DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phu and alp3

DIOPT Version :9

Sequence 1:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001265768.1	Gene:	alp3 / 100330410	ZFINID:	ZDB-GENE-120919-1	Length:	534	Species:	Danio rerio

Alignment Length:	486	Identity:	200/486 - (41%)
Similarity:	291/486 - (59%)	Gaps:	34/486 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG------GEEK 120
            ||...|:|:..|..||...|..|  :||.:|:|::||:||||.:.||||.|:..|      |||.
Zfish    21 EEENPEFWRKSAQNTLRSALSRK--INTNVAKNIVLFLGDGMGVTTITAARILKGQLQKHSGEET 83

  Fly   121 QFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVS 185
            ....:.||.|||:|.|..:.|:.|||.||||||.|||.|..|:|||||.:...|  ::|..:.|:
Zfish    84 VMNMDTFPNVGLAKVYSVDFQIPDSAATATAYLCGVKTNLNTVGVSAAARNGVC--RSQKGNEVT 146

  Fly   186 SIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPDAAAQLINSP 250
            ||..||:..|.:.|:||||.|.||:||..:||.|:|.|.:||::.. :...:.|.|.|.||:::
Zfish   147 SILRWAKDAGKSVGIVTTTRVQHATPAASFAHSASRTWYSDADLPA-SAATEGCVDIATQLLHN- 209

  Fly   251 VGQKLNVIMGGGRENFLPKGVTD-----SSGAPGRRLDGRNLIDEW-KNQHTNSAQYVENRRELL 309
              ..::||:||||:...|||..|     .:.|.|:|.||||||.:| :.:....|:||.|:.:..
Zfish   210 --IDIDVIIGGGRKYMTPKGFPDPEYPSDASAQGQRRDGRNLIQDWIQMKEGKVARYVWNKTDFD 272

  Fly   310 NLS-NHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFLFVEGGRIDHG 373
            .:. ..|..::.||.|..:.:.::...:..|::.|....|::||::..  :|:||.|||||||.|
Zfish   273 AVDPEKTDYLMALFEPADLRFDVERDHSMDPSISETTDKAIQILKKNP--KGFFLLVEGGRIDQG 335

  Fly   374 HHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFGINDGQLA 438
            ||.:.|..|:.|....|:||......|..::||.:|::||||..:..||..|.|.|.| .....|
Zfish   336 HHSSRASAALHEAVALDEAVSRGLELTDEEETLTIVTADHSHAFTFNGYPFRGNSILG-KSPIFA 399

  Fly   439 ADDLPYATLSYANGPGY--DSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESETHGGDDVAV 501
            :|.|||.||.|.||||:  .:|        :|.::|.::..:||::..|.|||:||||||:||||
Zfish   400 SDFLPYTTLMYGNGPGHKITNN--------KRPDIRKVDTADKDYIQQSAVPLDSETHGGEDVAV 456

  Fly   502 FASGPYAQLFTGVFEQHFIPHALGYASCLSD 532
            ||.||.|.||.||:||::||||:.||:|:.:
Zfish   457 FARGPMAHLFQGVYEQNYIPHAMAYAACIGE 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phu	NP_649897.4	PhoA	71..524	CDD:224699	192/467 (41%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	187/451 (41%)
alp3	NP_001265768.1	PhoA	30..482	CDD:224699	193/470 (41%)
alp3	NP_001265768.1	Alk_phosphatase	49..485	CDD:278666	188/452 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593218
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37314
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910