DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and Akp3

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	503	Identity:	209/503 - (41%)
Similarity:	282/503 - (56%)	Gaps:	44/503 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG- 116
            |:....:..||....:|...||:.||  ...||:.....|:|:::|:||||.:||:||.|:..|
Mouse    15 QLSLSVIPVEEENPAFWNKKAAEALD--AAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQ 77

  Fly   117 -----GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQA 176
                 |.|...|.::|||:.|||||..:.||.|||.||||||.|||.||.|||||||.:|..|
Mouse    78 LEGHLGPETPLAMDRFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQC-- 140

  Fly   177 QAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGD---NGDPDL 238
            .....:.|.|:...|:|.|.:.|:||||.|.||||:|.|.|..||||..||::...   .|
Mouse   141 NTTFGNEVFSVMYRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNWYGDADMPASALREG---- 201

  Fly   239 CPDAAAQLINSPVGQKLNVIMGGGRENFLPKGVTD-----SSGAPGRRLDGRNLIDEWKNQHTNS 298
            |.|.|.|||::   ..:|||:||||:...|.|..|     .:...|.|||||||:.||.::|..|
Mouse   202 CKDIATQLISN---MDINVILGGGRKYMFPAGTPDPEYPNDANETGTRLDGRNLVQEWLSKHQGS 263

  Fly   299 AQYVENRRELLNLSNHTS--RVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGY 361
             |||.||.:|:..:...|  .::|||.|....:.:...|...|:|::|.::|:::|.|..  :|:
Mouse   264 -QYVWNREQLIQKAQDPSVTYLMGLFEPVDTKFDIQRDPLMDPSLKDMTEAAVKVLSRNP--KGF 325

  Fly   362 FLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRK 426
            :|||||||||.|||...|..|:.|...||.|:..|...||..|||.:|::||||..|..||:.|.
Mouse   326 YLFVEGGRIDRGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTADHSHVFSFGGYTLRG 390

  Fly   427 NDIFG---INDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVP 488
            ..|||   :|    |.|..||.::.|.|||||       .|...|.|:.|.......:...:.||
Mouse   391 TSIFGLAPLN----ALDGKPYTSILYGNGPGY-------VGTGERPNVTAAESSGSSYRQQAAVP 444

  Fly   489 LESETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            ::||||||:|||:||.||.|.|..||.||::|.|.:.:|.||.....|
Mouse   445 VKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPYTDC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	201/471 (43%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	195/455 (43%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	196/456 (43%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847868
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	1	0.950	-	0	Normalized mean entropy	S3647
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.760