Protein Alignment CG16779 and TRERF1

DIOPT Version :10

• Sequence 1: NP_649896.2
• Gene: CG16779 / 41134
• FlyBaseID: FBgn0037698
• Length: 2005
• Species: Drosophila melanogaster
• Sequence 2: XP_016866535.1
• Gene: TRERF1 / 55809
• HGNCID: 18273
• Length: 1232
• Species: Homo sapiens
• Alignment Length: 1331
• Identity: 281/1331 - (21%)
• Similarity: 426/1331 - (32%)
• Gaps: 555/1331 - (41%)

  Fly  1068 LNDEEI-KSEHSEDFALLSEAGDSAHTQLVKLEPESGQANSGSGSVSGA-----NTTPL-PTFQQ 1125
            :.|::: |:.|      ::...::...|...|...||..::...:|:|.     ..:|: |.|.|
Human     1 MGDQQLYKTNH------VAHGSENLFYQQPPLGVHSGLNHNYGNAVTGGGMDAPQASPISPHFPQ 59

  Fly  1126 ---------FHSKELIMQNSSQIQAIASMRGSGGGVLASPLHSPLAYPTPPSSHENMAQSSPFIE 1181
                     ..||.|...::|:.....|..|.|..|   .|...||       :.||...:|
Human    60 DTRDGLGLPVGSKNLGQMDTSRQGGWGSHAGPGNHV---QLRGNLA-------NSNMMWGAP--- 111

  Fly  1182 DAAAQFVDASNTFFGDKTDF------SHIYFKTDEGEATIEQLNEHDNEKIL--KLKSVLEDSSF 1238
             |.|:..|.....:...::.      |.:..|.|    :..|:..:.|.:|.  .:..||...|
Human   112 -AQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLD----SFTQVFANQNLRIQVNNMAQVLHTQS- 170

  Fly  1239 DPSIKVEDLLNGTDDDTECDLREFAETNLSFLDEDQEFLNDSRNATSPLSESF------------ 1291
                   .:::|..|..   ||:..                |:....|.:.:.
Human   171 -------AVMDGAPDSA---LRQLL----------------SQKPMEPPAPAIPSRYQQVPQQPH 209

  Fly  1292 --FTSGIGSAE--------------DVKQVLREVLPDENMQLQ--------LSSEQQGENIIDLY 1332
              ||.|:....              |.:|.|.:|.......||        :...||.:     |
Human   210 PGFTGGLSKPALQVGQHPTQGHLYYDYQQPLAQVPVQGGQPLQAPQMLSQHMQQMQQHQ-----Y 269

  Fly  1333 YLPGLGLQS---------------QMMPNSEDPLLSSSPREFGQQRQQLPMQTT--NMQ------ 1374
            |.|....|:               |:.|:...|    .|::  ||.|||.:|..  :||
Human   270 YPPQQQQQAGQQRISMQEIQTQPQQIRPSQPQP----PPQQ--QQPQQLQLQQRQGSMQIPQYYQ 328

  Fly  1375 -QPMEQTLQDNNNIYQQQEQQQEQHQQQQSQQEQPPQQEQQQQHHQQLL-----------MPQQP 1427
             |||.|.|        |::|||:.|.|..|....|.|...:|.|..||:           .||||
Human   329 PQPMMQHL--------QEQQQQQMHLQPPSYHRDPHQYTPEQAHTVQLIPLGSMSQYYYQEPQQP 385

  Fly  1428 LNQ---TESLPAVGQQQGDFML----------PLVGGHG----------------FTQVTSQTQY 1463
            .:.   .:|..:..||:.|..|          .::..||                .|:|:|...:
Human   386 YSHPLYQQSHLSQHQQREDSQLKTYSSDRQAQAMLSSHGDLGPPDTGMGDPASSDLTRVSSTLPH 450

  Fly  1464 ID---------NSQGGMGMQPLNSLLQPLLYGGATTSNGNASAGGNESLLTTDCQMNANQGQIDT 1519
            ..         |:.|....|...|.:.|.::    ..:|.|..|..||         :.|.:...
Human   451 RPLLSPSGIHLNNMGPQHQQLSPSAMWPQMH----LPDGRAQPGSPES---------SGQPKGAF 502

  Fly  1520 GLMFACGNTTTMA-----NKSLAAIVSN------------------------------------- 1542
            |..|...|..|.:     .|:|.|:..:
Human   503 GEQFDAKNKLTCSICLKEFKNLPALNGHMRSHGGMRASPNLKQEEGEKVLPPQPQPPLPPPPPPP 567

  Fly  1543 -----PPSVANLQPL---------------SNQ--TNSI-------------------------- 1559
                 ||...:|.|:               |:|  |||.
Human   568 PPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFTNSTVAAPSARDKPASSMSDDEMPVLVRMT 632

  Fly  1560 -----------------LKRRLRSNAP---------QETHKFSKFHTLSP--------------- 1583
                             :.|:.:.:.|         ||..||.  |...|
Human   633 LSPPHSPQGAAPRTPAEIPRKHQPSVPKAEEPLKTVQEKKKFR--HRPEPLFIPPPPSYNPNPAA 695

  Fly  1584 -------HRSKLRKP---------SRTH----YTPAPILNPDRKGTGLYCNVRKQLGQG------ 1622
                   ::|:||.|         ..||    |||.|:|:|.|:|:||:.||... |.|
Human   696 SYSGATLYQSQLRSPRVLGDHLLLDPTHELPPYTPPPMLSPVRQGSGLFSNVLIS-GHGPGAHPQ 759

  Fly  1623 ------------LFDAFDDDFGDSVGL--------VDFSDESKVNLGSTYQAQIPSCRPLEEALR 1667
                        |....:...|.:|.:        ||.  |.::|:|..:||:||..:.:....:
Human   760 LPLTPLTPTPRVLLCRSNSIDGSNVTVTPGPGEQTVDV--EPRINIGLRFQAEIPELQDISALAQ 822

  Fly  1668 DSPGAEMMWNP----EVQEDEKILMRYIDLSKSSAVPMGSHSEEVALQTLLRAKGNSAAAVLSLL 1728
            |:..|.::|.|    |..:.::.:...::|..|||:|.|..:.|.||.:|..|||:...|:..||
Human   823 DTHKATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMVALEMLL 887

  Fly  1729 QTQSGAFQM------------KWTAYELEQFLRGLEKNGKDFGKIASELQTKSSGECVQMYYFWK 1781
            ..:....:.            |||:.|.:.|.:.|....|||..:...:::|:..:||:.||.||
Human   888 LRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWK 952

  Fly  1782 KL-----------------CV------------------DYKVTHLKME-----------PVVVI 1800
            |:                 ||                  |.|.|  |.|           ||.|:
Human   953 KIMRLGRKHRTRLAEIIDDCVTSEEEEELEEEEEEDPEEDRKST--KEEESEVPKSPEPPPVPVL 1015

  Fly  1801 APAVEKP----------YVCEIADCSAS------------FSSKAALHGHVRIHAYGRSASSNTT 1843
            ||....|          ::||:.:|.|.            |||:.||:||.|||
Human  1016 APTEGPPLQALGQPSGSFICEMPNCGADCRCHVTPFLPQVFSSRQALNGHARIH----------- 1069

  Fly  1844 NNNSSSSNTGSSSNVQHAAASSASSGGNNNNSSSYACATLSGSNGSSNNASTNVAGAVATHSSNM 1908
                                     ||.|.                    .|...||:   .|..
Human  1070 -------------------------GGTNQ--------------------VTKARGAI---PSGK 1086

  Fly  1909 AQNGSNCSGHANAAIATSALSTTPKLEAGMGNTTNIPIAKEGEFPCKVCGKVFNKVKSRSAHMKT 1973
            .:.|...||:.:...:.|. |||    :|..:.|.|       ||||.|||||.|:|||:|||||
Human  1087 QKPGGTQSGYCSVKSSPSH-STT----SGETDPTTI-------FPCKECGKVFFKIKSRNAHMKT 1139

  Fly  1974 HRVQEPDQKHQLQNQAGAGLTTVATSTITAP 2004
            ||.||..|:.:.|..|.|..........|.|
Human  1140 HRQQEEQQRQKAQKAAFAAEMAATIERTTGP 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16779	NP_649896.2	C2H2 Zn finger	329..349	CDD:275368
		zf-C2H2	355..377	CDD:395048
		C2H2 Zn finger	357..377	CDD:275368
		C2H2 Zn finger	385..407	CDD:275368
		ELM2	1646..1696	CDD:460214	12/53 (23%)
		SANT	1738..1782	CDD:473887	15/43 (35%)
		C2H2 Zn finger	1810..1832	CDD:275368	12/33 (36%)
		zf-C2H2_6	1952..1975	CDD:433576	18/22 (82%)
		C2H2 Zn finger	1954..1974	CDD:275368	15/19 (79%)
TRERF1	XP_016866535.1	zf-C2H2_6	514..534	CDD:433576	3/19 (16%)
		ELM2	801..855	CDD:460214	12/53 (23%)
		SANT	909..953	CDD:473887	15/43 (35%)
		zf-C2H2_6	1117..1140	CDD:433576	18/29 (62%)
		C2H2 Zn finger	1118..1140	CDD:275369	17/21 (81%)