DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and Alpi

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_073156.3	Gene:	Alpi / 24197	RGDID:	2099	Length:	540	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	209/499 - (41%)
Similarity:	285/499 - (57%)	Gaps:	41/499 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG---- 116
            |..:..||....:|...|.:.||  :..||:.....|:|::||:||||.:||:||.|:..|
  Rat    19 FGVIPVEEENPVFWNQKAKEALD--VAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGG 81

  Fly   117 --GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQ 179
              |.|...|.:.||:..|||||..:.||.|||.||||||.||||||.|||||||.:|..|  .:.
  Rat    82 HLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQC--NST 144

  Fly   180 AAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPDAAA 244
            ..:.|.|:...|:|.|.:.|:||||.|.||||||.|||..||:|.:||: :..:...:.|.|.|.
  Rat   145 FGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDAD-MPSSALQEGCKDIAT 208

  Fly   245 QLINSPVGQKLNVIMGGGRENFLPKGVTD-----SSGAPGRRLDGRNLIDEW--KNQHTNSAQYV 302
            |||::   ..::||:||||:...|||..|     .|...|.|||.|||::||  |.|.|   :||
  Rat   209 QLISN---MDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGT---RYV 267

  Fly   303 ENRRELLNLSNH--TSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFLFV 365
            .||.:|:..|..  .:|::|||.|..|.|.::.:.:..|:|.||.:.|:.:|.|..  :|::|||
  Rat   268 WNREQLMQASQDPAVTRLMGLFEPAEMKYDVNRNASADPSLAEMTEVAVRLLSRNP--QGFYLFV 330

  Fly   366 EGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIF 430
            ||||||.|||...|..|:.|...||.|:..|...|:..|||.::::||||..:..||:.|...||
  Rat   331 EGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIF 395

  Fly   431 G---INDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESE 492
            |   :|    |.|...|.::.|.|||||   .|..|   .|.|:......:.::...:.|||.||
  Rat   396 GLAPLN----AQDGKSYTSILYGNGPGY---VLNSG---NRPNVTDAESGDVNYKQQAAVPLSSE 450

  Fly   493 THGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            ||||:|||:||.||.|.|..||.||::|.|.:.:|.||.....|
  Rat   451 THGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDC 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	201/470 (43%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	196/454 (43%)
Alpi	NP_073156.3	Alk_phosphatase	53..488	CDD:278666	197/455 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351445
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.760