DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phu and ALPG

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_112603.2	Gene:	ALPG / 251	HGNCID:	441	Length:	532	Species:	Homo sapiens

Alignment Length:	499	Identity:	215/499 - (43%)
Similarity:	288/499 - (57%)	Gaps:	35/499 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG- 116
            |:....:..||...::|...||:.|.  ...||:.....|:|:::|:||||.:.|:||.|:..|
Human    15 QLSLGIIPVEEENPDFWNRQAAEALG--AAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQ 77

  Fly   117 -----GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQA 176
                 |.|...|.::||||.|||||..:..|.||..||||||.|||.|:.|||:|||.:|..|
Human    78 KKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQC-- 140

  Fly   177 QAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPD 241
            .....:.|.|:...|:|.|.:.|:||||.|.||||||.|||..||||.:||:|.. :...:.|.|
Human   141 NTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPA-SARQEGCQD 204

  Fly   242 AAAQLINSPVGQKLNVIMGGGRENFLPKGVTD-------SSGAPGRRLDGRNLIDEWKNQHTNSA 299
            .|.|||::   ..::||:||||:...|.|..|       |.|  |.||||:||:.||..:| ..|
Human   205 IATQLISN---MDIDVILGGGRKYMFPMGTPDPEYPDDYSQG--GTRLDGKNLVQEWLAKH-QGA 263

  Fly   300 QYVENRRELL--NLSNHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYF 362
            :||.||.|||  :|....:.::|||.|..|.|.:.......|:|.||.::|:.:|.|..  ||:|
Human   264 RYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNP--RGFF 326

  Fly   363 LFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKN 427
            |||||||||||||::.|.||:.||..||.|:..|...||.:|||.:|::||||..|..||..|.:
Human   327 LFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGS 391

  Fly   428 DIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESE 492
            .|||:..|: |.|...|..|.|.|||||   .|::|.   |.::......:.::...|.|||:.|
Human   392 SIFGLAPGK-ARDRKAYTVLLYGNGPGY---VLKDGA---RPDVTESESGSPEYRQQSAVPLDGE 449

  Fly   493 THGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            ||.|:||||||.||.|.|..||.||.||.|.:.:|:||.....|
Human   450 THAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTAC 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	207/467 (44%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	202/451 (45%)
ALPG	NP_112603.2	PRK10518	25..475	CDD:236706	205/469 (44%)
		Alk_phosphatase	52..487	CDD:278666	203/452 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..443		2/23 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157475
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	1	0.950	-	0	Normalized mean entropy	S3647
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.760