Protein Alignment CG16779 and MIDEAS

DIOPT Version :10

• Sequence 1: NP_649896.2
• Gene: CG16779 / 41134
• FlyBaseID: FBgn0037698
• Length: 2005
• Species: Drosophila melanogaster
• Sequence 2: NP_001354639.1
• Gene: MIDEAS / 91748
• HGNCID: 19853
• Length: 1099
• Species: Homo sapiens
• Alignment Length: 1005
• Identity: 212/1005 - (21%)
• Similarity: 322/1005 - (32%)
• Gaps: 404/1005 - (40%)

  Fly  1319 LSSEQQGENIIDLYYLPGLGLQSQMMPNSEDPLLSSSPREFGQQRQQLPMQTTN-MQQPMEQTL- 1381
            |..|:.|...:|.|..|       |||....       .|.|  |.|.|:.:.: .::|..|:|
Human   165 LKREKAGGPQLDRYVRP-------MMPQKVQ-------LEVG--RPQAPLNSFHAAKKPPNQSLP 213

  Fly  1382 ----------QDNNNIYQQ-------------QEQQQEQHQQQQSQQEQP--------------P 1409
                      |.|..:::|             |:|||:|..|||.||:|.              |
Human   214 LQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPLFENFYSMP 278

  Fly  1410 QQEQQQ-----------------QHHQQLLMPQQP------------LNQTESLPAVGQQQGDF- 1444
            ||..||                 .||.....|..|            |..:...||:.|.|..|
Human   279 QQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFP 343

  Fly  1445 ----------MLP--LVGGHGFTQVTSQTQYIDNSQGGMGMQ-------PLNSLLQP-------- 1482
                      :||  .:.|.|       ||....:.|.:.:.       |..||.||
Human   344 RRSRRLSKEGILPPSALDGAG-------TQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFP 401

  Fly  1483 --------LLYGGATTSNG---NASAGGNE----SLLTTDCQMNANQGQIDTGLMFAC------- 1525
                    |..|.....||   .|.|.|:|    ::.|.||      ||:..|.:...
Human   402 LELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDC------GQVLRGGVIQSTRRRRRA 460

  Fly  1526 ---GNTTTMANKS--LAAIVS-------------------------NPPSVANLQ---------- 1550
               .|..|:|.|:  ||::.:                         :.||:|..:
Human   461 SQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPL 525

  Fly  1551 --------------------------------PLSNQTNSILKRRLRSNAP-------------- 1569
                                            |..::.:.|:.||..:..|
Human   526 IIPVSVPVRTVDPTEAAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVK 590

  Fly  1570 ---QETHKFSK----------------------FHTLSPHRSKLRKPSR--TH----------YT 1597
               :.:.:..|                      :..::|::|.||.|.|  .|          ||
Human   591 LEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPYQSHLRSPVRLADHPSERSFELPPYT 655

  Fly  1598 PAPILNPDRKGTGLYCN--------------VRKQLGQGLFDAFDDD--------FGDSVGLVDF 1640
            |.|||:|.|:|:|||.|              ..|...:.|......:        .|::..:
Human   656 PPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPV--- 717

  Fly  1641 SDESKVNLGSTYQAQIPSCRPLEEALRDSPGAEMMWNP-EVQEDEKILMRYID----LSKSSAVP 1700
            |.|.::|:||.:||:||..|....|..|...|:::|.| |..|..:...|.::    .:.||..|
Human   718 SIEPRINVGSRFQAEIPLMRDRALAAADPHKADLVWQPWEDLESSREKQRQVEDLLTAACSSIFP 782

  Fly  1701 MGSHSEEVALQTLLRAKGNSAAAVLSLLQTQ--------------SGAFQMKWTAYELEQFLRGL 1751
            ....::|:||..|..::|:....:..||..:              :|:.|  |...|.:.|.:|:
Human   783 GAGTNQELALHCLHESRGDILETLNKLLLKKPLRPHNHPLATYHYTGSDQ--WKMAERKLFNKGI 845

  Fly  1752 EKNGKDFGKIASELQTKSSGECVQMYYFWKK--------------------------LCVDYKVT 1790
            ....|||..:...:|||:..:||:.||.:||                          :.||.| |
Human   846 AIYKKDFFLVQKLIQTKTVAQCVEFYYTYKKQVKIGRNGTLTFGDVDTSDEKSAQEEVEVDIK-T 909

  Fly  1791 HLKMEPVVVIAPAVEKPYVCEIADCSASFSSKAALHGHVRIHAYGRSASSNTTNNNSSSSNTGSS 1855
            ..|...|.:  |..|.|             |:..|.....:....:...................
Human   910 SQKFPRVPL--PRRESP-------------SEERLEPKREVKEPRKEGEEEVPEIQEKEEQEEGR 959

  Fly  1856 SNVQHAAASSASSGGNNNNSSSYACATLSGSNGSSN-----NASTNVAGAVATHSSNMAQNGSNC 1915
            ...:.|||..|:.             ||..:..:|:     :..:|..|:....:|...:.|
Human   960 ERSRRAAAVKATQ-------------TLQANESASDILILRSHESNAPGSAGGQASEKPREG--- 1008

  Fly  1916 SGHANAAIATSALSTTPKLEAGMGNTTNIPIAKEGEFPCKVCGKVFNKVKSRSAHMKTHRVQEPD 1980
            :|.:..|:   ..|...|.......|.|    :|..||||.||:||.||||||||||:|..||..
Human  1009 TGKSRRAL---PFSEKKKKTETFSKTQN----QENTFPCKKCGRVFYKVKSRSAHMKSHAEQEKK 1066

  Fly  1981 ----------------QKHQ--LQNQAGAG 1992
                            ..||  |:.::|||
Human  1067 AAALRLKEKEAAAAAAAAHQQALREESGAG 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16779	NP_649896.2	C2H2 Zn finger	329..349	CDD:275368
		zf-C2H2	355..377	CDD:395048
		C2H2 Zn finger	357..377	CDD:275368
		C2H2 Zn finger	385..407	CDD:275368
		ELM2	1646..1696	CDD:460214	16/54 (30%)
		SANT	1738..1782	CDD:473887	14/43 (33%)
		C2H2 Zn finger	1810..1832	CDD:275368	2/21 (10%)
		zf-C2H2_6	1952..1975	CDD:433576	18/22 (82%)
		C2H2 Zn finger	1954..1974	CDD:275368	16/19 (84%)
MIDEAS	NP_001354639.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	99..159
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..264		12/35 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	276..305		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..349		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..397		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..441		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..563		1/19 (5%)
		ELM2	723..778	CDD:460214	16/54 (30%)
		SANT	832..876	CDD:473887	15/45 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	887..1045		34/196 (17%)