DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and AgaP_AGAP012634

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_307568.4	Gene:	AgaP_AGAP012634 / 1268988	VectorBaseID:	AGAP012634	Length:	564	Species:	Anopheles gambiae

Alignment Length:	512	Identity:	230/512 - (44%)
Similarity:	311/512 - (60%)	Gaps:	31/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GTGSNPIG--------GGRYKRAMPQIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQ-- 90
            |..:||:.        |..:....|..|.....::|:..|||.......|.:|||    ||.|
Mosquito    20 GVLANPLSNFVTVPNLGPTHPMDNPDWVPPTAPTKEKDREYWLTSGQARLRRQLE----LNEQNI 80

  Fly    91 -LARNVMLFIGDGMSIPTITAGRVYLGGEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLG 154
             :|:||::|:|||:||||:.|.|:|:||||.:.:||.||:.||:||||.|.||:||||||.|.|.
Mosquito    81 NVAKNVIIFLGDGLSIPTLAATRMYMGGEELELSFETFPHTGLAKTYCINYQVSDSACTAAAILT 145

  Fly   155 GVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLA 219
            |||.||||||||..|..::|....|.::.::||..:||:.|.:||:||.|.:|||:||..||...
Mosquito   146 GVKNNYGTIGVSGHVPLRNCPLSLQESNRLTSILKYAQEDGRSTGIVTNTRITHATPAVAYAVSG 210

  Fly   220 NRNWENDAEVVGDNGDPDLCPDAAAQLINSPVGQKLNVIMGGGRENFLPKGVTDSSGAPGRRLDG 284
            .|.||:|.|:      |..|.|.|.||::..:|..|.|.:|||..:|.|.|..|.:|.||||.||
Mosquito   211 ARYWEDDTEL------PPGCVDIATQLVHGDIGTNLTVALGGGSRHFYPTGTLDRNGEPGRRTDG 269

  Fly   285 RNLIDEWKNQ---HTNSAQYVENRRELLNLSNH-TSRVLGLFAPYHMAYHLDASPAEQPTLEEMV 345
            |||:|||.|.   ....||:|.:|..|:.:... ..|:.|||:..||:|.:.|....:|:|:||.
Mosquito   270 RNLVDEWINDAVARELRAQFVHDRTGLMAIQPELVDRLFGLFSGNHMSYRMLADAQREPSLQEMT 334

  Fly   346 QSAMEILERQSAGRGYFLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFA--RSHTSTDDTLIV 408
            ..|:|||.|..  |||.|.||||||||.|||.||..|:|||.|..:||..|  :...|..:||::
Mosquito   335 IKALEILRRND--RGYVLLVEGGRIDHAHHDNLAKLALDETVELHRAVESAVRQLDESVQETLVL 397

  Fly   409 VSSDHSHTMSLAGYSSRKNDIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRA 473
            |::|||||.::.||..|.|||....|.. ..|.:|:.||:|||||.|..::...||.....::|.
Mosquito   398 VTADHSHTFTIGGYPVRGNDILSTGDFS-RFDRMPFFTLAYANGPSYADHFYENGGRRNPDDMRD 461

  Fly   474 INMKNKDFMFPSTVPLESETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCL 530
             ...:.||.:|:.||.|.||||||||||||.||:|.:|:|::|||.|.|.|.:|:||
Mosquito   462 -RFHDPDFTYPAAVPYEDETHGGDDVAVFAKGPWAHIFSGLYEQHVIGHGLLFAACL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	216/461 (47%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	210/442 (48%)
AgaP_AGAP012634	XP_307568.4	alkPPc	84..518	CDD:214515	212/444 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	7	6.930