DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and AgaP_AGAP006400

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_316433.4	Gene:	AgaP_AGAP006400 / 1277011	VectorBaseID:	AGAP006400	Length:	525	Species:	Anopheles gambiae

Alignment Length:	499	Identity:	174/499 - (34%)
Similarity:	273/499 - (54%)	Gaps:	18/499 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GRYKRAMPQIVFDAVRS--------EERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGD 101
            |.::..:..::..||.|        ||..|.:|:.:|.:.|.::.:..:: ...:|:|:|:|:|.
Mosquito     5 GAWEALLSLLLILAVGSSWIQVKGHEEHDAHHWKHMAHELLYEKKDYTMQ-KINIAKNIMVFVGA 68

  Fly   102 GMSIPTITAGRVYLGGEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVS 166
            |||..|:|..|.|.||:.:.||||:..:.|.::|||.:.:|.||||..||:|.|||:|.||:.:.
Mosquito    69 GMSQTTVTGARYYNGGDNETFAFERLKWSGNARTYCVDSRVPDSACAGTAFLTGVKSNLGTVAMD 133

  Fly   167 AAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVG 231
            ..|:..:|  ....|..::|||.||.:.|.|.|..||:.||..|.|.:||:..:..|||||:|..
Mosquito   134 PTVRRGEC--AMDPAKQLASIAKWALEAGKAVGFATTSRVTSGSNAALYANSPDSRWENDADVGA 196

  Fly   232 DNGDPDLCPDAAAQLINSPVGQKLNVIMGGGRENFLPKGVTDSSGAPGRRLDGRNLIDEWKNQHT 296
            ...:....||.|.|||:..:|::..|::||||::|||...||.||..|.|.||:|||:|||....
Mosquito   197 GGCNTATVPDIAHQLIHGDIGKQFKVVLGGGRKHFLPTVETDPSGQRGLRTDGKNLINEWKQSKA 261

  Fly   297 N-SAQYVENRRELLNLSNHTSRV---LGLFAPYHMAYHLD-ASPAEQPTLEEMVQSAMEILERQS 356
            . :|.|:....||.:|.  ||::   .|||...|:.:..| .:.:..|.|..||..::|:|:::.
Mosquito   262 GANATYITTVNELASLD--TSKIDYLFGLFDYDHLPFSADIGNGSVTPALVRMVHYSLEMLQKKE 324

  Fly   357 AGRGYFLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAG 421
            ...|:.||||.|.|...|......:|.|:...:..|...|....:..:||.:..:|...|:||.|
Mosquito   325 HTNGFLLFVEDGNIRRAHGQNAPRKAFDQVRHYANAFNMAHMMANEQNTLFISMNDVGSTLSLPG 389

  Fly   422 YSSRKNDIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPST 486
            |.:|.:|:.....|..:||.|||..|:||.||.:.:.|....|.:....:........:...|:.
Mosquito   390 YPARSSDLLDTAAGISSADGLPYLGLTYATGPAHSTYYRTGSGRLDPMEVLQSVPNGLERTCPAL 454

  Fly   487 VPLESETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCL 530
            ||:.....||:|..|:||||:|.:.:|.:||||:.|.:.:|||:
Mosquito   455 VPMAEGADGGEDATVYASGPWAFMLSGGYEQHFVAHTIAFASCI 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	163/457 (36%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	162/441 (37%)
AgaP_AGAP006400	XP_316433.4	ALP_like	59..498	CDD:304875	163/442 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
TreeFam	1	0.960	-	-
	7	6.880