DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phu and Alpp

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	210/498 - (42%)
Similarity:	286/498 - (57%)	Gaps:	33/498 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG- 116
            |:....|..||....:|...||:.|  :...||:.....|.|:::.:||||.:.|:||.|:..|
  Rat    14 QMSLSLVPVEEENPAFWNRKAAEAL--EAAKKLQPIQTSANNLIILMGDGMGVSTVTATRILKGQ 76

  Fly   117 -----GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQA 176
                 |.|...|.::||::.|||||..:.||.|||.|.||:|.|||.|...||:|||.:|..|
  Rat    77 QQGHLGPETPLAMDRFPHMALSKTYNTDKQVPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQC-- 139

  Fly   177 QAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPD 241
            .....:.|.|:...|:|.|.:.|:||||||.||||||.|||..||||.:||. :......:.|.|
  Rat   140 NTTWGNEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRNWYSDAH-MSTAALQEGCKD 203

  Fly   242 AAAQLINSPVGQKLNVIMGGGRENFLPKGV------TDSSGAPGRRLDGRNLIDEWKNQHTNSAQ 300
            .|.|||::   ..::||:||||:...|||.      ||...| |.|||||||:.||..:| ..||
  Rat   204 IAMQLISN---TDIDVILGGGRKFMFPKGTPDQEYPTDPQQA-GTRLDGRNLVQEWLAKH-QGAQ 263

  Fly   301 YVENRRELL--NLSNHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFL 363
            ||.||.||:  :|:...:.::|||.|..|.|::|..|.:.|:|.||.:.|:.:|.|..  :|::|
  Rat   264 YVWNRTELIQASLNRSVTHLMGLFEPNDMKYNIDRDPTQDPSLAEMTEVAVHMLSRNP--KGFYL 326

  Fly   364 FVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKND 428
            ||||||||||||:.:|.||:.|...||.||..|...||..||:|:|::||||..|..||:.|:..
  Rat   327 FVEGGRIDHGHHEAIAYRALTEAVMFDSAVDKADKLTSEKDTMIIVTADHSHVFSFGGYTQREAS 391

  Fly   429 IFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESET 493
            |||:...: |.|...:.::.|.|||||..|    .|.  |.::......|..:...:.|||.|||
  Rat   392 IFGLAPFK-AGDGKSFTSILYGNGPGYKLN----NGI--RADVTEEESSNPTYQQQAAVPLSSET 449

  Fly   494 HGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            |.|:|||:||.||.|.|..||.||::|.|.:.:|.||.....|
  Rat   450 HSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	201/466 (43%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	196/450 (44%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	197/451 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351432
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.860