DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and Alpl

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001274101.1	Gene:	Alpl / 11647	MGIID:	87983	Length:	524	Species:	Mus musculus

Alignment Length:	509	Identity:	223/509 - (43%)
Similarity:	304/509 - (59%)	Gaps:	43/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG------G 117
            |..:||...||:..|.:||...|:.: :|||.:|:||::|:||||.:.|:||.|:..|      |
Mouse    19 VPEKERDPSYWRQQAQETLKNALKLQ-KLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTG 82

  Fly   118 EEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAH 182
            ||.:...::||:|.|||||..|.||.|||.||||||.|||||.||:|||||.:...|  .....:
Mouse    83 EETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRC--NTTQGN 145

  Fly   183 HVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDL----CPDAA 243
            .|:||..||:..|.:.|:||||.|.||:|:..|||.|:|:|.:|.|:     .|:.    |.|.|
Mouse   146 EVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEM-----PPEALSQGCKDIA 205

  Fly   244 AQLINSPVGQKLNVIMGGGRENFLPKGVTD-----SSGAPGRRLDGRNLIDEWKN---QHTNSAQ 300
            .||:::.  :.::|||||||:...||..||     ...|.|.||||.:||..||:   :|.:| .
Mouse   206 YQLMHNI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHS-H 267

  Fly   301 YVENRRELLNLSNHTSRV---LGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYF 362
            ||.||.|||.|.  .|||   ||||.|..|.|.|:.:....|:|.|||:.|:.||.:..  :|:|
Mouse   268 YVWNRTELLALD--PSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNL--KGFF 328

  Fly   363 LFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKN 427
            |.|||||||||||:..|.:|:.|..|.|:|:..|.:.||..|||.||::||||..:..||:.|.|
Mouse   329 LLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGN 393

  Fly   428 DIFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESE 492
            .|||:.......|..|:..:.|.|||||.   :.:|   .|:|:..::..:.::...|.|||..|
Mouse   394 SIFGLAPMVSDTDKKPFTAILYGNGPGYK---VVDG---ERENVSMVDYAHNNYQAQSAVPLRHE 452

  Fly   493 THGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCL-SDRNMCVDGGVARRP 545
            ||||:||||||.||.|.|..||.||::|||.:.||||: ::.:.|...|....|
Mouse   453 THGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWAGSGSAP 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	211/473 (45%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	206/457 (45%)
Alpl	NP_001274101.1	Alk_phosphatase	51..490	CDD:333956	207/458 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847881
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37314
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	LDO	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810