DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and AgaP_AGAP011302

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_309345.4	Gene:	AgaP_AGAP011302 / 1270630	VectorBaseID:	AGAP011302	Length:	531	Species:	Anopheles gambiae

Alignment Length:	544	Identity:	256/544 - (47%)
Similarity:	338/544 - (62%)	Gaps:	37/544 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLQLFFFLGL----SVLVSGGESSHDAERRMHPVFSLMGTGSNPIGGGRYKRAMPQIVFDAVRSE 62
            :::.:.||||    ||.|.|.:  :|:::|.||..    ...|..|..:.|.|          .:
Mosquito     4 KIKYYNFLGLDLIFSVAVVGFD--YDSDKRHHPRL----PDENKPGLPKSKNA----------EQ 52

  Fly    63 ERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLGGEEKQFAFEQF 127
            |:..|||:..|..|:::.|..|  .||.:|:||::|:||||||.|:...|||.|||||..:||:|
Mosquito    53 EQTIEYWRNQAKATVEKLLAKK--ENTNVAKNVIMFLGDGMSISTVAMARVYAGGEEKPLSFEEF 115

  Fly   128 PYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQ 192
            |:||:|||||.|.|||||||||||||.|||.||.||||:|.|..:||.|......|.|||..||.
Mosquito   116 PFVGMSKTYCVNYQVADSACTATAYLTGVKGNYETIGVNAHVPVRDCNAARNRTTHTSSIGQWAM 180

  Fly   193 KQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPDAAAQLINSPVGQKLNV 257
            ..|...|:||||.||||||:|:|||:|.|:||:|..|..|...|:...|.|.||:......:|.|
Mosquito   181 DAGKDAGIVTTTRVTHASPSGMYAHIAFRDWEDDYWVQMDGCSPNEVDDIAEQLVYGETAPRLRV 245

  Fly   258 IMGGGRENFLPKGVTD--SSGAPGRRLDGRNLIDEW-KNQHT-NSAQYVENRRELLNLSNH-TSR 317
            |:||||..|:.:.:..  .:|..|.|.|||:||:|| ||... .:..:|..|.:|:.:..| |.|
Mosquito   246 ILGGGRREFMDREIHQDYETGRGGYRSDGRHLINEWLKNGPVGQNRTFVWKRSDLMAVDPHRTDR 310

  Fly   318 VLGLFAPYHMAYHLD---ASPAEQPTLEEMVQSAMEILERQSAGRGYFLFVEGGRIDHGHHDTLA 379
            :||:|.|.|..|:||   .:..|:|||.|||..|.:||....  .|:|||||||||||||||..|
Mosquito   311 LLGMFEPSHCVYNLDRVHKNLDEEPTLSEMVDKATDILSTNP--EGFFLFVEGGRIDHGHHDNQA 373

  Fly   380 LRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFGINDGQLAADDLPY 444
            ..|||||.||.||:..||...|.:||||||:|||||::|.:||.||..||||  ......|.:||
Mosquito   374 RYAIDETVEFAKAIELARKKFSEEDTLIVVTSDHSHSVSFSGYPSRGQDIFG--PAGTGKDGIPY 436

  Fly   445 ATLSYANGPGYDSNYLREGGAVRRKNLRAI-NMKNKDFMFPSTVPLESETHGGDDVAVFASGPYA 508
            .|:|||||.|:..:.....|.  |.|:|.: :....||.||:.:|::.|||||:||||:||||:|
Mosquito   437 MTISYANGLGFYKHVDEAKGT--RANVREMEDAGADDFRFPAMLPVDLETHGGEDVAVYASGPWA 499

  Fly   509 QLFTGVFEQHFIPHALGYASCLSD 532
            .||||.:||:.|||.:.||:|:.:
Mosquito   500 HLFTGSYEQNVIPHMMAYAACIGN 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	233/461 (51%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	228/445 (51%)
AgaP_AGAP011302	XP_309345.4	alkPPc	81..522	CDD:214515	229/446 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	6	5.830