DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phu and ALPI

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001622.2	Gene:	ALPI / 248	HGNCID:	437	Length:	528	Species:	Homo sapiens

Alignment Length:	497	Identity:	210/497 - (42%)
Similarity:	292/497 - (58%)	Gaps:	31/497 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG- 116
            |:....:.:||....:|...||:.||  ...||:...::|:|::||:|||:.:||:||.|:..|
Human    15 QLSLGVIPAEEENPAFWNRQAAEALD--AAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQ 77

  Fly   117 -----GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQA 176
                 |.|...|.::|||:.|||||..:.||.|||.||||||.|||||:.|||:|||.:|..|
Human    78 KNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQC-- 140

  Fly   177 QAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPD 241
            .....:.|.|:...|::.|.:.|:||||.|.||||||.|||..||||.:||::.. :...:.|.|
Human   141 NTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPA-SARQEGCQD 204

  Fly   242 AAAQLINSPVGQKLNVIMGGGRENFLPKGVTD-----SSGAPGRRLDGRNLIDEWKNQHTNSAQY 301
            .|.|||::   ..::||:||||:...|.|..|     .:...|.||||:||:.||..:| ..|.|
Human   205 IATQLISN---MDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKH-QGAWY 265

  Fly   302 VENRRELL--NLSNHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFLF 364
            |.||.||:  :|....:.::|||.|....|.:...|...|:|.||.::|:.:|.|..  ||::||
Human   266 VWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNP--RGFYLF 328

  Fly   365 VEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDI 429
            |||||||||||:.:|.:|:.|...||.|:..|...||.:|||.:|::||||..|..||:.|.:.|
Human   329 VEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSI 393

  Fly   430 FGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESETH 494
            ||:...: |.|...|.::.|.|||||..|    .|.  |.::......:.|:...:.|||.||||
Human   394 FGLAPSK-AQDSKAYTSILYGNGPGYVFN----SGV--RPDVNESESGSPDYQQQAAVPLSSETH 451

  Fly   495 GGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            ||:||||||.||.|.|..||.||.|:.|.:.:|:||.....|
Human   452 GGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTAC 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	202/465 (43%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	196/449 (44%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	197/450 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157462
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	1	0.950	-	0	Normalized mean entropy	S3647
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.760