DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phu and ALPP

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001623.3	Gene:	ALPP / 250	HGNCID:	439	Length:	535	Species:	Homo sapiens

Alignment Length:	501	Identity:	214/501 - (42%)
Similarity:	287/501 - (57%)	Gaps:	39/501 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG- 116
            |:....:..||...::|...||:.|.  ...||:.....|:|:::|:||||.:.|:||.|:..|
Human    18 QLSLGIIPVEEENPDFWNREAAEALG--AAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQ 80

  Fly   117 -----GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQA 176
                 |.|...|.::||||.|||||..:..|.||..||||||.|||.|:.|||:|||.:|..|
Human    81 KKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQC-- 143

  Fly   177 QAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPD 241
            .....:.|.|:...|:|.|.:.|:||||.|.||||||.|||..||||.:||:|.. :...:.|.|
Human   144 NTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPA-SARQEGCQD 207

  Fly   242 AAAQLINSPVGQKLNVIMGGGRENFLPKGVTD-------SSGAPGRRLDGRNLIDEW--KNQHTN 297
            .|.|||::   ..::||:||||:.....|..|       |.|  |.||||:||:.||  |.|
Human   208 IATQLISN---MDIDVILGGGRKYMFRMGTPDPEYPDDYSQG--GTRLDGKNLVQEWLAKRQ--- 264

  Fly   298 SAQYVENRRELL--NLSNHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRG 360
            .|:||.||.||:  :|....:.::|||.|..|.|.:.......|:|.||.::|:.:|.|..  ||
Human   265 GARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNP--RG 327

  Fly   361 YFLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSR 425
            :||||||||||||||::.|.||:.||..||.|:..|...||.:|||.:|::||||..|..||..|
Human   328 FFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLR 392

  Fly   426 KNDIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLE 490
            .:.|||:..|: |.|...|..|.|.|||||   .|::|.   |.::......:.::...|.|||:
Human   393 GSSIFGLAPGK-ARDRKAYTVLLYGNGPGY---VLKDGA---RPDVTESESGSPEYRQQSAVPLD 450

  Fly   491 SETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            .|||.|:||||||.||.|.|..||.||.||.|.:.:|:||.....|
Human   451 EETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTAC 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	206/469 (44%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	201/453 (44%)
ALPP	NP_001623.3	PRK10518	28..478	CDD:236706	204/471 (43%)
		Alk_phosphatase	55..490	CDD:278666	202/454 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..449		4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157488
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.810