DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and Alp12

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001188848.1	Gene:	Alp12 / 35218	FlyBaseID:	FBgn0032779	Length:	596	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	200/544 - (36%)
Similarity:	283/544 - (52%)	Gaps:	73/544 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SNPIGGGRYKRA---MPQIVFDAVR------------------SEERYAEYW------------- 69
            |||:...::.|:   :..:||.|:.                  .:.....||
  Fly    50 SNPVQHTKWFRSRLFLISVVFSALLITAMCIGFVVHYGMSGDVGDMETVSYWPVDLPKEQKEWYD 114

  Fly    70 QGLAAQTLDQQLESKL--RLNTQLARNVMLFIGDGMSIPTITAGRVYLGGEEKQFAFEQFPYVGL 132
            ||:      .:|:..:  :.|.:.|:||:||:||||...|:||.|:....||....:||||.:||
  Fly   115 QGI------DELQKAVSRQFNRRRAKNVILFVGDGMGPNTVTAARILGVKEEGLLRWEQFPDMGL 173

  Fly   133 SKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMA 197
            .|||||:.||.||..||||..||||.||.|.||.|.|...:|.|..:..|||.:|..|||..||.
  Fly   174 LKTYCADKQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKEDHHVQTILKWAQVDGMR 238

  Fly   198 TGLVTTTSVTHASPAGVYAHLANRNWEND----AEVVGDNGDPDLCPDAAAQLINSPVGQKLNVI 258
            ||.||||.||||:||.:|||:.:|.||.:    ||..|..     |.|.|.|||..|.||.:|||
  Fly   239 TGFVTTTRVTHATPAALYAHVPDRRWECESGMPAEAQGQG-----CMDIARQLIEQPTGQSINVI 298

  Fly   259 MGGGRENFLPKGVTDSSGAP-----GRRLDGRNLIDEWKNQHTN---SAQYVENRRELLNLSNH- 314
            |||||: .|...||.|:..|     |:..|||:||.:|:.:..:   |...|:|.|||.||:..
  Fly   299 MGGGRQ-MLVSDVTGSAADPLDTWAGQSKDGRDLIRDWRLKKADEGVSHAVVQNNRELWNLNGQD 362

  Fly   315 TSRVLGLFAPYHMAY--HLDASPAEQPTLEEMVQSAMEILERQSAGRGYFLFVEGGRIDHGHHDT 377
            ...|||:||..|:.|  ..|.|.|..|:|..|...|:|:|  .::.:|:.|.||.|.||..||..
  Fly   363 VDYVLGIFANGHLMYDHERDRSDAGMPSLSNMTLKALEVL--GNSDKGFLLVVEAGLIDQAHHRG 425

  Fly   378 LALRAIDETAEFDKAVR----FARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFGINDGQLA 438
            .|.:|:.|..|.:.||.    |.:|....|:||::|::||||::::.|:..|.:.|.|: .|...
  Fly   426 NARKALSEVLELNAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPDRGSSILGL-AGNSK 489

  Fly   439 ADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESETHGGDDVAVFA 503
            .:..||.||:|  |..| ..:..:.....||:..|.::...::...:.:..:...|||.||.:.|
  Fly   490 TEGTPYTTLTY--GTSY-QGFQVDPQTQSRKDPTADDITAWEYTQQAAINTDENLHGGSDVTIHA 551

  Fly   504 SGPYAQLFTGVFEQHFIPHALGYA 527
            .|..:.||.||.||.::.||:.||
  Fly   552 DGAMSYLFHGVHEQSYVAHAISYA 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	187/473 (40%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	186/454 (41%)
Alp12	NP_001188848.1	ALP_like	134..579	CDD:304875	186/454 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466667
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.800