....|:|:::|:||||.:||:||.|:..|
  Rat    17 QLSFGVIPVEEENPAFWNQKAKEALD--VAKKLKPIRTSAKNLIIFLGDGMGVPTVTATRILKGQ 79

  Fly   117 -----GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQA 176
                 |.|...|.:.||:..|||||..:.||.|||.||||||.||||||.|||||||.:|..|
  Rat    80 LGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQC-- 142

  Fly   177 QAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVG---DNGDPDL 238
            .:...:.|.|:...|:|.|.:.|:||||||.||||||.|||..|.:|.:||.:..   ..|
  Rat   143 NSTFGNEVFSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNCDWYSDAHMATAALQEG---- 203

  Fly   239 CPDAAAQLINSPVGQKLNVIMGGGRENFLPKGVTD-----SSGAPGRRLDGRNLIDEWKNQHTNS 298
            |.|.|.|||::   ..::||:||||:...|||..|     :....|.||||:||:.:|..:| ..
  Rat   204 CKDIAMQLISN---MDIDVILGGGRKFMFPKGTPDPEYSGNRAQSGTRLDGQNLVQKWLAKH-QG 264

  Fly   299 AQYVENRRELLNLSNHT--SRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGY 361
            |:||.||.||:..|..:  :.::|||.|..|.|.:...|.:.|:|.||.:.|:.:|.|..  :|:
  Rat   265 ARYVWNRTELIQASQDSAVTHLMGLFEPNDMKYDIYRDPTQDPSLAEMTEVAVHLLSRNP--KGF 327

  Fly   362 FLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRK 426
            :||||||.||||||:::|.||:.|...||.||..|...||..||:|:|::||||..|..||..|.
  Rat   328 YLFVEGGHIDHGHHESIAYRALTEAVMFDSAVDKANKLTSEKDTMILVTADHSHVFSFGGYVPRG 392

  Fly   427 NDIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLES 491
            ..|||:.....|.|..|:.::.|.|||||.   |.:|   .|.::.....::..:...:.|||.|
  Rat   393 TSIFGLGASFNALDGRPFTSILYGNGPGYK---LEKG---TRPDVTDKESRDPKYRQQAAVPLSS 451

  Fly   492 ETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            |||.|:|||:||.||.|.|..||.||::|.|.:.:|.||.....|
  Rat   452 ETHSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDC 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	201/468 (43%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	196/452 (43%)
Alpg	XP_038940610.1	Alk_phosphatase	54..490	CDD:395188	197/453 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351471
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860